{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:27:07Z","timestamp":1783607227902,"version":"3.55.0"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T00:00:00Z","timestamp":1677024000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T00:00:00Z","timestamp":1677024000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Parkinson\u2019s disease (PD) is a common neurological disorder that causes quiescent tremors, motor delays, depression, and sleep disturbances. Existing treatments can only improve symptoms, not stop progression or cure the disease, but effective treatments can significantly improve patients\u2019 quality of life. There is growing evidence that chromatin regulatory proteins (CRs) are involved in a variety of biological processes, including inflammation, apoptosis, autophagy, and proliferation. But the relationship of chromatin regulators in Parkinson\u2019s disease has not been studied. Therefore, we aim to investigate the role of CRs in the pathogenesis of Parkinson\u2019s disease. We collected 870 chromatin regulatory factors from previous studies and downloaded data on patients with PD from the GEO database. 64 differentially expressed genes were screened, the interaction network was constructed and the key genes with the top 20 scores were calculated. Then we discussed its correlation with the immune function of PD. Finally, we screened potential drugs and miRNAs. Five genes related to the immune function of PD, BANF1, PCGF5, WDR5, RYBP and BRD2, were obtained by using the absolute value of correlation greater than 0.4. And the disease prediction model showed good predictive efficiency. We also screened 10 related drugs and 12 related miRNAs, which provided a reference for the treatment of PD. BANF1, PCGF5, WDR5, RYBP and BRD2 are related to the immune process of Parkinson\u2019s disease and can predict the occurrence of Parkinson\u2019s disease, which is expected to become a new target for the diagnosis and treatment of Parkinson\u2019s disease.<\/jats:p>","DOI":"10.1038\/s41598-023-30236-4","type":"journal-article","created":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T06:03:04Z","timestamp":1677045784000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Identification of Parkinson\u2019s disease-associated chromatin regulators"],"prefix":"10.1038","volume":"13","author":[{"given":"Hailong","family":"Xing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,2,22]]},"reference":[{"issue":"10291","key":"30236_CR1","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1016\/S0140-6736(21)00218-X","volume":"397","author":"BR Bloem","year":"2021","unstructured":"Bloem, B. R., Okun, M. S. & Klein, C. Parkinson\u2019s disease. Lancet 397(10291), 2284\u20132303 (2021).","journal-title":"Lancet"},{"issue":"2","key":"30236_CR2","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.mcna.2018.10.014","volume":"103","author":"SG Reich","year":"2019","unstructured":"Reich, S. G. & Savitt, J. M. Parkinson\u2019s disease. Med. Clin. N. Am. 103(2), 337\u2013350 (2019).","journal-title":"Med. Clin. N. Am."},{"issue":"10","key":"30236_CR3","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1002\/mds.26747","volume":"31","author":"DA Figge","year":"2016","unstructured":"Figge, D. A. & Standaert, D. G. SNPing SCNA regulatory elements gives a CRISPR view of genetic susceptibility in Parkinson\u2019s disease. Movement Disord. 31(10), 1479\u20131479 (2016).","journal-title":"Movement Disord."},{"issue":"4","key":"30236_CR4","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.tibs.2020.11.007","volume":"46","author":"AB Malpartida","year":"2021","unstructured":"Malpartida, A. B., Williamson, M., Narendra, D. P., Wade-Martins, R. & Ryan, B. J. Mitochondrial dysfunction and mitophagy in Parkinson\u2019s disease: From mechanism to therapy. Trends Biochem. Sci. 46(4), 329\u2013343 (2021).","journal-title":"Trends Biochem. Sci."},{"issue":"2","key":"30236_CR5","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/S1474-4422(19)30287-X","volume":"19","author":"C Blauwendraat","year":"2020","unstructured":"Blauwendraat, C., Nalls, M. A. & Singleton, A. B. The genetic architecture of Parkinson\u2019s disease. Lancet Neurol. 19(2), 170\u2013178 (2020).","journal-title":"Lancet Neurol."},{"key":"30236_CR6","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.arr.2017.12.007","volume":"42","author":"H Deng","year":"2018","unstructured":"Deng, H., Wang, P. & Jankovic, J. The genetics of Parkinson disease. Ageing Res. Rev. 42, 72\u201385 (2018).","journal-title":"Ageing Res. Rev."},{"issue":"5","key":"30236_CR7","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1128\/MCB.00660-20","volume":"41","author":"A Usmani","year":"2021","unstructured":"Usmani, A., Shavarebi, F. & Hiniker, A. The cell biology of LRRK2 in Parkinson\u2019s disease. Mol. Cell Biol. 41(5), 100. https:\/\/doi.org\/10.1128\/MCB.00660-20 (2021).","journal-title":"Mol. Cell Biol."},{"issue":"7","key":"30236_CR8","doi-asserted-by":"publisher","first-page":"3119","DOI":"10.1007\/s12035-021-02327-8","volume":"58","author":"L Streubel-Gallasch","year":"2021","unstructured":"Streubel-Gallasch, L. et al. Parkinson\u2019s disease-associated LRRK2 interferes with astrocyte-mediated alpha-synuclein clearance. Mol. Neurobiol. 58(7), 3119\u20133140 (2021).","journal-title":"Mol. Neurobiol."},{"issue":"1","key":"30236_CR9","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s12883-020-1608-8","volume":"20","author":"A Santaella","year":"2020","unstructured":"Santaella, A. et al. Inflammation biomarker discovery in Parkinson\u2019s disease and atypical parkinsonisms. BMC Neurol. 20(1), 26 (2020).","journal-title":"BMC Neurol."},{"issue":"7","key":"30236_CR10","doi-asserted-by":"publisher","first-page":"e827","DOI":"10.1212\/WNL.0000000000010084","volume":"95","author":"D B\u00e4ckstr\u00f6m","year":"2020","unstructured":"B\u00e4ckstr\u00f6m, D. et al. NfL as a biomarker for neurodegeneration and survival in Parkinson disease. Neurology 95(7), e827\u2013e838 (2020).","journal-title":"Neurology"},{"issue":"2","key":"30236_CR11","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1002\/mds.27888","volume":"35","author":"M Lawton","year":"2020","unstructured":"Lawton, M. et al. Blood biomarkers with Parkinson\u2019s disease clusters and prognosis: The oxford discovery cohort. Movement Disord. 35(2), 279\u2013287 (2020).","journal-title":"Movement Disord."},{"issue":"8","key":"30236_CR12","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1136\/jnnp-2019-322338","volume":"91","author":"J Jankovic","year":"2020","unstructured":"Jankovic, J. & Tan, E. K. Parkinson\u2019s disease: Etiopathogenesis and treatment. J. Neurol. Neurosurg. Psychiatry 91(8), 795\u2013808 (2020).","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"9","key":"30236_CR13","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1002\/mds.20515","volume":"20","author":"S Karamohamed","year":"2005","unstructured":"Karamohamed, S. et al. Absence of previously reported variants in the SCNA (G88C and G209A), NR4A2 (T291D and T245G) and the DJ-1 (T497C) genes in familial Parkinson\u2019s disease from the GenePD study. Movement Disord. 20(9), 1188\u20131191 (2005).","journal-title":"Movement Disord."},{"issue":"2","key":"30236_CR14","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.neulet.2012.03.086","volume":"516","author":"J Tian","year":"2012","unstructured":"Tian, J. et al. Mutation analysis of LRRK2, SCNA, UCHL1, HtrA2 and GIGYF2 genes in Chinese patients with autosomal dorminant Parkinson\u2019s disease. Neurosci. Lett. 516(2), 207\u2013211 (2012).","journal-title":"Neurosci. Lett."},{"issue":"7","key":"30236_CR15","doi-asserted-by":"publisher","first-page":"2220","DOI":"10.1093\/brain\/awaa167","volume":"143","author":"Y Zhao","year":"2020","unstructured":"Zhao, Y. et al. The role of genetics in Parkinson\u2019s disease: A large cohort study in Chinese mainland population. Brain 143(7), 2220\u20132234 (2020).","journal-title":"Brain"},{"issue":"10","key":"30236_CR16","doi-asserted-by":"publisher","first-page":"661","DOI":"10.20344\/amp.11978","volume":"32","author":"V Cabreira","year":"2019","unstructured":"Cabreira, V. & Massano, J. Doen\u00e7a de Parkinson: Revis\u00e3o cl\u00ednica e atualiza\u00e7\u00e3o. Acta Med. Port. 32(10), 661\u2013670 (2019).","journal-title":"Acta Med. Port."},{"issue":"6","key":"30236_CR17","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1001\/jama.2019.22360","volume":"323","author":"MJ Armstrong","year":"2020","unstructured":"Armstrong, M. J. & Okun, M. S. Diagnosis and treatment of Parkinson disease. JAMA 323(6), 548 (2020).","journal-title":"JAMA"},{"issue":"18","key":"30236_CR18","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.1007\/s40265-015-0497-4","volume":"75","author":"A Park","year":"2015","unstructured":"Park, A. & Stacy, M. Disease-modifying drugs in Parkinson\u2019s disease. Drugs 75(18), 2065\u20132071 (2015).","journal-title":"Drugs"},{"issue":"11","key":"30236_CR19","first-page":"669","volume":"55","author":"MR Luquin","year":"2012","unstructured":"Luquin, M. R. et al. Levodopa in the treatment of Parkinson\u2019s disease: Myths and realties. Rev. Neurol. 55(11), 669\u2013688 (2012).","journal-title":"Rev. Neurol."},{"issue":"4","key":"30236_CR20","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1177\/08919887211018269","volume":"34","author":"RT Cleary","year":"2021","unstructured":"Cleary, R. T. & Bucholz, R. Neuromodulation approaches in Parkinson\u2019s disease using deep brain stimulation and transcranial magnetic stimulation. J. Geriatr. Psychiatry Neurol. 34(4), 301\u2013309 (2021).","journal-title":"J. Geriatr. Psychiatry Neurol."},{"issue":"4","key":"30236_CR21","doi-asserted-by":"publisher","first-page":"968","DOI":"10.4103\/0028-3886.266268","volume":"67","author":"N Malek","year":"2019","unstructured":"Malek, N. Deep brain stimulation in Parkinson\u2019s disease. Neurol. India 67(4), 968\u2013978 (2019).","journal-title":"Neurol. India"},{"issue":"11","key":"30236_CR22","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1038\/nrneurol.2017.128","volume":"13","author":"MK Mak","year":"2017","unstructured":"Mak, M. K., Wong-Yu, I. S., Shen, X. & Chung, C. L. Long-term effects of exercise and physical therapy in people with Parkinson disease. Nat. Rev. Neurol. 13(11), 689\u2013703 (2017).","journal-title":"Nat. Rev. Neurol."},{"key":"30236_CR23","doi-asserted-by":"publisher","first-page":"104587","DOI":"10.1016\/j.nbd.2019.104587","volume":"132","author":"D Chatterjee","year":"2019","unstructured":"Chatterjee, D. & Kordower, J. H. Immunotherapy in Parkinson\u2019s disease: Current status and future directions. Neurobiol. Dis. 132, 104587\u2013104587 (2019).","journal-title":"Neurobiol. Dis."},{"issue":"7660","key":"30236_CR24","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1038\/nature22815","volume":"546","author":"D Sulzer","year":"2017","unstructured":"Sulzer, D. et al. T cells from patients with Parkinson\u2019s disease recognize \u03b1-synuclein peptides. Nature 546(7660), 656\u2013661 (2017).","journal-title":"Nature"},{"issue":"5","key":"30236_CR25","doi-asserted-by":"publisher","first-page":"537","DOI":"10.2217\/epi.12.50","volume":"4","author":"XS Shu","year":"2012","unstructured":"Shu, X. S., Li, L. & Tao, Q. Chromatin regulators with tumor suppressor properties and their alterations in human cancers. Epigenomics 4(5), 537\u2013549 (2012).","journal-title":"Epigenomics"},{"issue":"17","key":"30236_CR26","doi-asserted-by":"publisher","first-page":"2083","DOI":"10.1080\/15384101.2020.1796037","volume":"19","author":"V Smits","year":"2020","unstructured":"Smits, V., Alonso-de, V. I. & Warmerdam, D. O. Chromatin regulators and their impact on DNA repair and G2 checkpoint recovery. Cell Cycle 19(17), 2083\u20132093 (2020).","journal-title":"Cell Cycle"},{"issue":"3","key":"30236_CR27","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.nbd.2008.09.010","volume":"32","author":"HC Pieper","year":"2008","unstructured":"Pieper, H. C. et al. Different methylation of the TNF-alpha promoter in cortex and substantia nigra: Implications for selective neuronal vulnerability. Neurobiol. Dis. 32(3), 521\u2013527 (2008).","journal-title":"Neurobiol. Dis."},{"key":"30236_CR28","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s13148-017-0365-z","volume":"9","author":"R Delgado-Morales","year":"2017","unstructured":"Delgado-Morales, R., Agis-Balboa, R. C., Esteller, M. & Berdasco, M. Epigenetic mechanisms during ageing and neurogenesis as novel therapeutic avenues in human brain disorders. Clin. Epigenetics 9, 67 (2017).","journal-title":"Clin. Epigenetics"},{"key":"30236_CR29","doi-asserted-by":"publisher","first-page":"115295","DOI":"10.1016\/j.bcp.2022.115295","volume":"206","author":"L Zhang","year":"2022","unstructured":"Zhang, L., Liu, Y., Lu, Y. & Wang, G. Targeting epigenetics as a promising therapeutic strategy for treatment of neurodegenerative diseases. Biochem. Pharmacol. 206, 115295 (2022).","journal-title":"Biochem. Pharmacol."},{"key":"30236_CR30","doi-asserted-by":"publisher","first-page":"140591","DOI":"10.1016\/j.scitotenv.2020.140591","volume":"744","author":"A Aloizou","year":"2020","unstructured":"Aloizou, A. et al. Parkinson\u2019s disease and pesticides: Are microRNAs the missing link?. Sci. Total Environ. 744, 140591 (2020).","journal-title":"Sci. Total Environ."},{"key":"30236_CR31","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/7854_2021_235","volume":"59","author":"L Bernardino","year":"2022","unstructured":"Bernardino, L. Histamine in the crosstalk between innate immune cells and neurons: Relevance for brain homeostasis and disease. Curr. Top. Behav. Neurosci. 59, 261\u2013288 (2022).","journal-title":"Curr. Top. Behav. Neurosci."},{"issue":"1","key":"30236_CR32","doi-asserted-by":"publisher","first-page":"5163","DOI":"10.1038\/s41467-020-18755-4","volume":"11","author":"V Panagiotakopoulou","year":"2020","unstructured":"Panagiotakopoulou, V. et al. Interferon-\u03b3 signaling synergizes with LRRK2 in neurons and microglia derived from human induced pluripotent stem cells. Nat. Commun. 11(1), 5163 (2020).","journal-title":"Nat. Commun."},{"issue":"4","key":"30236_CR33","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1007\/s11481-020-09909-8","volume":"15","author":"T Ikezu","year":"2020","unstructured":"Ikezu, T. et al. Crohn\u2019s and Parkinson\u2019s disease-associated LRRK2 mutations alter type II interferon responses in human CD14+ blood monocytes ex vivo. J. Neuroimmune Pharmacol. 15(4), 794\u2013800 (2020).","journal-title":"J. Neuroimmune Pharmacol."},{"issue":"1","key":"30236_CR34","doi-asserted-by":"publisher","first-page":"3633","DOI":"10.1038\/ncomms4633","volume":"5","author":"C Cebri\u00e1n","year":"2014","unstructured":"Cebri\u00e1n, C. et al. MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration. Nat. Commun. 5(1), 3633 (2014).","journal-title":"Nat. Commun."},{"issue":"2","key":"30236_CR35","doi-asserted-by":"publisher","first-page":"362","DOI":"10.2174\/1570159X19666210924110144","volume":"20","author":"K Chen","year":"2022","unstructured":"Chen, K. et al. cGAS-STING-mediated IFN-I response in host defense and neuroinflammatory diseases. Curr. Neuropharmacol. 20(2), 362\u2013371 (2022).","journal-title":"Curr. Neuropharmacol."},{"key":"30236_CR36","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.ceb.2015.05.006","volume":"34","author":"A Jamin","year":"2015","unstructured":"Jamin, A. & Wiebe, M. S. Barrier to Autointegration Factor (BANF1): Interwoven roles in nuclear structure, genome integrity, innate immunity, stress responses and progeria. Curr. Opin. Cell Biol. 34, 61\u201368 (2015).","journal-title":"Curr. Opin. Cell Biol."},{"issue":"5","key":"30236_CR37","first-page":"6488","volume":"16","author":"J Li","year":"2018","unstructured":"Li, J. et al. Barrier-to-autointegration factor 1: A novel biomarker for gastric cancer. Oncol. Lett. 16(5), 6488\u20136494 (2018).","journal-title":"Oncol. Lett."},{"issue":"6","key":"30236_CR38","doi-asserted-by":"publisher","first-page":"3294","DOI":"10.1093\/nar\/gkab110","volume":"49","author":"JT Burgess","year":"2021","unstructured":"Burgess, J. T. et al. Barrier-to-autointegration-factor (Banf1) modulates DNA double-strand break repair pathway choice via regulation of DNA-dependent kinase (DNA-PK) activity. Nucleic Acids Res. 49(6), 3294\u20133307 (2021).","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"30236_CR39","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1038\/s41467-018-03781-0","volume":"9","author":"M Yao","year":"2018","unstructured":"Yao, M. et al. PCGF5 is required for neural differentiation of embryonic stem cells. Nat. Communun. 9(1), 1463 (2018).","journal-title":"Nat. Communun."},{"issue":"29","key":"30236_CR40","doi-asserted-by":"publisher","first-page":"45398","DOI":"10.18632\/oncotarget.9982","volume":"7","author":"S Nagel","year":"2016","unstructured":"Nagel, S. et al. Deregulation of polycomb repressor complex 1 modifier AUTS2 in T-cell leukemia. Oncotarget 7(29), 45398\u201345413 (2016).","journal-title":"Oncotarget"},{"issue":"10","key":"30236_CR41","doi-asserted-by":"publisher","first-page":"4809","DOI":"10.7150\/thno.55814","volume":"11","author":"Q Zhou","year":"2021","unstructured":"Zhou, Q. et al. WD repeat domain 5 promotes chemoresistance and Programmed Death-Ligand 1 expression in prostate cancer. Theranostics 11(10), 4809\u20134824 (2021).","journal-title":"Theranostics"},{"issue":"5","key":"30236_CR42","first-page":"3069","volume":"40","author":"R Yao","year":"2018","unstructured":"Yao, R. et al. Lysines 207 and 325 methylation of WDR5 catalyzed by SETD6 promotes breast cancer cell proliferation and migration. Oncol. Rep. 40(5), 3069\u20133077 (2018).","journal-title":"Oncol. Rep."},{"issue":"5","key":"30236_CR43","doi-asserted-by":"publisher","first-page":"1678","DOI":"10.1002\/hep.30947","volume":"71","author":"W Gao","year":"2020","unstructured":"Gao, W. et al. HBx protein contributes to liver carcinogenesis by H3K4me3 modification through stabilizing WD repeat domain 5 protein. Hepatology 71(5), 1678\u20131695 (2020).","journal-title":"Hepatology"},{"key":"30236_CR44","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.mcn.2017.04.013","volume":"82","author":"S Baronchelli","year":"2017","unstructured":"Baronchelli, S. et al. Epigenetic and transcriptional modulation of WDR5, a chromatin remodeling protein, in Huntington\u2019s disease human induced pluripotent stem cell (hiPSC) model. Mol. Cell Neurosci. 82, 46\u201357 (2017).","journal-title":"Mol. Cell Neurosci."},{"key":"30236_CR45","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1002\/art.39563","volume":"68","author":"Y Araki","year":"2015","unstructured":"Araki, Y. et al. Histone methylation and STAT3 differentially regulate IL-6-induced MMP gene activation in rheumatoid arthritis synovial fibroblasts. Arthritis Rheumatol. 68, 1111\u20131123 (2015).","journal-title":"Arthritis Rheumatol."},{"issue":"10","key":"30236_CR46","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1038\/nnano.2017.133","volume":"12","author":"J Yoo","year":"2017","unstructured":"Yoo, J. et al. Electromagnetized gold nanoparticles mediate direct lineage reprogramming into induced dopamine neurons in vivo for Parkinson\u2019s disease therapy. Nat. Nanotechnol. 12(10), 1006\u20131014 (2017).","journal-title":"Nat. Nanotechnol."},{"key":"30236_CR47","doi-asserted-by":"publisher","first-page":"748449","DOI":"10.3389\/fmolb.2021.748449","volume":"8","author":"L Liu","year":"2021","unstructured":"Liu, L., Yang, C. & Candelario-Jalil, E. Role of BET proteins in inflammation and CNS diseases. Front. Mol. Biosci. 8, 748449 (2021).","journal-title":"Front. Mol. Biosci."},{"issue":"2","key":"30236_CR48","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.tranon.2017.01.004","volume":"10","author":"X Dinglin","year":"2017","unstructured":"Dinglin, X. et al. RYBP inhibits progression and metastasis of lung cancer by suppressing EGFR signaling and epithelial-mesenchymal transition. Transl. Oncol. 10(2), 280\u2013287 (2017).","journal-title":"Transl. Oncol."},{"issue":"4","key":"30236_CR49","doi-asserted-by":"publisher","first-page":"2046","DOI":"10.1111\/jcmm.13503","volume":"22","author":"S Zhan","year":"2018","unstructured":"Zhan, S., Wang, T., Ge, W. & Li, J. Multiple roles of Ring 1 andYY 1 binding protein in physiology and disease. J. Cell Mol. Med. 22(4), 2046\u20132054 (2018).","journal-title":"J. Cell Mol. Med."},{"issue":"2","key":"30236_CR50","doi-asserted-by":"publisher","first-page":"e22241","DOI":"10.1002\/jbt.22241","volume":"33","author":"A Tong","year":"2019","unstructured":"Tong, A. et al. Overexpression of RYBP inhibits proliferation, invasion, and chemoresistance to cisplatin in anaplastic thyroid cancer cells via the EGFR pathway. J. Biochem. Mol. Toxicol. 33(2), e22241 (2019).","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"30236_CR51","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.neurobiolaging.2017.11.006","volume":"63","author":"Y Miki","year":"2018","unstructured":"Miki, Y. et al. Alteration of autophagy-related proteins in peripheral blood mononuclear cells of patients with Parkinson\u2019s disease. Neurobiol. Aging 63, 33\u201343 (2018).","journal-title":"Neurobiol. Aging"},{"key":"30236_CR52","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.nbd.2013.11.007","volume":"63","author":"E Mutez","year":"2014","unstructured":"Mutez, E. et al. Involvement of the immune system, endocytosis and EIF2 signaling in both genetically determined and sporadic forms of Parkinson\u2019s disease. Neurobiol. Dis. 63, 165\u2013170 (2014).","journal-title":"Neurobiol. Dis."},{"issue":"19","key":"30236_CR53","doi-asserted-by":"publisher","first-page":"10019","DOI":"10.1093\/nar\/gky679","volume":"46","author":"J Lu","year":"2018","unstructured":"Lu, J. et al. FACER: Comprehensive molecular and functional characterization of epigenetic chromatin regulators. Nucleic Acids Res. 46(19), 10019\u201310033 (2018).","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"30236_CR54","doi-asserted-by":"publisher","first-page":"D587","DOI":"10.1093\/nar\/gkac963","volume":"51","author":"M Kanehisa","year":"2023","unstructured":"Kanehisa, M., Furumichi, M., Sato, Y., Kawashima, M. & Ishiguro-Watanabe, M. KEGG for taxonomy-based analysis of pathways and genomes. Nucleic Acids Res. 51(D1), D587\u2013D592 (2023).","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"30236_CR55","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa, M. & Goto, S. KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28(1), 27\u201330 (2000).","journal-title":"Nucleic Acids Res."},{"issue":"11","key":"30236_CR56","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1002\/pro.3715","volume":"28","author":"M Kanehisa","year":"2019","unstructured":"Kanehisa, M. Toward understanding the origin and evolution of cellular organisms. Protein Sci. 28(11), 1947\u20131951 (2019).","journal-title":"Protein Sci."},{"issue":"11","key":"30236_CR57","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon, P. et al. Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13(11), 2498\u20132504 (2003).","journal-title":"Genome Res."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-023-30236-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-023-30236-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-023-30236-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T07:03:28Z","timestamp":1701932608000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-023-30236-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,22]]},"references-count":57,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["30236"],"URL":"https:\/\/doi.org\/10.1038\/s41598-023-30236-4","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,22]]},"assertion":[{"value":"13 July 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 February 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 February 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"3084"}}