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This study included 639 patients treated between January 2019 and February 2022. The patients were divided into low- and high-difference groups based on the median value of the difference between the Cr-based eGFR (eGFR<jats:sub>Cr<\/jats:sub>) and CysC-based eGFR (eGFR<jats:sub>CysC<\/jats:sub>). Sociodemographic and laboratory factors underlying a high difference between eGFR<jats:sub>Cr<\/jats:sub> and eGFR<jats:sub>CysC<\/jats:sub> were analyzed. The association intensity of eGFR<jats:sub>Cr<\/jats:sub>, eGFR<jats:sub>CysC<\/jats:sub> and both Cr- and CysC-based eGFR (eGFR<jats:sub>Cr-CysC<\/jats:sub>) was compared using the area under the receiver operating characteristic curve (AuROC) values for hyperphosphatemia and hyperparathyroidism occurrence in the overall cohort and the low- and high-difference groups. Age\u2009&gt;\u200970\u00a0years and CKD grade 3 based on eGFR<jats:sub>Cr<\/jats:sub> were significant factors affecting the high differences. eGFR<jats:sub>CysC<\/jats:sub> and eGFR<jats:sub>Cr-CysC<\/jats:sub> showed higher AuROC values than that of eGFR<jats:sub>Cr<\/jats:sub>, especially in the high-difference group and in patients with CKD grade 3. Our results show that CysC should be evaluated in patients with significant factors, including age\u2009&gt;\u200970\u00a0years and CKD grade 3, to accurately assess kidney function to better determine the physiological changes in CKD progression and predict prognosis accurately.\n<\/jats:p>","DOI":"10.1038\/s41598-023-31048-2","type":"journal-article","created":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T19:30:29Z","timestamp":1679859029000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Comparison of the association intensity of creatinine and cystatin C with hyperphosphatemia and hyperparathyroidism in patients with chronic kidney disease"],"prefix":"10.1038","volume":"13","author":[{"given":"Byungju","family":"Min","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Ro","family":"Yun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se-Hee","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Dai","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan Jin","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Min","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohan","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,8]]},"reference":[{"key":"31048_CR1","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/ki.2013.444","volume":"85","author":"A Levin","year":"2014","unstructured":"Levin, A. & Stevens, P. 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