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This 14-week prospective study compared 6 adult male Yucatan test pigs with baseline mean age 1.5\u00a0years to 2 control pigs. The test pigs received a fully endoscopic NOTES-based duodenal-jejunal bypass including measurement of the bypassed limb and creation of a gastrojejunal anastomosis (GJA) using a gastrojejunal lumen-apposing metal stent (GJ-LAMS) at Week 0, placement of a duodenal exclusion device (DED) at Week 2, and endoscopic examinations at Weeks 6 and 10. At Week 14, the pigs were sacrificed for necropsy. All endoscopic procedures were technically successful. By Week 14, the controls had gained a mean 1.1\u2009\u00b1\u20092.1\u00a0kg (+\u20091.6%) while the intervention animals lost a mean 6.8\u2009\u00b1\u20093.9\u00a0kg (\u2212\u200910.5%) since baseline. GJ-LAMS migrations occurred in 3 pigs, two of which also had DED migration and\/or partial dislocation. Two other pigs died, one with aberrant splenic vein positioning near the GJA and the other from an unknown cause. An endoscopic bariatric bypass procedure with controlled bypass length was technically successful in all the cases and led to weight loss in test animals. Safety concerns must be further addressed.<\/jats:p>","DOI":"10.1038\/s41598-022-24614-7","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T12:04:22Z","timestamp":1669377862000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Feasibility of a new bariatric fully endoscopic duodenal-jejunal bypass: a pilot study in adult obese pigs"],"prefix":"10.1038","volume":"12","author":[{"given":"Jean-Michel","family":"Gonzalez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohaib","family":"Ouazzani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephane","family":"Berdah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Cauche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Delattre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce A.","family":"Peetermans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agostina","family":"Santoro-Schulte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ornela","family":"Gjata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Barthet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,24]]},"reference":[{"key":"24614_CR1","doi-asserted-by":"publisher","DOI":"10.4293\/JSLS.2021.00066","author":"BK Ibrahim Mohamed","year":"2022","unstructured":"Ibrahim Mohamed, B. 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Nicolas Cauche and Cecilia Delattre are full-time employees of Brussels Medical Device Center, which received a cooperative engineering grant from Boston Scientific Corporation. Joyce A. Peetermans, Agostina Santoro-Schulte and Ornela Gjata are full-time employees of Boston Scientific Corporation. Sohaib Ouazzani and Stephane Berdah have no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"20275"}}