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Our aim is to investigate the association between serum VOCs and cotinine in smokers infected with HIV, HBV or HCV. National Health and Nutrition Examination Survey (NHANES 2005\u20132018) database, including 13,652 nationally representative subjects\u2019 sociodemographic characteristics and serological indicators, was used in this study. Smokers living with human immunodeficiency virus (HIV), hepatitis B virus (HBV) or hepatitis C virus (HCV) were compared to non-infected population. The correlation between VOCs and cotinine as well as the effects of VOCs on cotinine metabolism were analyzed by Spearman correlation analysis and multivariable logistic regression analysis, respectively. Among HIV, HBV, or HCV infected smokers with the largest exposure dose to tobacco, the intensity of the association between VOCs and cotinine was the strongest. The results of multivariable binary logistic regression showed that high concentrations of 1,2-Dichlorobenzene (OR:1.036, CI:1.009\u20131.124), Benzene (OR:1.478, CI:1.036\u20132.292), Carbon Tetrachloride (OR:1.576, CI:1.275\u20132.085) and 2,5-Dimethylfuran (OR:1.091, CI:1.030\u20131.157) in blood might be independent risk factors leading to the increase of serum metabolite cotinine in smokers.<\/jats:p>","DOI":"10.1038\/s41598-022-26420-7","type":"journal-article","created":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T13:23:16Z","timestamp":1671196996000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association between serum cotinine and volatile organic compounds (VOCs) in adults living with HIV, HBV, or HCV (NHANES 2005\u20132018)"],"prefix":"10.1038","volume":"12","author":[{"given":"Jie","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Long","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Wen","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,12,16]]},"reference":[{"key":"26420_CR1","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1093\/aje\/kwn301","volume":"169","author":"NL Benowitz","year":"2009","unstructured":"Benowitz, N. 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