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We used the\u00a0Surveillance, Epidemiology and End Results database to extract\u00a05432 DCIS-MI patients. Participants were divided into the BCS\u2009+\u2009RT group and the mastectomy group. We compared the overall survival (OS) and breast cancer-specific survival (BCSS) of the two groups using the Kaplan\u2013Meier method and Cox regressions before and after propensity score matching (PSM). Before PSM, both univariate and multivariate analyses showed that BCS\u2009+\u2009RT group had significantly higher OS and BCSS compared with patients in the mastectomy group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). After PSM, the multivariate analysis showed that compared with mastectomy, the BCS\u2009+\u2009RT showed significantly higher OS and BCSS (HR\u2009=\u20090.676, 95% CI\u2009=\u20090.540\u20130.847, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001; HR\u2009=\u20090.565,95% CI\u2009=\u20090.354\u20130.903, <jats:italic>P<\/jats:italic>\u2009=\u20090.017). In addition, the subgroup analysis showed that BCS\u2009+\u2009RT is at least equivalent to mastectomy with respect to OS and BCSS in any subgroup. For patients with DCIS-MI, the prognosis of BCS\u2009+\u2009RT was superior to mastectomy.<\/jats:p>","DOI":"10.1038\/s41598-022-24630-7","type":"journal-article","created":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T10:17:34Z","timestamp":1669198654000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Survival outcomes after breast-conserving surgery plus radiotherapy compared with mastectomy in breast ductal carcinoma in situ with microinvasion"],"prefix":"10.1038","volume":"12","author":[{"given":"Lin-Yu","family":"Xia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Yun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing-Lin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,11,22]]},"reference":[{"key":"24630_CR1","doi-asserted-by":"publisher","first-page":"3628","DOI":"10.1200\/JCO.2002.02.026","volume":"20","author":"SE Singletary","year":"2002","unstructured":"Singletary, S. 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