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Fifty-one children [57 eyes; median age, 11\u00a0years; 51% female; median follow-up period, 36\u00a0months (interquartile range 14.9\u201364.4)] aged\u2009\u2264\u200916\u00a0years with uveitis managed at our tertiary center from January 2010 to July 2020 were reviewed. Uveitis mainly manifested as unilateral (74.5%), chronic course (82.4%), and panuveitis (43.1%). Ocular toxoplasmosis and toxocariasis were the most common diagnoses (9.8% each). At least one ocular complication at presentation was observed in 93% of the eyes. Overall, the mean logMAR VA improved from 1.8 at presentation to 1.2 at 5\u00a0years (P\u2009&lt;\u20090.001). Common causes of poor vision included retinal detachment, atrophic bulbi, and optic atrophy. Predictive factors associated with less VA improvement over the follow-up period included preschool age of uveitis onset (P\u2009&lt;\u20090.001), ocular symptoms duration before uveitis diagnosis\u2009\u2265\u20091\u00a0month (P\u2009=\u20090.004), and non-anterior uveitis (P\u2009=\u20090.047). The long-term VA outcome in uveitis-affected eyes with SVI at presentation was unfavorable. Younger age at uveitis onset, delayed presentation, and uveitis involving the posterior segment were associated with poorer VA outcome.<\/jats:p>","DOI":"10.1038\/s41598-023-29159-x","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T10:05:24Z","timestamp":1676887524000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Long-term visual acuity outcome of pediatric uveitis patients presenting with severe visual impairment"],"prefix":"10.1038","volume":"13","author":[{"given":"Usanee","family":"Tungsattayathitthan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narisa","family":"Rattanalert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1142-0345","authenticated-orcid":false,"given":"Wantanee","family":"Sittivarakul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,2,20]]},"reference":[{"key":"29159_CR1","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1076\/ocii.8.4.251.6459","volume":"8","author":"ET Cunningham","year":"2000","unstructured":"Cunningham, E. 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