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This study focused on the tolerance response by <jats:italic>A. bisporus<\/jats:italic> to different contents of Cd in the closed cup and the flat stage of fruiting body development. The contents of Cd, soluble protein, sugar, low molecular weight organic acids (LMWOAs), and antioxidant activity were investigated. The bioaccumulation factor and transfer factor results revealed that Cd accumulated in the cap of <jats:italic>A. bisporus<\/jats:italic> more than that in the stipe with the highest content being 18.38\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup> dry weight at the closed cup stage under 414.28\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup> Cd stress. High Cd content stress increased soluble protein, proline, and malonaldehyde contents at both stages; while higher peroxidase, catalase, ascorbic acid peroxidase activities, and LMWOAs contents were only recorded at the closed cup stage. On the other hand, Superoxide dismutase activities and soluble sugar content showed a complex trend. Overall, these results have successfully established that <jats:italic>A. bisporus<\/jats:italic> could resort to modulating its metabolism to avoid the destructive effects of Cd stress and could successfully accumulate Cd in the soil, which is a promising prospect for the remediation of Cd-contaminated soils.<\/jats:p>","DOI":"10.1038\/s41598-022-24561-3","type":"journal-article","created":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T08:04:11Z","timestamp":1669190651000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Bioaccumulation and physiological changes in the fruiting body of Agaricus bisporus (Large) sing in response to cadmium"],"prefix":"10.1038","volume":"12","author":[{"given":"Haiyan","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianing","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,22]]},"reference":[{"key":"24561_CR1","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1007\/s10534-013-9659-6","volume":"26","author":"N Verbruggen","year":"2013","unstructured":"Verbruggen, N., Juraniec, M., Baliardini, C. & Meyer, C. 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