{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T12:53:26Z","timestamp":1793105606567,"version":"4.5.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T00:00:00Z","timestamp":1669161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T00:00:00Z","timestamp":1669161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"This study was supported by the Social Development Foundation of Shaanxi Province","award":["2017ZDXM-SF-009"],"award-info":[{"award-number":["2017ZDXM-SF-009"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>While there are multiple reports on venous thromboembolism (VTE) associated with several orthopedic procedures, the knowledge regarding incidence and risk factors of VTE in tibial plateau fractures is limited. This study aimed to investigate the incidence and risk factors of clinically important venous thromboembolism (CIVTE) in patients with tibial plateau fractures. All adult patients who underwent surgical treatment of tibia plateau fractures between 2003 and 2018 in our level 1 trauma center were included in the study. All patients suspected CIVTE were assessed by the ultrasonography and\/or CT scan. Univariate and multivariate analysis were used to evaluate the association between potential risk factors and CIVTE Variables. Thirty-nine of 462 patients (8.4%) developed clinically important venous thromboembolism, in which pulmonary embolism (PE) and deep vein thrombosis (DVT) were observed in 18 (3.9%) and 21 (4.54%) patients, respectively. Male gender (OR 9.75; 95% CI 2.34\u201340.66), spine injury (OR 9.51; 95% CI 3.39\u201326.64), other extremity injury (OR 3.7; 95% CI 1.58\u20138.66), length of stay in ICU (OR 1.14; 95% CI 1.09\u20131.2) were all risk factors for CIVTE. The incidence of CIVTE in tibial plateau fracture was relatively high (8.4%); The male gender, spine injury, other extremity injury, length of stay in ICU were the independent risk factors.<\/jats:p>","DOI":"10.1038\/s41598-022-24717-1","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T15:20:50Z","timestamp":1669303250000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Incidence and risk factors of clinically important venous thromboembolism in tibial plateau fractures"],"prefix":"10.1038","volume":"12","author":[{"given":"Pengfei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Fei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binfei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Utku","family":"Kandemir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,23]]},"reference":[{"key":"24717_CR1","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1056\/NEJM199412153312401","volume":"331","author":"WH Geerts","year":"1994","unstructured":"Geerts, W. H., Code, K. I., Jay, R. M., Chen, E. & Szalai, J. P. A prospective study of venous thromboembolism after major trauma. N. Engl. J. Med. 331, 1601\u20131606. https:\/\/doi.org\/10.1056\/NEJM199412153312401 (1994).","journal-title":"N. Engl. J. Med."},{"key":"24717_CR2","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1097\/00005131-199605000-00002","volume":"10","author":"G Abelseth","year":"1996","unstructured":"Abelseth, G., Buckley, R. E., Pineo, G. E., Hull, R. & Rose, M. S. Incidence of deep-vein thrombosis in patients with fractures of the lower extremity distal to the hip. J. Orthop. Trauma 10, 230\u2013235 (1996).","journal-title":"J. Orthop. Trauma"},{"key":"24717_CR3","doi-asserted-by":"publisher","first-page":"338S","DOI":"10.1378\/chest.126.3_suppl.338S","volume":"126","author":"WH Geerts","year":"2004","unstructured":"Geerts, W. H. et al. Prevention of venous thromboembolism: The seventh ACCP conference on antithrombotic and thrombolytic therapy. Chest 126, 338S-400S. https:\/\/doi.org\/10.1378\/chest.126.3_suppl.338S (2004).","journal-title":"Chest"},{"key":"24717_CR4","doi-asserted-by":"publisher","first-page":"132S","DOI":"10.1378\/chest.119.1_suppl.132S","volume":"119","author":"WH Geerts","year":"2001","unstructured":"Geerts, W. H. et al. Prevention of venous thromboembolism. Chest 119, 132S-175S (2001).","journal-title":"Chest"},{"key":"24717_CR5","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1097\/BOT.0000000000000873","volume":"31","author":"JT Patterson","year":"2017","unstructured":"Patterson, J. T. & Morshed, S. Chemoprophylaxis for venous thromboembolism in operative treatment of fractures of the tibia and distal bones: A systematic review and meta-analysis. J. Orthop. Trauma 31, 453\u2013460. https:\/\/doi.org\/10.1097\/BOT.0000000000000873 (2017).","journal-title":"J. Orthop. Trauma"},{"key":"24717_CR6","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1053\/j.jfas.2017.10.036","volume":"57","author":"JA Blanco","year":"2018","unstructured":"Blanco, J. A., Slater, G. & Mangwani, J. A prospective cohort study of symptomatic venous thromboembolic events in foot and ankle trauma: The need for stratification in thromboprophylaxis?. J. Foot Ankle Surg. 57, 484\u2013488. https:\/\/doi.org\/10.1053\/j.jfas.2017.10.036 (2018).","journal-title":"J. Foot Ankle Surg."},{"key":"24717_CR7","doi-asserted-by":"publisher","DOI":"10.1177\/1938640018769740","author":"SR Huntley","year":"2018","unstructured":"Huntley, S. R. et al. Incidence of and risk factors for venous thromboembolism after foot and ankle surgery. Foot Ankle Spec. https:\/\/doi.org\/10.1177\/1938640018769740 (2018).","journal-title":"Foot Ankle Spec."},{"key":"24717_CR8","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.fas.2015.02.002","volume":"21","author":"S Haque","year":"2015","unstructured":"Haque, S. & Davies, M. B. Oral thromboprophylaxis in patients with ankle fractures immobilized in a below the knee cast. Foot Ankle Surg. 21, 266\u2013268. https:\/\/doi.org\/10.1016\/j.fas.2015.02.002 (2015).","journal-title":"Foot Ankle Surg."},{"key":"24717_CR9","doi-asserted-by":"publisher","first-page":"e278S","DOI":"10.1378\/chest.11-2404","volume":"141","author":"Y Falck-Ytter","year":"2012","unstructured":"Falck-Ytter, Y. et al. Prevention of VTE in orthopedic surgery patients: Antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines. chest 141, e278S-e325S. https:\/\/doi.org\/10.1378\/chest.11-2404 (2012).","journal-title":"chest"},{"key":"24717_CR10","doi-asserted-by":"publisher","first-page":"e355","DOI":"10.1097\/BOT.0000000000000387","volume":"29","author":"HC Sagi","year":"2015","unstructured":"Sagi, H. C. et al. Venous thromboembolism prophylaxis in orthopaedic trauma patients: A survey of OTA member practice patterns and OTA expert panel recommendations. J. Orthop. Trauma 29, e355-362. https:\/\/doi.org\/10.1097\/BOT.0000000000000387 (2015).","journal-title":"J. Orthop. Trauma"},{"key":"24717_CR11","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.3928\/0147-7447-20041201-18","volume":"27","author":"NA Ebraheim","year":"2004","unstructured":"Ebraheim, N. A., Sabry, F. F. & Haman, S. P. Open reduction and internal fixation of 117 tibial plateau fractures. Orthopedics 27, 1281\u20131287 (2004).","journal-title":"Orthopedics"},{"key":"24717_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2018.05.018","author":"H Wang","year":"2018","unstructured":"Wang, H. et al. Perioperative incidence and locations of deep vein thrombosis following specific isolated lower extremity fractures. Injury https:\/\/doi.org\/10.1016\/j.injury.2018.05.018 (2018).","journal-title":"Injury"},{"key":"24717_CR13","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1007\/s00264-009-0790-5","volume":"34","author":"N Manidakis","year":"2010","unstructured":"Manidakis, N. et al. Tibial plateau fractures: Functional outcome and incidence of osteoarthritis in 125 cases. Int. Orthop. 34, 565\u2013570. https:\/\/doi.org\/10.1007\/s00264-009-0790-5 (2010).","journal-title":"Int. Orthop."},{"key":"24717_CR14","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1097\/BOT.0000000000000250","volume":"29","author":"R Selby","year":"2015","unstructured":"Selby, R. et al. A double-blind, randomized controlled trial of the prevention of clinically important venous thromboembolism after isolated lower leg fractures. J. Orthop. Trauma 29, 224\u2013230. https:\/\/doi.org\/10.1097\/BOT.0000000000000250 (2015).","journal-title":"J. Orthop. Trauma"},{"key":"24717_CR15","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1097\/00005131-199412000-00001","volume":"8","author":"DT Stamer","year":"1994","unstructured":"Stamer, D. T. et al. Bicondylar tibial plateau fractures treated with a hybrid ring external fixator: A preliminary study. J. Orthop. Trauma 8, 455\u2013461 (1994).","journal-title":"J. Orthop. Trauma"},{"key":"24717_CR16","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.2106\/JBJS.E.00907","volume":"88","author":"DP Barei","year":"2006","unstructured":"Barei, D. P. et al. Functional outcomes of severe bicondylar tibial plateau fractures treated with dual incisions and medial and lateral plates. J. Bone Joint Surg. 88, 1713\u20131721. https:\/\/doi.org\/10.2106\/JBJS.E.00907 (2006).","journal-title":"J. Bone Joint Surg."},{"key":"24717_CR17","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1097\/TA.0b013e318183801e","volume":"66","author":"SA Sems","year":"2009","unstructured":"Sems, S. A., Levy, B. A., Dajani, K., Herrera, D. A. & Templeman, D. C. Incidence of deep venous thrombosis after temporary joint spanning external fixation for complex lower extremity injuries. J. Trauma 66, 1164\u20131166. https:\/\/doi.org\/10.1097\/TA.0b013e318183801e (2009).","journal-title":"J. Trauma"},{"key":"24717_CR18","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1186\/1471-2474-14-177","volume":"14","author":"LJ Lapidus","year":"2013","unstructured":"Lapidus, L. J., Ponzer, S., Pettersson, H. & de Bri, E. Symptomatic venous thromboembolism and mortality in orthopaedic surgery: An observational study of 45 968 consecutive procedures. BMC Musculoskelet. Disord. 14, 177. https:\/\/doi.org\/10.1186\/1471-2474-14-177 (2013).","journal-title":"BMC Musculoskelet. Disord."},{"key":"24717_CR19","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/0002-9610(89)90182-7","volume":"158","author":"KA Kudsk","year":"1989","unstructured":"Kudsk, K. A. et al. Silent deep vein thrombosis in immobilized multiple trauma patients. Am. J. Surg. 158, 515\u2013519 (1989).","journal-title":"Am. J. Surg."},{"key":"24717_CR20","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1001\/archinte.158.6.585","volume":"158","author":"MD Silverstein","year":"1998","unstructured":"Silverstein, M. D. et al. Trends in the incidence of deep vein thrombosis and pulmonary embolism: A 25-year population-based study. Arch. Intern. Med. 158, 585\u2013593 (1998).","journal-title":"Arch. Intern. Med."},{"key":"24717_CR21","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1186\/s13054-015-1003-9","volume":"19","author":"C Minet","year":"2015","unstructured":"Minet, C. et al. Venous thromboembolism in the ICU: main characteristics, diagnosis and thromboprophylaxis. Crit. Care 19, 287. https:\/\/doi.org\/10.1186\/s13054-015-1003-9 (2015).","journal-title":"Crit. Care"},{"key":"24717_CR22","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1097\/TA.0b013e3182a9d11d","volume":"76","author":"RM Van Haren","year":"2014","unstructured":"Van Haren, R. M. et al. Hypercoagulability and other risk factors in trauma intensive care unit patients with venous thromboembolism. J. Trauma Acute Care Surg. 76, 443\u2013449. https:\/\/doi.org\/10.1097\/TA.0b013e3182a9d11d (2014).","journal-title":"J. Trauma Acute Care Surg."},{"key":"24717_CR23","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.injury.2011.10.006","volume":"44","author":"D Malinoski","year":"2013","unstructured":"Malinoski, D. et al. Risk factors for venous thromboembolism in critically ill trauma patients who cannot receive chemical prophylaxis. Injury 44, 80\u201385. https:\/\/doi.org\/10.1016\/j.injury.2011.10.006 (2013).","journal-title":"Injury"},{"key":"24717_CR24","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1016\/j.injury.2018.04.026","volume":"49","author":"JS Park","year":"2018","unstructured":"Park, J. S., Jang, J. H., Park, K. Y. & Moon, N. H. High energy injury is a risk factor for preoperative venous thromboembolism in the patients with hip fractures: A prospective observational study. Injury 49, 1155\u20131161. https:\/\/doi.org\/10.1016\/j.injury.2018.04.026 (2018).","journal-title":"Injury"},{"key":"24717_CR25","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s11239-015-1311-6","volume":"41","author":"JA Heit","year":"2016","unstructured":"Heit, J. A., Spencer, F. A. & White, R. H. The epidemiology of venous thromboembolism. J. Thromb. Thrombolysis 41, 3\u201314. https:\/\/doi.org\/10.1007\/s11239-015-1311-6 (2016).","journal-title":"J. Thromb. Thrombolysis"},{"key":"24717_CR26","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1097\/BRS.0000000000000754","volume":"40","author":"DY Kim","year":"2015","unstructured":"Kim, D. Y., Kobayashi, L., Chang, D., Fortlage, D. & Coimbra, R. Early pharmacological venous thromboembolism prophylaxis is safe after operative fixation of traumatic spine fractures. Spine 40, 299\u2013304. https:\/\/doi.org\/10.1097\/BRS.0000000000000754 (2015).","journal-title":"Spine"},{"key":"24717_CR27","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1097\/TA.0000000000001916","volume":"85","author":"M Zeeshan","year":"2018","unstructured":"Zeeshan, M. et al. Optimal timing of initiation of thromboprophylaxis in spine trauma managed operatively: A nationwide propensity-matched analysis of trauma quality improvement program. J. Trauma Acute Care Surg. 85, 387\u2013392. https:\/\/doi.org\/10.1097\/TA.0000000000001916 (2018).","journal-title":"J. Trauma Acute Care Surg."},{"key":"24717_CR28","doi-asserted-by":"publisher","first-page":"E21","DOI":"10.3171\/2017.8.FOCUS17437","volume":"43","author":"AM DiGiorgio","year":"2017","unstructured":"DiGiorgio, A. M. et al. Safety and effectiveness of early chemical deep venous thrombosis prophylaxis after spinal cord injury: pilot prospective data. Neurosurg. Focus 43, E21. https:\/\/doi.org\/10.3171\/2017.8.FOCUS17437 (2017).","journal-title":"Neurosurg. Focus"},{"key":"24717_CR29","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1177\/000313480507100504","volume":"71","author":"SP Stawicki","year":"2005","unstructured":"Stawicki, S. P. et al. Deep venous thrombosis and pulmonary embolism in trauma patients: An overstatement of the problem?. Am. Surg. 71, 387\u2013391 (2005).","journal-title":"Am. Surg."},{"key":"24717_CR30","doi-asserted-by":"publisher","first-page":"e349","DOI":"10.1097\/BOT.0000000000000336","volume":"29","author":"SJ Park","year":"2015","unstructured":"Park, S. J. et al. Incidence and factors predicting venous thromboembolism after surgical treatment of fractures below the hip. J. Orthop. Trauma 29, e349-354. https:\/\/doi.org\/10.1097\/BOT.0000000000000336 (2015).","journal-title":"J. Orthop. Trauma"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-24717-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-24717-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-24717-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T15:32:35Z","timestamp":1669303955000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-24717-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,23]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["24717"],"URL":"https:\/\/doi.org\/10.1038\/s41598-022-24717-1","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,23]]},"assertion":[{"value":"11 March 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 November 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 November 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"20206"}}