{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:54:42Z","timestamp":1789750482868,"version":"4.0.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T00:00:00Z","timestamp":1674432000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T00:00:00Z","timestamp":1674432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study aimed to compare clinical parameters, including final adult height (FAH), in girls with central precocious puberty treated with gonadotropin-releasing hormone agonists (GnRHa) with and without growth hormone (GH). This retrospective study reviewed data of 210 girls with precocious puberty who had reached FAH in a long-term trial of GnRHa treatment. The subjects were divided into the GnRHa treatment group (n\u2009=\u2009188), and the combined GnRHa\u2009+\u2009GH treatment group (n\u2009=\u200922). Chronological age, bone age, height, height standard deviation score, predicted adult height (PAH), FAH, Tanner stage, and hormone levels were assessed during the treatment period. At the start of treatment, PAH was 156.35\u2009\u00b1\u20096.34\u00a0cm in the GnRHa monotherapy group and 150.41\u2009\u00b1\u20095.32\u00a0cm in the GnRHa\u2009+\u2009GH group (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001). At the end of treatment, PAH was 166.25\u2009\u00b1\u20095.26\u00a0cm in the GnRHa group and 164.07\u2009\u00b1\u20094.99\u00a0cm in the combined GnRHa\u2009+\u2009GH treatment group, which had increased compared to the start of treatment. The FAH in the GnRHa group and GnRHa\u2009+\u2009GH combination group were 161.07\u2009\u00b1\u20094.78\u00a0cm and 159.63\u2009\u00b1\u20093.8 6\u00a0cm, respectively, without significant difference. In addition, the height gain (FAH\u2013PAH) was significantly higher in the GnRHa\u2009+\u2009GH group than the GnRHa group (9.22\u2009\u00b1\u20096.03\u00a0cm vs. 4.72\u2009\u00b1\u20095.01\u00a0cm,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001). In girls with central precocious puberty, the height gain in the FAH compared to PAH at the start of treatment was significantly higher with the GnRHa\u2009+\u2009GH combination treatment.\n                  <\/jats:p>","DOI":"10.1038\/s41598-023-28602-3","type":"journal-article","created":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T05:02:54Z","timestamp":1674450174000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Effect of gonadotropin-releasing hormone agonist monotherapy and combination therapy with growth hormone on final adult height in girls with central precocious puberty"],"prefix":"10.1038","volume":"13","author":[{"given":"Ah Young","family":"Cho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Suk","family":"Shim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae Sang","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Soon","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,1,23]]},"reference":[{"key":"28602_CR1","doi-asserted-by":"publisher","first-page":"S172","DOI":"10.4103\/2230-8210.84855","volume":"15","author":"A Bajpai","year":"2011","unstructured":"Bajpai, A. & Menon, P. 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