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We aimed to evaluate the feasibility of a Bayesian network (BN) model to predict the presence of simultaneous symptoms, based on the presence of other symptoms. Our goal is to help clinicians prioritize which symptoms to assess. Patient-reported severity of 11 symptoms (scale 0\u201310) was measured using an adapted Edmonton Symptom Assessment Scale (ESAS) in a national cross-sectional survey among advanced cancer patients. Scores were dichotomized (&lt;\u20094 and\u2009\u2265\u20094). Using fourfold cross validation, the prediction error of 9 BN algorithms was estimated (Akaike information criterion (AIC). The model with the highest AIC was evaluated. Model predictive performance was assessed per symptom; an area under curve (AUC) of\u2009\u2265\u20090.65 was considered satisfactory. Model calibration compared predicted and observed probabilities;\u2009&gt;\u200910% difference was considered inaccurate. Symptom scores of 532 patients were collected. A symptom score\u2009\u2265\u20094 was most prevalent for fatigue (64.7%). AUCs varied between 0.60 and 0.78, with satisfactory AUCs for 8\/11 symptoms. Calibration was accurate for 101\/110 predicted conditional probabilities. Whether a patient experienced fatigue was directly associated with experiencing 7 other symptoms. For example, in the absence or presence of fatigue, the model predicted a 8.6% and 33.1% probability of experiencing anxiety, respectively. It is feasible to use BN development for prioritizing symptom assessment. Fatigue seems most eligble to serve as a starting symptom for predicting the probability of experiencing simultaneous symptoms.\n<\/jats:p>","DOI":"10.1038\/s41598-022-26342-4","type":"journal-article","created":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T11:03:00Z","timestamp":1671879780000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The feasibility of a Bayesian network model to assess the probability of simultaneous symptoms in patients with advanced cancer"],"prefix":"10.1038","volume":"12","author":[{"given":"Lotte","family":"van der Stap","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myrthe F.","family":"van Haaften","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther F.","family":"van Marrewijk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert H.","family":"de Heij","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula L.","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janine M. 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