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We assessed the impact of iron dextran on reticulocyte (Ret) Hb equivalent (Ret-He) and Ret subpopulations in iron-deficient sepsis patients. In this prospective clinical study we enrolled patients with sepsis or septic shock with procalcitonin concentration\u2009&gt;\u20090.5\u00a0ng\/mL, diagnosed with ID based on Ret-He. Study subjects received divided doses of iron dextran until normalization of Ret-He. The study population included 35 subjects. The median Ret-He increase after 2 doses of iron dextran was 3.0 (IQR 1.9\u20136.1) pg (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) with median time to normalization 4 (IQR 3\u20135) days. Although no change in Ret percentage [Me 1.5 (IQR 1.1\u20132.1) vs. Me 1.4 (IQR 1.1\u20132.4) %, <jats:italic>p<\/jats:italic>\u2009=\u20090.39] and number [Me 0.05 (IQR 0.04\u20130.07) vs. Me 0.05 (IQR 0.03\u20130.06) 10<jats:sup>6<\/jats:sup>\/\u00b5L, <jats:italic>p<\/jats:italic>\u2009=\u20090.88] was noted, Ret subpopulations changed significantly (<jats:italic>p<\/jats:italic> for all\u2009&lt;\u20090.01). Divided doses of iron dextran relatively quickly normalize Ret-He in iron-deficient sepsis patients. Changes in Ret subpopulations suggest increased erythropoietic activity. Further research is needed to explore the role of intravenous iron in this clinical setting.<\/jats:p>","DOI":"10.1038\/s41598-023-32002-y","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T10:02:54Z","timestamp":1680256974000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Iron deficiency in sepsis patients managed with divided doses of iron dextran: a prospective cohort study"],"prefix":"10.1038","volume":"13","author":[{"given":"Piotr F.","family":"Czempik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Wi\u00f3rek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,31]]},"reference":[{"key":"32002_CR1","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1182\/blood-2013-06-508325","volume":"123","author":"NJ Kassebaum","year":"2014","unstructured":"Kassebaum, N. 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