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It has been reported that patients with ASD show differential activity in cortical regions, for instance, increased neuronal activity in visual processing brain areas and atypical visual perception compared with healthy subjects. The causes of these alterations remain unclear, although many studies demonstrate that ASD has a strong genetic correlation. An example is Phelan\u2013McDermid syndrome, caused by a deletion of the Shank3 gene in one allele of chromosome 22. However, the neuronal consequences relating to the haploinsufficiency of Shank3 in the brain remain unknown. Given that sensory abnormalities are often present along with the core symptoms of ASD, our goal was to study the tuning properties of the primary visual cortex to orientation and direction in awake, head-fixed Shank3<jats:sup>+\/\u2212<\/jats:sup> mice. We recorded neural activity in vivo in response to visual gratings in the primary visual cortex from a mouse model of ASD (Shank3<jats:sup>+\/\u2212<\/jats:sup> mice) using the genetically encoded calcium indicator GCaMP6f, imaged with a two-photon microscope through a cranial window. We found that Shank3<jats:sup>+\/\u2212<\/jats:sup> mice showed a higher proportion of neurons responsive to drifting gratings stimuli than wild-type mice. Shank3<jats:sup>+\/\u2212<\/jats:sup> mice also show increased responses to some specific stimuli. Furthermore, analyzing the distributions of neurons for the tuning width, we found that Shank3<jats:sup>+\/\u2212<\/jats:sup> mice have narrower tuning widths, which was corroborated by analyzing the orientation selectivity. Regarding this, Shank3<jats:sup>+\/\u2212<\/jats:sup> mice have a higher proportion of selective neurons, specifically neurons showing increased selectivity to orientation but not direction. Thus, the haploinsufficiency of <jats:italic>Shank3<\/jats:italic> modified the neuronal response of the primary visual cortex.<\/jats:p>","DOI":"10.1038\/s41598-022-26402-9","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T13:05:07Z","timestamp":1671800707000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Haploinsufficiency of Shank3 increases the orientation selectivity of V1 neurons"],"prefix":"10.1038","volume":"12","author":[{"given":"Carlos Alberto","family":"Ortiz-Cruz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiliano Jimenez","family":"Marquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Iv\u00e1n","family":"Linares-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo Rodrigo","family":"Perera-Murcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yazm\u00edn","family":"Ramiro-Cort\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,23]]},"reference":[{"key":"26402_CR1","unstructured":"Association AP. in Diagnostic and statistical Manual of Mental Disorders (DSM-5\u00ae) (American Psychiatric Pub., 2013)."},{"key":"26402_CR2","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.neuron.2011.12.013","volume":"73","author":"BV Atallah","year":"2012","unstructured":"Atallah, B. 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