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We hypothesized that cardiovagal baroreflex sensitivity (BRS) demonstrates different patterns in both sexes before and after 50\u00a0years of age and that these patterns are associated with patterned changes during the sleep\u2013wake cycle. We recruited 67 healthy participants (aged 20\u201379\u00a0years; 41 women) and divided them into four age groups: 20\u201329, 30\u201349, 50\u201369, and 70\u201379\u00a0years. All the participants underwent polysomnography and blood pressure measurements. For each participant, we used the average of the arterial pressure variability, heart rate variability (HRV), and BRS parameters during the sleep\u2013wake stages. BRS and HRV parameters were significantly negatively correlated with age. The BRS indexes were significantly lower in the participants aged\u2009\u2265\u200950\u00a0years than in those aged\u2009&lt;\u200950\u00a0years, and these age-related declines were more apparent during non-rapid eye movement sleep than during wakefulness. Only BRS demonstrated a significantly negative correlation with age in participants\u2009\u2265\u200950\u00a0years old. Women exhibited a stronger association than men between BRS and age and an earlier decline in BRS. Changes in BRS varied with age, sex, and consciousness state, each demonstrating a specific pattern. The age of 50\u00a0years appeared to be a crucial turning point for sexual dimorphism in BRS. Baroreflex modulation of the cardiovascular system during sleep sensitively delineated the age- and sex-dependent BRS patterns, highlighting the clinical importance of our results. Our findings may aid in screening for neurocardiac abnormalities in apparently healthy individuals.<\/jats:p>","DOI":"10.1038\/s41598-022-26440-3","type":"journal-article","created":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T11:02:59Z","timestamp":1672138979000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effects of age and sex on vasomotor activity and baroreflex sensitivity during the sleep\u2013wake cycle"],"prefix":"10.1038","volume":"12","author":[{"given":"Chia-Hsin","family":"Yeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry B. 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