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Partitioning of salbutamol drug on the aqueous two-phase systems (ATPSs) of PEG<jats:sub>1000,1500,2000,4000,6000<\/jats:sub>\u2009+\u2009trilithium citrate\u2009+\u2009water was determined at <jats:italic>T<\/jats:italic>\u2009=\u2009298.15\u00a0K. The effect of molecular mass of polymer (MMP) on the binodal and tie-line compositions were studied. Results showed that the biphasic area was extended as the MMP was increased. The salting-out ability were quantified using the Setschenow model, and the binodal curves were modeled by a nonlinear 3-parameter equation. Furthermore, electrolyte Wilson along with the osmotic virial models have adequately been implemented to fit the tie-line compositions. Also, the studied ATPSs were implemented to study the partitioning of salbutamol drug on the salt-affluent and polymer-affluent phases. It is observed that, ATPSs of PEG<jats:sub>1000<\/jats:sub> is premium to extract the salbutamol to the polymer-affluent phase, where, the ATPSs of PEG<jats:sub>6000<\/jats:sub> is more favorable to extract the drug to the salt-affluent phase.<\/jats:p>","DOI":"10.1038\/s41598-023-28046-9","type":"journal-article","created":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T10:44:04Z","timestamp":1674125044000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Phase diagrams of PEG1000,1500,2000,4000,6000\u2009+\u2009lithium citrate\u2009+\u2009water ATPSs, and the partitioning of salbutamol at T\u2009=\u2009298.15\u00a0K"],"prefix":"10.1038","volume":"13","author":[{"given":"Ebrahim","family":"Nemati-Kande","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zolfa","family":"Azizi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marziyeh","family":"Mokarizadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,1,19]]},"reference":[{"key":"28046_CR1","doi-asserted-by":"publisher","first-page":"8826","DOI":"10.1016\/j.chroma.2011.06.051","volume":"1218","author":"JA Asenjo","year":"2011","unstructured":"Asenjo, J. 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