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We performed a systematic review and meta-analysis of the current literature to evaluate the state-of-the-art and investigate the epidemiology and clinical features of pseudocirrhosis. We searched PubMed, Web of Science and Scopus for literature published until February 28, 2022. We included in the final analysis 62 articles (N\u2009=\u2009389 patients): 51 case reports (N\u2009=\u200964 patients), 5 case series (N\u2009=\u200935 patients) and 6 observational studies (N\u2009=\u2009290 patients). About 80% of patients included in the case reports and case series had breast cancer. Most patients had at least one clinical sign of portal hypertension and ascites was the most common clinical manifestation of portal hypertension. The median time from pseudocirrhosis to death was 2\u00a0months (IQR 1\u20137\u00a0months). Alkylating agents and antimitotics were the most common classes of anticancer drugs reported in our study population. Notably, about 70% of patients received three or more anticancer drugs. Finally, pseudocirrhosis is a condition that occurs in patients with hepatic metastases and may have a negative impact on survival and clinical management of patients because of the potential development of portal hypertension and its complications.<\/jats:p>","DOI":"10.1038\/s41598-022-24241-2","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T16:02:57Z","timestamp":1668787377000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Pseudocirrhosis and portal hypertension in patients with metastatic cancers: a systematic review and meta-analysis"],"prefix":"10.1038","volume":"12","author":[{"given":"Rosanna","family":"Villani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Di Cosimo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moris","family":"Sangineto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino Davide","family":"Romano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Serviddio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,18]]},"reference":[{"key":"24241_CR1","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1007\/s10549-019-05311-y","volume":"177","author":"C Oliai","year":"2019","unstructured":"Oliai, C. et al. 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