{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:16:26Z","timestamp":1790727386040,"version":"4.1.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T00:00:00Z","timestamp":1674777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T00:00:00Z","timestamp":1674777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"New Valley University"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The primary objective of this study was to describe the cytotoxicity on HEPG-2 cells and to study the COVID\u201119 activities of the novel H\n                    <jats:sub>2<\/jats:sub>\n                    L ligand and its Cr and Cu nano-complexes. As well as exploring the chemistry of the prepared nano-complexes. In this paper novel Schiff base, N-(4, 6-dimethyl pyrimidin-2-yl)-4-(((2-hydroxyl naphthalene-1-y l) methylene) amino) benzene\u2014sulfonamidesulfonyl) amide has been synthesized. The novel Schiff base H\n                    <jats:sub>2<\/jats:sub>\n                    L is used to synthesize novel nano and micro-complexes with CrCl\n                    <jats:sub>2<\/jats:sub>\n                    .6H\n                    <jats:sub>2<\/jats:sub>\n                    O and CuCl\n                    <jats:sub>2<\/jats:sub>\n                    .2H\n                    <jats:sub>2<\/jats:sub>\n                    O. The prepared ligand and micro complexes were interpreted by different spectroscopic techniques. The nano-sized Cr and Cu complexes were synthesized in an environmentally friendly manner using\n                    <jats:italic>Coriandrum sativum<\/jats:italic>\n                    (CS) media extract in ethanol. The structure, morphologies and particle size of the nano-sized complexes were determined using FT-IR, TEM, and PXRD. The results showed that the nano-domain complexes are on the Sub-nano scale. Furthermore, using TGA, we studied the effect of heat on the size of newly prepared nano-complexes. Experimental data were supported by DFT calculations. The findings revealed that the metal complexes investigated are more stable than the free ligand H\n                    <jats:sub>2<\/jats:sub>\n                    L. The antitumor activity was examined before and after heating the nano-complexes at 200\u00a0\u00b0C. The results reveal the Cr nano complex, after heating, exhibited strong antitumor activity with\u00a0IC\n                    <jats:sub>50<\/jats:sub>\n                    value (3.349\u00a0\u03bcg\/ml). The tested Cu nano-complex shows good DNA cleavage. The liver cancer and COVID19 proteins were examined using molecular docking to identify the potential binding energy of inhibitors.\n                  <\/jats:p>","DOI":"10.1038\/s41598-023-28402-9","type":"journal-article","created":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T06:03:30Z","timestamp":1674799410000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Synthesis of a new sulfadimidine Schiff base and their nano complexes as potential anti-COVID-19 and anti-cancer activity"],"prefix":"10.1038","volume":"13","author":[{"given":"Shimaa","family":"Hosny","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona S.","family":"Ragab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randa F.","family":"Abd El-Baki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,1,27]]},"reference":[{"key":"28402_CR1","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/S0956-7135(03)00100-2","volume":"15","author":"F de Zayas-Blanco","year":"2004","unstructured":"de Zayas-Blanco, F., Garica-Falc\u00f3n, M. & Simal-G\u00e1ndara, J. Determination of sulfamethazine in milk by solid phase extraction and liquid chromatographic separation with ultraviolet detection. Food Control 15, 375\u2013378 (2004).","journal-title":"Food Control"},{"key":"28402_CR2","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1126\/science.1214641","volume":"335","author":"M-K Yun","year":"2012","unstructured":"Yun, M.-K. et al. Catalysis and sulfa drug resistance in dihydropteroate synthase. Science 335, 1110\u20131114 (2012).","journal-title":"Science"},{"key":"28402_CR3","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1016\/j.saa.2012.07.102","volume":"97","author":"AM Tawfik","year":"2012","unstructured":"Tawfik, A. M., El-Ghamry, M. A., Abu-El-Wafa, S. M. & Ahmed, N. M. A new bioactive Schiff base ligands derived from propylazo-N-pyrimidin-2-yl-benzenesulfonamides Mn(II) and Cu(II) complexes: Synthesis, thermal and spectroscopic characterization biological studies and 3D modeling structures. Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 97, 1172\u20131180 (2012).","journal-title":"Spectrochim. Acta. A. Mol. Biomol. Spectrosc."},{"key":"28402_CR4","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.molstruc.2013.02.028","volume":"1040","author":"AM Mansour","year":"2013","unstructured":"Mansour, A. M. & Ghani, N. T. A. Hydrogen-bond effect, spectroscopic and molecular structure investigation of sulfamethazine Schiff-base: Experimental and quantum chemical calculations. J. Mol. Struct. 1040, 226\u2013237 (2013).","journal-title":"J. Mol. Struct."},{"key":"28402_CR5","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.molstruc.2012.09.048","volume":"1035","author":"AM Mansour","year":"2013","unstructured":"Mansour, A. M. Molecular structure and spectroscopic properties of novel manganese (II) complex with sulfamethazine drug. J. Mol. Struct. 1035, 114\u2013123 (2013).","journal-title":"J. Mol. Struct."},{"key":"28402_CR6","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1080\/00958972.2013.775427","volume":"66","author":"A Mansour","year":"2013","unstructured":"Mansour, A. Experimental and quantum chemical studies of sulfamethazine complexes with Ni(II) and Cu(II) ions. J. Coord. Chem. 66, 1118\u20131128 (2013).","journal-title":"J. Coord. Chem."},{"key":"28402_CR7","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/S0022-2860(03)00202-3","volume":"654","author":"C Topacli","year":"2003","unstructured":"Topacli, C. & Topacli, A. PM3 semi-empirical IR spectra simulations for metal complexes of schiff bases of sulfa drugs. J. Mol. Struct. 654, 131\u2013137 (2003).","journal-title":"J. Mol. Struct."},{"key":"28402_CR8","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.5995","volume":"34","author":"AM Mansour","year":"2020","unstructured":"Mansour, A. M., Abdel-Ghani, N. T. & Ragab, M. S. DNA\/bovine serum albumin binding and cytotoxicity of transition metal ternary complexes based on sulfamethazine and bromazepam drugs. Appl. Organomet. Chem. 34, e5995 (2020).","journal-title":"Appl. Organomet. Chem."},{"key":"28402_CR9","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.dyepig.2012.05.005","volume":"95","author":"G G\u00fcmr\u00fck\u00e7\u00fc","year":"2012","unstructured":"G\u00fcmr\u00fck\u00e7\u00fc, G., Karao\u011flan, G. K., Erdo\u011fmu\u015f, A., G\u00fcl, A. & Avc\u0131ata, U. A novel phthalocyanine conjugated with four salicylideneimino complexes: Photophysics and fluorescence quenching studies. Dyes Pigm. 95, 280\u2013289 (2012).","journal-title":"Dyes Pigm."},{"key":"28402_CR10","doi-asserted-by":"publisher","first-page":"191","DOI":"10.3390\/antibiotics11020191","volume":"11","author":"J Ceramella","year":"2022","unstructured":"Ceramella, J. et al. A review on the antimicrobial activity of schiff bases: Data collection and recent studies. Antibiotics 11, 191 (2022).","journal-title":"Antibiotics"},{"key":"28402_CR11","doi-asserted-by":"publisher","first-page":"298","DOI":"10.4236\/ijoc.2018.83022","volume":"8","author":"M Kuate","year":"2018","unstructured":"Kuate, M. et al. Synthesis, characterization and antimicrobial studies of Co(II), Ni(II), Cu(II) and Zn(II) complexes of (E)-2-(4-dimethylbenzydimino)-glycylglycine,(glygly-DAB) a schiff base derived from 4-dimethylaminobenzaldehyde and glycylglycine. IJOC 8, 298 (2018).","journal-title":"IJOC"},{"key":"28402_CR12","doi-asserted-by":"publisher","first-page":"e6802","DOI":"10.1002\/aoc.6802","volume":"36","author":"MS Ragab","year":"2022","unstructured":"Ragab, M. S., Soliman, M. H., Shehata, M. R., Shoukry, M. M. & Ragheb, M. A. Design, synthesis, spectral characterization, photo-cleavage and in vitro evaluation of anticancer activities of new transition metal complexes of piperazine based Schiff base-oxime ligand. Appl. Organomet. Chem. 36, e6802 (2022).","journal-title":"Appl. Organomet. Chem."},{"issue":"10","key":"28402_CR13","doi-asserted-by":"publisher","first-page":"e6843","DOI":"10.1002\/aoc.6843","volume":"36","author":"HA Elbadawy","year":"2022","unstructured":"Elbadawy, H. A., Abd-El-Nabey, B. A., Ali, A. E. D. & Elsayed, E. H. The development of an unexpected Cu(I)-pyrazolo pyrimidine-based complex: Synthesis, spectroscopic characterizations, and biological activity. Appl. Organomet. Chem. 36(10), e6843 (2022).","journal-title":"Appl. Organomet. Chem."},{"key":"28402_CR14","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.saa.2009.10.039","volume":"75","author":"SA Patil","year":"2010","unstructured":"Patil, S. A., Naik, V. H., Kulkarni, A. D. & Badami, P. S. DNA cleavage, antimicrobial, spectroscopic and fluorescence studies of Co(II), Ni(II) and Cu(II) complexes with SNO donor coumarin Schiff bases. Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 75, 347\u2013354 (2010).","journal-title":"Spectrochim. Acta. A. Mol. Biomol. Spectrosc."},{"key":"28402_CR15","doi-asserted-by":"publisher","first-page":"116498","DOI":"10.1016\/j.molliq.2021.116498","volume":"334","author":"KS Abou-Melha","year":"2021","unstructured":"Abou-Melha, K. S. et al. Synthesis, characterization, DFT calculation, DNA binding and antimicrobial activities of metal complexes of dimedone arylhydrazone. J. Mol. Liq. 334, 116498 (2021).","journal-title":"J. Mol. Liq."},{"key":"28402_CR16","doi-asserted-by":"publisher","first-page":"e4687","DOI":"10.1002\/aoc.4687","volume":"33","author":"N Zare","year":"2019","unstructured":"Zare, N. & Zabardasti, A. A new nano-sized mononuclear Cu (II) complex with N, N-donor Schiff base ligands: sonochemical synthesis, characterization, molecular modeling and biological activity. Appl. Organomet. Chem. 33, e4687 (2019).","journal-title":"Appl. Organomet. Chem."},{"key":"28402_CR17","doi-asserted-by":"publisher","first-page":"101113","DOI":"10.1016\/j.surfin.2021.101113","volume":"24","author":"MF Al-Hakkani","year":"2021","unstructured":"Al-Hakkani, M. F., Gouda, G. A., Hassan, S. H. & Nagiub, A. M. Echinacea purpurea mediated hematite nanoparticles (\u03b1-HNPs) biofabrication, characterization, physicochemical properties, and its in-vitro biocompatibility evaluation. Surf. Interfaces 24, 101113 (2021).","journal-title":"Surf. Interfaces"},{"key":"28402_CR18","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1515\/ntrev-2022-0034","volume":"11","author":"M Madani","year":"2022","unstructured":"Madani, M. et al. Green synthesis of nanoparticles for varied applications: Green renewable resources and energy-efficient synthetic routes. Nanotechnol. Rev. 11, 731\u2013759 (2022).","journal-title":"Nanotechnol. Rev."},{"key":"28402_CR19","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.3390\/life12091341","volume":"12","author":"JY Al-Humaidi","year":"2022","unstructured":"Al-Humaidi, J. Y. et al. 1, 2, 3-triazole-benzofused molecular conjugates as potential antiviral agents against SARS-CoV-2 virus variants. Life 12, 1341 (2022).","journal-title":"Life"},{"key":"28402_CR20","doi-asserted-by":"publisher","first-page":"799","DOI":"10.3390\/ph15070799","volume":"15","author":"FF Albelwi","year":"2022","unstructured":"Albelwi, F. F. et al. Design, synthesis and molecular docking of novel acetophenone-1, 2, 3-triazoles containing compounds as potent enoyl-acyl carrier protein reductase (InhA) inhibitors. Pharmaceuticals 15, 799 (2022).","journal-title":"Pharmaceuticals"},{"key":"28402_CR21","doi-asserted-by":"publisher","first-page":"3922","DOI":"10.3390\/ijms21113922","volume":"21","author":"M Hagar","year":"2020","unstructured":"Hagar, M., Ahmed, H. A., Aljohani, G. & Alhaddad, O. A. Investigation of some antiviral N-heterocycles as COVID 19 drug: molecular docking and DFT calculations. Int. J. Mol. Sci. 21, 3922 (2020).","journal-title":"Int. J. Mol. Sci."},{"key":"28402_CR22","doi-asserted-by":"publisher","first-page":"5429","DOI":"10.1080\/07391102.2019.1701555","volume":"38","author":"RB Alnoman","year":"2020","unstructured":"Alnoman, R. B., Parveen, S., Hagar, M., Ahmed, H. A. & Knight, J. G. A new chiral boron-dipyrromethene (BODIPY)-based fluorescent probe: Molecular docking, DFT, antibacterial and antioxidant approaches. Biomol. Struct. Dyn. 38, 5429\u20135442 (2020).","journal-title":"Biomol. Struct. Dyn."},{"key":"28402_CR23","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1021\/acsomega.0c04595","volume":"6","author":"A Al Sheikh Ali","year":"2020","unstructured":"Al Sheikh Ali, A. et al. Design, synthesis, molecular modeling, anticancer studies, and density functional theory calculations of 4-(1, 2, 4-triazol-3-ylsulfanylmethyl)-1, 2, 3-triazole derivatives. ACS Omega 6, 301\u2013316 (2020).","journal-title":"ACS Omega"},{"key":"28402_CR24","doi-asserted-by":"publisher","first-page":"4034","DOI":"10.1080\/10406638.2021.1878245","volume":"42","author":"FF Mohammed","year":"2022","unstructured":"Mohammed, F. F. et al. 2-(alkylthio)-3-(naphthalen-1-yl) quinazolin-4 (3 H)-ones: Ultrasonic synthesis, DFT and molecular docking aspects. Polycycl. Aromat. Compd. 42, 4034\u20134048 (2022).","journal-title":"Polycycl. Aromat. Compd."},{"key":"28402_CR25","doi-asserted-by":"publisher","first-page":"112508","DOI":"10.1016\/j.jphotochem.2020.112508","volume":"395","author":"RB Alnoman","year":"2020","unstructured":"Alnoman, R. B., Hagar, M., Parveen, S., Ahmed, H. A. & Knight, J. G. Computational and molecular docking approaches of a New axially chiral BODIPY fluorescent dye. J. Photochem. Photobiol. A Chem. 395, 112508 (2020).","journal-title":"J. Photochem. Photobiol. A Chem."},{"key":"28402_CR26","doi-asserted-by":"publisher","first-page":"13163","DOI":"10.1002\/slct.202003621","volume":"5","author":"S Parveen","year":"2020","unstructured":"Parveen, S., Alnoman, R. B., Hagar, M., Ahmed, H. A. & Knight, J. G. Synthesis, molecular docking, and DFT calculation of a half-strapped BODIPY as potential EGFR inhibitor. ChemistrySelect 5, 13163\u201313173 (2020).","journal-title":"ChemistrySelect"},{"key":"28402_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2021.131312","volume":"1247","author":"RB Alnoman","year":"2022","unstructured":"Alnoman, R. B., Parveen, S., Khan, A., Knight, J. G. & Hagar, M. New quinoline-based BODIPYs as EGFR\/VEGFR-2 inhibitors: Molecular docking, DFT and in vitro cytotoxicity on HeLa cells. J. Mol. Struct. 1247, 131312 (2022).","journal-title":"J. Mol. Struct."},{"key":"28402_CR28","doi-asserted-by":"publisher","first-page":"252","DOI":"10.3389\/fchem.2021.672503","volume":"9","author":"MH Abdellattif","year":"2021","unstructured":"Abdellattif, M. H. et al. Novel 2-hydroselenonicotinonitriles and selenopheno [2, 3-b] pyridines: Efficient synthesis, molecular docking-DFT modeling, and antimicrobial assessment. Front. Chem. 9, 252 (2021).","journal-title":"Front. Chem."},{"key":"28402_CR29","doi-asserted-by":"publisher","first-page":"126926","DOI":"10.1016\/j.molstruc.2019.126926","volume":"1199","author":"M Hagar","year":"2020","unstructured":"Hagar, M., Chaieb, K., Parveen, S., Ahmed, H. & Alnoman, R. N-alkyl 2-pyridone versus O-alkyl 2-pyridol: Ultrasonic synthesis, DFT, docking studies and their antimicrobial evaluation. J. Mol. Struct. 1199, 126926 (2020).","journal-title":"J. Mol. Struct."},{"key":"28402_CR30","doi-asserted-by":"publisher","first-page":"3736","DOI":"10.1080\/10406638.2021.1871636","volume":"42","author":"S Parveen","year":"2022","unstructured":"Parveen, S. et al. Synthesis, docking and density functional theory approaches on 1, 3-Bis-3-(4-Chlorophenyl)-2, 3-dihydroquinazolin-4 (1H)-on-2-thioxopropane toward the discovery of dual kinase inhibitor. Polycycl. Aromat. Compd. 42, 3736\u20133747 (2022).","journal-title":"Polycycl. Aromat. Compd."},{"key":"28402_CR31","doi-asserted-by":"publisher","first-page":"130235","DOI":"10.1016\/j.molstruc.2021.130235","volume":"1235","author":"MA El-ghamry","year":"2021","unstructured":"El-ghamry, M. A., Nassir, K. M., Elzawawi, F. M., Aziz, A. A. A. & Abu-El-Wafa, S. M. Novel nanoparticle-size metal complexes derived from acyclovir. Spectroscopic characterization, thermal analysis, antitumor screening, and DNA cleavage, as well as 3D modeling, docking, and electrical conductivity studies. J. Mol. Struct. 1235, 130235 (2021).","journal-title":"J. Mol. Struct."},{"key":"28402_CR32","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1002\/qua.24438","volume":"113","author":"M Frisch","year":"2013","unstructured":"Frisch, M. et al. Gaussian 09, Revision D. 01; Gaussian, Inc.: Wallingford, CT, 2013. Google Scholar There is no corresponding record for this reference. (b) Laurent, AD; Jacquemin, D. Int. J. Quantum Chem. 113, 2019\u20132039 (2013).","journal-title":"Int. J. Quantum Chem."},{"key":"28402_CR33","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1039\/D1RA07793G","volume":"12","author":"MS Ragab","year":"2022","unstructured":"Ragab, M. S., Shehata, M. R., Shoukry, M. M., Haukka, M. & Ragheb, M. A. Oxidative DNA cleavage mediated by a new unexpected [Pd (BAPP)][PdCl 4] complex (BAPP= 1, 4-bis (3-aminopropyl) piperazine): crystal structure, DNA binding and cytotoxic behavior. RSC Adv. 12, 1871\u20131884 (2022).","journal-title":"RSC Adv."},{"key":"28402_CR34","unstructured":"Inc., C. C. G. (Chemical Computing Group Inc. Montreal, QC, Canada, 2016)."},{"key":"28402_CR35","doi-asserted-by":"publisher","first-page":"2104","DOI":"10.1073\/pnas.1510959113","volume":"113","author":"B Murray","year":"2016","unstructured":"Murray, B. et al. Crystallography captures catalytic steps in human methionine adenosyltransferase enzymes. PNAS 113, 2104\u20132109 (2016).","journal-title":"PNAS"},{"key":"28402_CR36","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1038\/s41586-020-2223-y","volume":"582","author":"Z Jin","year":"2020","unstructured":"Jin, Z. et al. Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors. Nature 582, 289\u2013293 (2020).","journal-title":"Nature"},{"key":"28402_CR37","doi-asserted-by":"publisher","first-page":"e6627","DOI":"10.1002\/aoc.6627","volume":"36","author":"S Hosny","year":"2022","unstructured":"Hosny, S., Gouda, G. A. & Abu-El-Wafa, S. M. Novel nano copper complexes of a new Schiff base: green synthesis, a new series of solid Cr(II), Co(II), Cu(II), Pd(II) and Cd(II) chelates, characterization, DFT, DNA, antitumor and molecular docking studies. Appl. Organomet. Chem. 36, e6627 (2022).","journal-title":"Appl. Organomet. Chem."},{"key":"28402_CR38","doi-asserted-by":"publisher","first-page":"2192","DOI":"10.1080\/00958972.2015.1055258","volume":"68","author":"SM Tailor","year":"2015","unstructured":"Tailor, S. M. & Patel, U. H. Synthesis, spectroscopic characterization, antimicrobial activity and crystal structure of silver and copper complexes of sulfamethazine. J. Coord. Chem. 68, 2192\u20132207 (2015).","journal-title":"J. Coord. Chem."},{"key":"28402_CR39","doi-asserted-by":"publisher","first-page":"25118","DOI":"10.1007\/s10854-021-06967-3","volume":"32","author":"M Fazli","year":"2021","unstructured":"Fazli, M., Akbarzadeh-T, N., Beitollahi, H., Du\u0161ek, M. & Eigner, V. New Schiff base ligand N-(2-hydroxy-1-naphthylidene)-2-methyl aniline and its nano-sized copper (II) complex: synthesis, characterization, crystal structure and application as an electrochemical sensor of 2-phenylphenol in the presence of 4-chlorophenol. J. Mater. Sci. Mater. Electron. 32, 25118\u201325136 (2021).","journal-title":"J. Mater. Sci. Mater. Electron."},{"key":"28402_CR40","doi-asserted-by":"publisher","first-page":"3595","DOI":"10.1007\/s10904-020-01505-w","volume":"30","author":"R Shah","year":"2020","unstructured":"Shah, R. et al. Synthesis and structural elucidation for new Schiff base complexes; conductance, conformational, MOE-docking and biological studies. J. Inorg. Organomet. Polym. Mater. 30, 3595\u20133607 (2020).","journal-title":"J. Inorg. Organomet. Polym. Mater."},{"key":"28402_CR41","doi-asserted-by":"crossref","first-page":"2","DOI":"10.20964\/2021.12.14","volume":"16","author":"GA Gaber","year":"2021","unstructured":"Gaber, G. A., Hosny, S. & Mohamed, L. Z. Experimental and theoretical studies of 2-cyano-N-(4-morpholinobenzyldine) acetohydrazide as corrosion inhibitor for galvanized steel and 304 stainless steel in 1M H2SO4 solution. Int. J. Electrochem. Sci. 16, 2 (2021).","journal-title":"Int. J. Electrochem. Sci."},{"key":"28402_CR42","first-page":"2","volume":"17","author":"HM Al-Saidi","year":"2022","unstructured":"Al-Saidi, H. M. et al. Synthesis and characterization of Ni(II), Cu(II), Zn(II) and Azo dye based on 1, 10-o-phenanthroline binary complexes: Corrosion inhibition properties and computational studies. Int. J. Electrochem. Sci. 17, 2 (2022).","journal-title":"Int. J. Electrochem. Sci."},{"key":"28402_CR43","doi-asserted-by":"publisher","first-page":"114057","DOI":"10.1016\/j.jpba.2021.114057","volume":"199","author":"MI Morsy","year":"2021","unstructured":"Morsy, M. I. et al. A novel LC-MS\/MS method for determination of the potential antiviral candidate favipiravir for the emergency treatment of SARS-CoV-2 virus in human plasma: Application to a bioequivalence study in Egyptian human volunteers. J. Pharm. Biomed. Anal. 199, 114057. https:\/\/doi.org\/10.1016\/j.jpba.2021.114057 (2021).","journal-title":"J. Pharm. Biomed. Anal."},{"key":"28402_CR44","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.saa.2013.12.066","volume":"123","author":"AM Mansour","year":"2014","unstructured":"Mansour, A. M. Selective coordination ability of sulfamethazine Schiff-base ligand towards copper (II): Molecular structures, spectral and SAR study. Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 123, 257\u2013266 (2014).","journal-title":"Spectrochim. Acta. A. Mol. Biomol. Spectrosc."},{"key":"28402_CR45","doi-asserted-by":"publisher","first-page":"9794","DOI":"10.1039\/C6DT00279J","volume":"45","author":"M Yousif","year":"2016","unstructured":"Yousif, M., Cabelof, A. C., Martin, P. D., Lord, R. L. & Groysman, S. Synthesis of a mononuclear, non-square-planar chromium (ii) bis (alkoxide) complex and its reactivity toward organic carbonyls and CO2. Dalton Trans. 45, 9794\u20139804 (2016).","journal-title":"Dalton Trans."},{"key":"28402_CR46","first-page":"164","volume":"55","author":"S-U Rehman","year":"2011","unstructured":"Rehman, S.-U., Ikram, M., Rehman, S., Islam, N. U. & Jan, N. Synthesis and characterization of Ni(II), Cu(II) and Zn(II) tetrahedral transition metal complexes of modified hydrazine. J. Mex. Chem. Soc. 55, 164\u2013167 (2011).","journal-title":"J. Mex. Chem. Soc."},{"key":"28402_CR47","doi-asserted-by":"publisher","first-page":"9634","DOI":"10.1021\/acs.inorgchem.7b01154","volume":"56","author":"I Shimizu","year":"2017","unstructured":"Shimizu, I. et al. Tetrahedral copper (II) complexes with a labile coordination site supported by a Tris-tetramethylguanidinato ligand. Inorg. Chem. 56, 9634\u20139645 (2017).","journal-title":"Inorg. Chem."},{"key":"28402_CR48","doi-asserted-by":"publisher","first-page":"4797","DOI":"10.1021\/cr0680282","volume":"107","author":"SK Ghosh","year":"2007","unstructured":"Ghosh, S. K. & Pal, T. Interparticle coupling effect on the surface plasmon resonance of gold nanoparticles: from theory to applications. Chem. Rev. 107, 4797\u20134862 (2007).","journal-title":"Chem. Rev."},{"key":"28402_CR49","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.ica.2012.05.006","volume":"391","author":"A Onder","year":"2012","unstructured":"Onder, A., Turkyilmaz, M. & Baran, Y. Synthesis, spectroscopic, magnetic and thermal properties of copper (II), nickel (II) and iron (II) complexes with some tetradentate ligands: Solvatochromism of iron (II)\u2013L2. Inorg. Chim. Acta 391, 28\u201335 (2012).","journal-title":"Inorg. Chim. Acta"},{"key":"28402_CR50","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/j.molstruc.2018.08.095","volume":"1176","author":"AE Ali","year":"2019","unstructured":"Ali, A. E., Elasala, G. S. & Ibrahim, R. S. Synthesis, characterization, spectral, thermal analysis and biological activity studies of metronidazole complexes. J. Mol. Struct. 1176, 673\u2013684 (2019).","journal-title":"J. Mol. Struct."},{"key":"28402_CR51","first-page":"9","volume":"64","author":"WT Shier","year":"1991","unstructured":"Shier, W. T. Mammalian cell culture on $5 a day: A laboratory manual of low cost methods. Los Banos Univ. Philipp. 64, 9\u201316 (1991).","journal-title":"Los Banos Univ. Philipp."},{"key":"28402_CR52","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.jinorgbio.2014.02.014","volume":"135","author":"M Grazul","year":"2014","unstructured":"Grazul, M. et al. Synthesis, physico-chemical properties and biological analysis of newly obtained copper (II) complexes with pyrazole derivatives. J. Inorg. Biochem. 135, 68\u201376 (2014).","journal-title":"J. Inorg. Biochem."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-023-28402-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-023-28402-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-023-28402-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T13:38:30Z","timestamp":1701783510000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-023-28402-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,27]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["28402"],"URL":"https:\/\/doi.org\/10.1038\/s41598-023-28402-9","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,27]]},"assertion":[{"value":"8 August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 January 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 January 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1502"}}