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We compared peak oxygen uptake (<jats:inline-formula><jats:alternatives><jats:tex-math>$${{\\dot{\\mathrm V}}}$$<\/jats:tex-math><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                  <mml:mover>\n                    <mml:mi>V<\/mml:mi>\n                    <mml:mo>\u02d9<\/mml:mo>\n                  <\/mml:mover>\n                <\/mml:math><\/jats:alternatives><\/jats:inline-formula>O<jats:sub>2peak<\/jats:sub>), a prognostic cardiovascular marker, and its determinants between long-term allo-SCT survivors and non-cancer controls. Fourteen allo-SCT survivors (mean\u2009\u00b1\u2009SD, 44\u2009\u00b1\u200915\u00a0years, 50% male, median time since allo-SCT: 6.5\u00a0years [range 2\u201320]) and 14 age-\u00a0and sex-matched controls (46\u2009\u00b1\u200913\u00a0years, 50% male) underwent cardiopulmonary exercise testing to quantify <jats:inline-formula><jats:alternatives><jats:tex-math>$${{\\dot{\\mathrm V}}}$$<\/jats:tex-math><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                  <mml:mover>\n                    <mml:mi>V<\/mml:mi>\n                    <mml:mo>\u02d9<\/mml:mo>\n                  <\/mml:mover>\n                <\/mml:math><\/jats:alternatives><\/jats:inline-formula>O<jats:sub>2peak<\/jats:sub>. Resting echocardiography (left-ventricular ejection fraction and strain), exercise cardiac MRI (peak cardiac and stroke volume index [CI<jats:sub>peak<\/jats:sub>, SVI<jats:sub>peak<\/jats:sub>]), biochemistry (hemoglobin, troponin-I, B-natriuretic peptide), dual-energy x-ray absorptiometry (lean [LM] and fat [FM] mass, percent body fat [%BF]) and <jats:italic>Fick<\/jats:italic>-<jats:italic>principal<\/jats:italic> calculation (arteriovenous oxygen difference) were also performed. Survivors exhibited impaired <jats:inline-formula><jats:alternatives><jats:tex-math>$${{\\dot{\\mathrm V}}}$$<\/jats:tex-math><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                  <mml:mover>\n                    <mml:mi>V<\/mml:mi>\n                    <mml:mo>\u02d9<\/mml:mo>\n                  <\/mml:mover>\n                <\/mml:math><\/jats:alternatives><\/jats:inline-formula>O<jats:sub>2peak<\/jats:sub> as compared with controls (25.9\u2009\u00b1\u20095.1 vs. 33.7\u2009\u00b1\u20096.5\u00a0ml\u00a0kg<jats:sup>\u22121<\/jats:sup>\u00a0min<jats:sup>\u22121<\/jats:sup>, <jats:italic>p<\/jats:italic>\u2009=\u20090.002), which coincided with reduced CI<jats:sub>peak<\/jats:sub> (6.6\u2009\u00b1\u20090.8 vs. 8.6\u2009\u00b1\u20091.9\u00a0L\u00a0min<jats:sup>\u22121<\/jats:sup>\u00a0m<jats:sup>\u22122<\/jats:sup>; <jats:italic>p<\/jats:italic>\u2009=\u20090.001) secondary to reduced SVI<jats:sub>peak<\/jats:sub> (48\u2009\u00b1\u20094 vs. 61\u2009\u00b1\u20098\u00a0ml\u00a0m<jats:sup>\u22122<\/jats:sup>; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) rather than chronotropic impairment, and higher %BF (difference, 7.9%, <jats:italic>p<\/jats:italic>\u2009=\u20090.007) due to greater FM (5.8\u00a0kg; <jats:italic>p<\/jats:italic>\u2009=\u20090.069) and lower LM (4.3\u00a0kg, <jats:italic>p<\/jats:italic>\u2009=\u20090.25). All other measures were similar between groups. Despite comparable resting cardiac function and biomarker profiles, survivors exhibited reduced <jats:inline-formula><jats:alternatives><jats:tex-math>$${{\\dot{\\mathrm V}}}$$<\/jats:tex-math><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                  <mml:mover>\n                    <mml:mi>V<\/mml:mi>\n                    <mml:mo>\u02d9<\/mml:mo>\n                  <\/mml:mover>\n                <\/mml:math><\/jats:alternatives><\/jats:inline-formula>O<jats:sub>2peak<\/jats:sub> and exercise cardiac function and increased %BF relative to controls. These results highlight potential therapeutic avenues and the utility of exercise-based cardiovascular assessment in unmasking cardiovascular dysfunction in allo-SCT survivors.\n<\/jats:p>","DOI":"10.1038\/s41598-023-28320-w","type":"journal-article","created":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T13:03:08Z","timestamp":1675688588000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Reduced cardiovascular reserve capacity in long-term allogeneic stem cell transplant survivors"],"prefix":"10.1038","volume":"13","author":[{"given":"Hayley T.","family":"Dillon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Foulkes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki A.","family":"Horne-Okano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Kliman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Dunstan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin M.","family":"Daly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve F.","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Avery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bronwyn A.","family":"Kingwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"La Gerche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin J.","family":"Howden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,2,6]]},"reference":[{"key":"28320_CR1","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.blre.2018.11.001","volume":"34","author":"EA Copelan","year":"2019","unstructured":"Copelan, E. 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