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This retrospective study was conducted on 63 patients with ischemic MMD. Postoperative ischemia occurred in 15 of the 70 revascularization operations performed for patients after surgical revascularization, translating to an incidence of 21.4%. Univariate analysis revealed that onset infarction (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.015), posterior\u00a0cerebral\u00a0artery involvement (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.039), strict perioperative management (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001), interval time between transient ischemic attack (TIA) or infarction presentation and operation (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002) and preoperatively cerebral infarction extent score (CIES) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002) were significantly associated with postoperative cerebral ischemia. Multivariate analysis revealed that strict perioperative management (OR\u2009=\u20090.163;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.047), and preoperatively CIES (OR\u2009=\u20091.505;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.006) were independently associated with postoperative cerebral ischemia-related complications. After comprehensive improvement of perioperative management protocol, the incidence of symptomatic infarction declined to 7.4% (4 out of 54). Analysis of the area under the receiver operating characteristic curve (AUROC) indicated CIES was a predictor for both postoperative ischemia and high follow-up modified Rankin Scale scores. In summary, strict perioperative management and CIES were identified as independent risk factors for postoperative ischemic complications in ischemic MMD, demonstrating that comprehensive and individualized perioperative management improve postoperative outcomes in patients with MMD. Furthermore, application of CIES to evaluate pre-existing cerebral infarction can improve the management of patients.\n                  <\/jats:p>","DOI":"10.1038\/s41598-022-26985-3","type":"journal-article","created":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T11:03:06Z","timestamp":1680865386000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Risk factors and a novel cerebral infarction extent scoring system for postoperative cerebral ischemia in patients with ischemic Moyamoya disease"],"prefix":"10.1038","volume":"13","author":[{"given":"Yuanbing","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenghua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,4,7]]},"reference":[{"key":"26985_CR1","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1056\/NEJMra0804622","volume":"360","author":"RM Scott","year":"2009","unstructured":"Scott, R. 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