{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:31:06Z","timestamp":1792791066347,"version":"4.5.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T00:00:00Z","timestamp":1669075200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T00:00:00Z","timestamp":1669075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"\u00c5kershus University Hospital research funding","id":[{"id":"https:\/\/ror.org\/0331wat71","id-type":"ROR","asserted-by":"crossref"}]},{"name":"State reseach funding"},{"name":"Finnish intensice care society grant"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Subarachnoid hemorrhage (SAH) is a serious condition, and a myocardial injury or dysfunction could contribute to the outcome. We assessed the prevalence and prognostic impact of cardiac involvement in a cohort with SAH. This is a prospective observational multicenter study. We included 192 patients treated for non-traumatic subarachnoid hemorrhage. We performed ECG recordings, echocardiographic examinations, and blood sampling within 24\u00a0h of admission and on days 3 and 7 and at 90\u00a0days. The primary endpoint was the evidence of cardiac involvement at 90\u00a0days, and the secondary endpoint was to examine the prevalence of a myocardial injury or dysfunction. The median age was 54.5 (interquartile range [IQR] 48.0\u201364.0) years, 44.3% were male and the median World Federation of Neurological Surgeons (WFNS) score was 2 (IQR 1\u20134). At day 90, 22\/125 patients (17.6%) had left ventricular ejection fractions\u2009\u2264\u200950%, and 2\/121 patients (1.7%) had evidence of a diastolic dysfunction as defined by mitral peak E-wave velocity by peak e\u02b9 velocity (E\/e\u02b9)\u2009&gt;\u200914. There was no prognostic impact from echocardiographic evidence of cardiac complications on neurological outcomes. The overall prevalence of cardiac dysfunction was modest. We found no demographic or SAH-related factors associated with 90\u00a0days cardiac dysfunction.<\/jats:p>","DOI":"10.1038\/s41598-022-24675-8","type":"journal-article","created":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T05:17:34Z","timestamp":1669180654000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The prevalence of cardiac complications and their impact on outcomes in patients with non-traumatic subarachnoid hemorrhage"],"prefix":"10.1038","volume":"12","author":[{"given":"Maarit","family":"L\u00e5ng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan M.","family":"Jakob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riikka","family":"Takala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus N.","family":"Lyngbakken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anu","family":"Turpeinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torbj\u00f8rn","family":"Omland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias M.","family":"Merz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Wiegand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha","family":"Gr\u00f6nlund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Rahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Valtonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Koivisto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helge","family":"R\u00f8sj\u00f8","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stepani","family":"Bendel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,22]]},"reference":[{"key":"24675_CR1","volume":"2014","author":"S Chen","year":"2014","unstructured":"Chen, S. et al. The harmful effects of subarachnoid hemorrhage on extracerebral organs. Biomed. Res. Int. 2014, 858496 (2014).","journal-title":"Biomed. Res. Int."},{"key":"24675_CR2","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1385\/NCC:5:3:243","volume":"5","author":"VH Lee","year":"2006","unstructured":"Lee, V. H., Oh, J. K., Mulvagh, S. L. & Wijdicks, E. F. Mechanisms in neurogenic stress cardiomyopathy after aneurysmal subarachnoid hemorrhage. Neurocrit. Care. 5, 243\u2013249 (2006).","journal-title":"Neurocrit. Care."},{"key":"24675_CR3","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1161\/01.STR.30.4.780","volume":"30","author":"SA Mayer","year":"1999","unstructured":"Mayer, S. A. et al. Myocardial injury and left ventricular performance after subarachnoid hemorrhage. Stroke 30, 780\u2013786 (1999).","journal-title":"Stroke"},{"key":"24675_CR4","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1161\/01.STR.0000114874.96688.54","volume":"35","author":"P Tung","year":"2004","unstructured":"Tung, P. et al. Predictors of neurocardiogenic injury after subarachnoid hemorrhage. Stroke 35, 548\u2013551 (2004).","journal-title":"Stroke"},{"key":"24675_CR5","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1053\/pcad.2002.124633","volume":"45","author":"YL Sakr","year":"2002","unstructured":"Sakr, Y. L., Ghosn, I. & Vincent, J. L. Cardiac manifestations after subarachnoid hemorrhage: A systematic review of the literature. Prog. Cardiovasc. Dis. 45, 67\u201380 (2002).","journal-title":"Prog. Cardiovasc. Dis."},{"key":"24675_CR6","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1016\/S0735-1097(00)00857-3","volume":"36","author":"N Parekh","year":"2000","unstructured":"Parekh, N. et al. Cardiac troponin I predicts myocardial dysfunction in aneurysmal subarachnoid hemorrhage. J. Am. Coll. Cardiol. 36, 1328\u20131335 (2000).","journal-title":"J. Am. Coll. Cardiol."},{"key":"24675_CR7","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1136\/jnnp.2004.060913","volume":"76","author":"WJ Schuiling","year":"2005","unstructured":"Schuiling, W. J. et al. Troponin I in predicting cardiac or pulmonary complications and outcome in subarachnoid haemorrhage. J. Neurol. Neurosurg. Psychiatry. 76, 1565\u20131569 (2005).","journal-title":"J. Neurol. Neurosurg. Psychiatry."},{"key":"24675_CR8","first-page":"1","volume":"16","author":"I Aisiku","year":"2014","unstructured":"Aisiku, I., Edlow, J. A., Goldstein, J. & Thomas, L. E. An evidence-based approach to diagnosis and management of subarachnoid hemorrhage in the emergency department. Emerg. Med. Pract. 16, 1\u201329 (2014).","journal-title":"Emerg. Med. 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