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This study included 123 shoulder joints of 119 patients, which were scanned in 3.0\u00a0T MRI with axial Fat Suppression Proton Density Weighted Image (FS-PDWI), sagittal fat suppression T2 Weighted Image (FS-T2WI), coronal T1Weighted Image (T1WI), FS-PDWI, cartilage-specific T1, T2 and T2* mapping sequences. Basing on MRI images, the shoulder cartilage was classified into grades 0 1, 2, 3 and 4 according to the International Cartilage Regeneration &amp; Joint Preservation Society (ICRS). The grading of shoulder cartilage was based on MRI images with ICRS as reference, and did not involve arthroscopy or histology.The T1, T2 and T2* relaxation values in the superior, middle and inferior bands of shoulder articular cartilage were measured at all grades, and the differences in various indicators between groups were analyzed and compared using a single-factor ANOVA test. The correlation between T1, T2 and T2* relaxation values and MRI-based grading was analyzed by SPSS software. There were 46 shoulder joints with MRI-based grade 0 in healthy control group (n\u2009=\u200946), while 49 and 28 shoulder joints with grade 1\u20132 (mild degeneration subgroup) and grade 3\u20134 (severe degeneration subgroup) in patient group (n\u2009=\u200973), accounting for 63.6% and 36.4%, respectively. The T1, T2 and T2* relaxation values of the superior, middle and inferior bands of shoulder articular cartilage were significantly and positively correlated with the MRI-based grading (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). MRI-basedgrading of shoulder cartilage was markedly associated with age (r\u2009=\u20090.766, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). With the aggravation of cartilage degeneration, T1, T2 and T2* relaxation values showed an upward trend (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), and T1, T2 and T2* mapping could distinguish cartilage degeneration at all levels (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). The T1, T2 and T2* relaxation values were significantly different between normal group and mild degeneration subgroup, normal group and severe degeneration subgroup, mild degeneration subgroup and severe degeneration subgroup (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Quantitative T1, T2 and T2* mapping can quantify the degree of shoulder cartilage degeneration. All these MRI mapping quantification techniques can be used as critical supplementary sequences to assess shoulder cartilage degeneration, among which T2 mapping has the highest value.<\/jats:p>","DOI":"10.1038\/s41598-023-31644-2","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T13:03:57Z","timestamp":1679317437000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Application of quantitative T1, T2 and T2* mapping magnetic resonance imaging in cartilage degeneration of the shoulder joint"],"prefix":"10.1038","volume":"13","author":[{"given":"Guijuan","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubo","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,20]]},"reference":[{"key":"31644_CR1","first-page":"28","volume":"70","author":"LS Lohmander","year":"2004","unstructured":"Lohmander, L. 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