{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:19:23Z","timestamp":1767705563947,"version":"3.37.3"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T00:00:00Z","timestamp":1682640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T00:00:00Z","timestamp":1682640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Measurements of transepithelial potential and resistance in tissue and organ model systems enable the evaluation of the Ni<jats:sup>2+<\/jats:sup> effect on the epithelial sodium channels, aquaporin 3, and the sodium\u2013potassium pump in the epithelial cells. The aim of the presented study was to assess the immediate and prolonged effect of nickel ions on the transport of sodium ions in tissues exposed to direct contact with nickel, including airways, digestive tract and the skin. The influence of 0.1\u00a0mM nickel solution was performed on the trachea (n\u2009=\u200934), intestine (n\u2009=\u200944), and skin (n\u2009=\u200951) samples descended from 16 New Zealand albino rabbits. The electrophysiological parameters were measured in a modified Ussing chamber in stationary conditions and during a 15-s mechanical-chemical stimulation. A statistically significant decrease in the electric resistance values and the smallest range of the measured potential were observed for the Ni-treated trachea specimens. The use of nickel solution did not affect the sodium transport in the intestine epithelium. The skin fragments showed altered sodium ion transport, as demonstrated by the lower range and intensity of the measured potential. The gastrointestinal tract seems to be an organ best adapted to contact with nickel ions. In airways, nickel ions most likely enter epithelial cells and the space between them, modifying proteins and the airway surface liquid. The skin turned out to be the most sensitive tissue to the intensification of sodium ion transport through nickel ions.<\/jats:p>","DOI":"10.1038\/s41598-023-33690-2","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T10:04:45Z","timestamp":1682676285000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Nickel ions influence the transepithelial sodium transport in the trachea, intestine and skin"],"prefix":"10.1038","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0986-5604","authenticated-orcid":false,"given":"Iga","family":"Ho\u0142y\u0144ska-Iwan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Sobiesiak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech","family":"Kowalczyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcin","family":"Wr\u00f3blewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Cwynar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolina","family":"Szewczyk-Golec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,4,28]]},"reference":[{"key":"33690_CR1","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1080\/00958972.2012.751488","volume":"66","author":"R Prabu","year":"2013","unstructured":"Prabu, R. et al. Synthesis, characterization, catalytic, and biological studies of macrobicyclic binuclear nickel(II) complexes of 1,8-difunctionalized cyclam derivatives. J. Coord. Chem. 66, 206\u2013217 (2013).","journal-title":"J. Coord. Chem."},{"key":"33690_CR2","doi-asserted-by":"publisher","first-page":"e5423","DOI":"10.1002\/aoc.5423","volume":"34","author":"G Balan","year":"2019","unstructured":"Balan, G. et al. Novel 2-formylpyridine 4-allyl-S-methylisothiosemicarbazone and Zn(II), Cu(II), Ni(II) and Co(III) complexes: Synthesis, characterization, crystal structure, antioxidant, antimicrobial and antiproliferative activity. Appl. Organomet. Chem. 34, e5423. https:\/\/doi.org\/10.1002\/aoc.5423 (2019).","journal-title":"Appl. Organomet. Chem."},{"key":"33690_CR3","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.4314\/jasem.v20i4.32","volume":"20","author":"HF Babamale","year":"2016","unstructured":"Babamale, H. F., Lawal, A., Rajee, O. A. & Oloyede, E. A. synthesis, characterization and biological activity studies of mixed paracetamol-ascorbic acid metal complexes. J. Appl. Sci. Environ. Manag. 20, 1157\u20131161. https:\/\/doi.org\/10.4314\/jasem.v20i4.32 (2016).","journal-title":"J. Appl. Sci. Environ. Manag."},{"key":"33690_CR4","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/S0020-1693(01)00375-9","volume":"315","author":"P Bombicz","year":"2001","unstructured":"Bombicz, P., Forizs, E., Madarasz, J., Deak, A. & Kalman, A. Inclusion compounds containing a drug: Structure and thermal stability of the first clathrates of nitrazepam and isothiocyanato ethanol complexes of Co(II) and Ni(II). Inorg. Chim. Acta 315, 229\u2013235 (2001).","journal-title":"Inorg. Chim. Acta"},{"key":"33690_CR5","doi-asserted-by":"publisher","first-page":"9126","DOI":"10.1039\/C8NJ01033A","volume":"42","author":"K Das","year":"2018","unstructured":"Das, K. et al. EPR and electrochemical interpretation of bispyrazolylacetate anchored Ni(ii) and Mn(ii) complexes: Cytotoxicity and anti-proliferative activity towards human cancer cell lines. New J. Chem. 42, 9126\u20139139 (2018).","journal-title":"New J. Chem."},{"key":"33690_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10534-012-9589-8","volume":"26","author":"C Hsu","year":"2013","unstructured":"Hsu, C., Kuo, C., Chuang, S. & Hou, M. Elucidation of the DNA-interacting properties and anticancer activity of a Ni(II)-coordinated mithramycin dimer complex. Biometals 26, 1\u201312. https:\/\/doi.org\/10.1007\/s10534-012-9589-8 (2013).","journal-title":"Biometals"},{"key":"33690_CR7","doi-asserted-by":"publisher","first-page":"15950","DOI":"10.1039\/C4DT02366H","volume":"43","author":"AM Mansour","year":"2014","unstructured":"Mansour, A. M. Crystal structure, DFT, spectroscopic and biological activity evaluation of analgin complexes with Co (II), Ni (II) and Cu (II). Dalton Trans. 43, 15950\u201315957. https:\/\/doi.org\/10.1039\/C4DT02366H (2014).","journal-title":"Dalton Trans."},{"key":"33690_CR8","doi-asserted-by":"publisher","first-page":"2229","DOI":"10.1016\/j.poly.2006.01.018","volume":"25","author":"G Morgant","year":"2006","unstructured":"Morgant, G., Bouhmaida, N., Balde, L., Ghermani, N. E. & d\u2019Angelo, J. Low-temperature (100 K) crystal structures of pentaaqua(5-nitrosalicylato) complexes of magnesium(II), zinc(II), cobalt(II) and nickel(II): A \u03c0\u2013\u03c0 stacked and hydrogen bonded 3D supramolecular architecture. Polyhedron 25, 2229\u20132235 (2006).","journal-title":"Polyhedron"},{"key":"33690_CR9","doi-asserted-by":"publisher","first-page":"45","DOI":"10.4236\/ojinm.2020.104004","volume":"10","author":"FSM Hassan","year":"2020","unstructured":"Hassan, F. S. M., Fayez, M. & Abdalla, N. Synthesis, characterization, antibacterial, and antifungal activities of cobalt(II), nickel(II) and copper(II) complexes with 3-thioacetyl-2-amino-1,4-naphthoquinone and 2-benzoyl-3-amino-1,4-naphthoquinone ligands. OJINM 10, 45\u201361. https:\/\/doi.org\/10.4236\/ojinm.2020.104004 (2020).","journal-title":"OJINM"},{"key":"33690_CR10","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.poly.2012.11.031","volume":"50","author":"DC Saswati-Rupam","year":"2013","unstructured":"Saswati-Rupam, D. C. et al. Mixed-ligand nickel(II) thiosemicarbazone complexes: Synthesis, characterization and biological evaluation. Polyhedron 50, 354\u2013363. https:\/\/doi.org\/10.1016\/j.poly.2012.11.031 (2013).","journal-title":"Polyhedron"},{"key":"33690_CR11","first-page":"1","volume":"20156366","author":"SH Sumrra","year":"2016","unstructured":"Sumrra, S. H. et al. Metal based drugs: Design, synthesis and in-vitro antimicrobial screening of Co(II), Ni(II), Cu(II) and Zn(II) complexes with some new carboxamide derived compounds: Crystal structures of N-[ethyl (propan-2-yl) carbamothioyl] thiophene-2-carboxamide and its copper(II) complex. J. Enzyme Inhib. Med. Chem. 20156366, 1\u20139 (2016).","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"33690_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jinorgbio.2012.02.025","volume":"112","author":"I Ramirez-Macias","year":"2012","unstructured":"Ramirez-Macias, I. et al. In vitro anti-leishmania evaluation of nickel complexes with a triazolopyrimidine derivative against Leishmania infantum and Leishmania braziliensis. J. Inorg. Biochem. 112, 1\u20139 (2012).","journal-title":"J. Inorg. Biochem."},{"key":"33690_CR13","doi-asserted-by":"publisher","first-page":"e100933","DOI":"10.1371\/journal.pone.0100933","volume":"9","author":"HB Shawish","year":"2014","unstructured":"Shawish, H. B. et al. Nickel (II) complex of polyhydroxybenzaldehyde N4-thiosemicarbazone exhibits anti-inflammatory activity by inhibiting NF-jB transactivation. PLoS ONE 9, e100933. https:\/\/doi.org\/10.1371\/journal.pone.0100933 (2014).","journal-title":"PLoS ONE"},{"key":"33690_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00775-016-1424-1","volume":"22","author":"J Haribabu","year":"2017","unstructured":"Haribabu, J. et al. Synthesis of Ni(II) complexes bearing indolebased thiosemicarbazone ligands for interaction with biomolecules and some biological applications. J. Biol. Inorg. Chem. 22, 1\u201320 (2017).","journal-title":"J. Biol. Inorg. Chem."},{"key":"33690_CR15","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.jinorgbio","volume":"162","author":"S Perontsis","year":"2016","unstructured":"Perontsis, S., Hatzidimitriou, A. G., Papadopoulos, A. N. & Psomas, G. Nickel-diflunisal complexes: Synthesis, characterization, in vitro antioxidant activity and interaction with DNA and albumins. J. Inorg. Biochem. 162, 9\u201321. https:\/\/doi.org\/10.1016\/j.jinorgbio (2016).","journal-title":"J. Inorg. Biochem."},{"key":"33690_CR16","doi-asserted-by":"publisher","first-page":"111198","DOI":"10.1016\/j.jinorgbio.2020.111198","volume":"211","author":"N Munoz-Patino","year":"2020","unstructured":"Munoz-Patino, N. et al. Synthesis, structure, and biological activity of bis(benzimidazole)amino thio- and selenoether nickel complexes. J. Inorg. Biochem. 211, 111198. https:\/\/doi.org\/10.1016\/j.jinorgbio.2020.111198 (2020).","journal-title":"J. Inorg. Biochem."},{"key":"33690_CR17","doi-asserted-by":"publisher","first-page":"679","DOI":"10.3390\/ijerph17030679","volume":"17","author":"G Genchi","year":"2020","unstructured":"Genchi, G., Carocci, A., Lauria, G., Sinicropi, M. S. & Catalano, A. Nickel: Human health and environmental toxicology. Int. J. Environ. Res. Public Health. 17, 679. https:\/\/doi.org\/10.3390\/ijerph17030679 (2020).","journal-title":"Int. J. Environ. Res. Public Health."},{"key":"33690_CR18","doi-asserted-by":"publisher","first-page":"103","DOI":"10.3390\/nu9020103","volume":"9","author":"A D\u2019Alcamo","year":"2017","unstructured":"D\u2019Alcamo, A. et al. Contact dermatitis due to nickel allergy in patients suffering from non-celiac wheat sensitivity. Nutrients 9, 103 (2017).","journal-title":"Nutrients"},{"key":"33690_CR19","doi-asserted-by":"publisher","first-page":"202","DOI":"10.3390\/ijms17020202","volume":"17","author":"S Masako","year":"2016","unstructured":"Masako, S. et al. Molecular mechanisms of nickel allergy. Int. J. Mol. Sci. 17, 202 (2016).","journal-title":"Int. J. Mol. Sci."},{"key":"33690_CR20","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1080\/08958378.2017.1406563","volume":"29","author":"D Sah","year":"2017","unstructured":"Sah, D., Verma, P. K., Kumari, K. M. & Lakhani, A. Chemical partitioning of fine particle-bound As, Cd, Cr, Ni Co, Pb and assessment of associated cancer risk due to inhalation, ingestion and dermal exposure. Inhal. Toxicol. 29, 483\u2013493. https:\/\/doi.org\/10.1080\/08958378.2017.1406563 (2017).","journal-title":"Inhal. Toxicol."},{"key":"33690_CR21","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/j.jinorgbio.2009.01.006","volume":"103","author":"G Barone","year":"2009","unstructured":"Barone, G. et al. Spectroscopic study of the interaction of Ni-II-5-triethyl ammonium methyl salicylidene ortho-phenylendiiminate with native DNA. J. Inorg. Biochem. 103, 731\u2013737. https:\/\/doi.org\/10.1016\/j.jinorgbio.2009.01.006 (2009).","journal-title":"J. Inorg. Biochem."},{"key":"33690_CR22","doi-asserted-by":"publisher","first-page":"18094","DOI":"10.1038\/s41598-020-75275-3","volume":"10","author":"I Ho\u0142y\u0144ska-Iwan","year":"2020","unstructured":"Ho\u0142y\u0144ska-Iwan, I. & Szewczyk-Golec, K. Analysis of changes in sodium and chloride ion transport in the skin. Sci. Rep. 10, 18094. https:\/\/doi.org\/10.1038\/s41598-020-75275-3 (2020).","journal-title":"Sci. Rep."},{"key":"33690_CR23","doi-asserted-by":"publisher","first-page":"112939","DOI":"10.1016\/j.biopha.2022.112939","volume":"150","author":"A Gryn-Rynko","year":"2022","unstructured":"Gryn-Rynko, A. et al. The impact of Morus alba L. leaf extract on intestinal ion transport. An in vitro study. Bomed. Pharmacother. 150, 112939. https:\/\/doi.org\/10.1016\/j.biopha.2022.112939 (2022).","journal-title":"Bomed. Pharmacother."},{"key":"33690_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biopha.2020.110502","volume":"129","author":"I Ho\u0142y\u0144ska-Iwan","year":"2020","unstructured":"Ho\u0142y\u0144ska-Iwan, I. & Sobiesiak, M. Cisplatin influences the skin ion transport: An in vitro study. Biomed. Pharmacol. 129, 1\u201311. https:\/\/doi.org\/10.1016\/j.biopha.2020.110502 (2020).","journal-title":"Biomed. Pharmacol."},{"key":"33690_CR25","doi-asserted-by":"publisher","first-page":"362","DOI":"10.5604\/01.3001.0014.3831","volume":"74","author":"I Ho\u0142y\u0144ska-Iwan","year":"2020","unstructured":"Ho\u0142y\u0144ska-Iwan, I., Dziembowska, I. & Olszewska-S\u0142onina, D. The short-term rinsing of airways by N-acetylcysteine helps expectoration: The mechanism of sodium and chloride transport. Postepy Hig. Med. Dosw. 74, 362\u2013370. https:\/\/doi.org\/10.5604\/01.3001.0014.3831 (2020).","journal-title":"Postepy Hig. Med. Dosw."},{"key":"33690_CR26","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1038\/jid.2014.477","volume":"135","author":"W Xu","year":"2015","unstructured":"Xu, W. et al. Hydration status regulates sodium flux and inflammatory pathways through epithelial sodium channel (ENaC) in the skin. J. Invest Dermatol. 135, 796\u2013806. https:\/\/doi.org\/10.1038\/jid.2014.477 (2015).","journal-title":"J. Invest Dermatol."},{"key":"33690_CR27","doi-asserted-by":"publisher","first-page":"312ra177","DOI":"10.1126\/scitranslmed.aad0286","volume":"7","author":"W Xu","year":"2015","unstructured":"Xu, W. et al. Sodium channel Nax is a regulator in epithelial sodium homeostasis. Sci. Transl. Med. 7, 312ra177. https:\/\/doi.org\/10.1126\/scitranslmed.aad0286 (2015).","journal-title":"Sci. Transl. Med."},{"key":"33690_CR28","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1111\/j.1600-0846.2007.00217.x","volume":"13","author":"D Ferreira","year":"2007","unstructured":"Ferreira, D., Silva, C. & Souza, M. Electrical impedance model for evaluation of skin irritation in rabbits and humans. Skin Res. Technol. 13, 259\u2013267 (2007).","journal-title":"Skin Res. Technol."},{"key":"33690_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/jat.3004","volume":"35","author":"EC Jung","year":"2015","unstructured":"Jung, E. C. & Maibach, H. Animal models for percutaneous absorption. J. Appl. Toxicol. 35, 1\u201310 (2015).","journal-title":"J. Appl. Toxicol."},{"key":"33690_CR30","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.chemosphere.2015.11.076","volume":"145","author":"M Croscera","year":"2016","unstructured":"Croscera, M. et al. In vitro dermal penetration of nickel nanoparticles. Chemosphere 145, 301\u2013306. https:\/\/doi.org\/10.1016\/j.chemosphere.2015.11.076 (2016).","journal-title":"Chemosphere"},{"key":"33690_CR31","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3181\/00379727-191-42881","volume":"191","author":"FW Sunderman","year":"1989","unstructured":"Sunderman, F. W. et al. Nickel absorption and kinetics in human volunteers. Proc. Soc. Exp. Biol. Med. 191, 5\u201311. https:\/\/doi.org\/10.3181\/00379727-191-42881 (1989).","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"33690_CR32","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1002\/iid3.274","volume":"7","author":"Y Kageyama","year":"2019","unstructured":"Kageyama, Y. et al. Higher incidence of zinc and nickel hypersensitivity in patients with irritable bowel syndrome. Immun. Inflamm. Dis. 7, 304\u2013307. https:\/\/doi.org\/10.1002\/iid3.274 (2019).","journal-title":"Immun. Inflamm. Dis."},{"key":"33690_CR33","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1080\/000155501753279578","volume":"212","author":"J Host\u00fdnek","year":"2001","unstructured":"Host\u00fdnek, J., Dreher, F., Pelosi, A., Angibogu, A. & Maibach, H. Human stratum corneum penetration by nickel in vivo study of depth distribution after occlusive application of the metal as powder. Acta Derm. Venereol. Suppl. 212, 5\u201310 (2001).","journal-title":"Acta Derm. Venereol. Suppl."},{"key":"33690_CR34","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1111\/cod.13136","volume":"80","author":"MG Ahlstr\u00f6m","year":"2019","unstructured":"Ahlstr\u00f6m, M. G. et al. Nickel deposition and penetration into the stratum corneum after short metallic nickel contact: An experimental study. Contact Dermat. 80, 86\u201393 (2019).","journal-title":"Contact Dermat."},{"key":"33690_CR35","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1111\/bjd.16935","volume":"179","author":"MG Ahlstr\u00f6m","year":"2018","unstructured":"Ahlstr\u00f6m, M. G. et al. Short contact with nickel causes allergic contact dermatitis: An experimental study. Br. J. Dermatol. 179, 1127\u20131134 (2018).","journal-title":"Br. J. Dermatol."},{"key":"33690_CR36","doi-asserted-by":"publisher","first-page":"101","DOI":"10.5056\/jnm16027","volume":"23","author":"A Rizzi","year":"2017","unstructured":"Rizzi, A. et al. Irritable bowel syndrome and nickel allergy: What the role of the low nickel diet?. J. Neurogastroenterol. Motil. 23, 101\u2013108. https:\/\/doi.org\/10.5056\/jnm16027 (2017).","journal-title":"J. Neurogastroenterol. Motil."},{"key":"33690_CR37","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1034\/j.1600-0773.2003.920303.x","volume":"92","author":"J Tallkvist","year":"2003","unstructured":"Tallkvist, J., Bowlus, C. & L\u00f6nnerdal, B. Effect of iron treatment on nickel absorption and gene expression of the divalent metal transporter (DMT1) by human intestinal Caco-2 cells. Pharmacol. Toxicol. 92, 121\u2013124. https:\/\/doi.org\/10.1034\/j.1600-0773.2003.920303.x (2003).","journal-title":"Pharmacol. Toxicol."},{"key":"33690_CR38","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s00232-003-2023-y","volume":"194","author":"D Cucu","year":"2003","unstructured":"Cucu, D., Simaels, J., Van Driessche, W. & Zeiske, W. External Ni2+ and ENaC in A6 cells: Na+ current stimulation by competition at a binding site for amiloride and Na+. J. Membr. Biol. 194, 33\u201345 (2003).","journal-title":"J. Membr. Biol."},{"key":"33690_CR39","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1152\/ajpcell.00419.2004","volume":"289","author":"D Cucu","year":"2005","unstructured":"Cucu, D., Simaels, J., Eggermont, J., Driessche, W. V. & Zeiske, W. Opposite effects of Ni2+ on Xenopus and rat ENaCs expressed in Xenopus oocytes. Am. J. Physiol. Cell Physiol. 289, 946\u2013958 (2005).","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"33690_CR40","doi-asserted-by":"publisher","first-page":"30037","DOI":"10.1074\/jbc.M302206200","volume":"278","author":"M Zelenina","year":"2003","unstructured":"Zelenina, M., Bondar, A., Zelenin, S. & Aperia, A. Nickel and extracellular acidification inhibit the water permeability of human aquaporin-3 in lung epithelial cells. J. Biol. Chem. 278, 30037\u201330043. https:\/\/doi.org\/10.1074\/jbc.M302206200 (2003).","journal-title":"J. Biol. Chem."},{"key":"33690_CR41","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.tiv.2010.11.013","volume":"25","author":"E Forti","year":"2011","unstructured":"Forti, E. et al. In vitro evaluation of the toxicity induced by nickel soluble and particulate forms in human airway epithelial cells. Toxicol. In Vitro 25, 454\u2013461 (2011).","journal-title":"Toxicol. In Vitro"},{"key":"33690_CR42","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1111\/cod.12846","volume":"77","author":"MG Ahlstr\u00f6m","year":"2017","unstructured":"Ahlstr\u00f6m, M. G., Thyssen, J. P., Menn\u00e9, T. & Johansen, J. D. Prevalence of nickel allergy in Europe following the EU Nickel Directive: A review. Contact Dermat. 77, 193\u2013200. https:\/\/doi.org\/10.1111\/cod.12846 (2017).","journal-title":"Contact Dermat."},{"key":"33690_CR43","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1177\/0748233717738633","volume":"34","author":"W Mai","year":"2018","unstructured":"Mai, W., Lu, D., Liu, X. & Chen, L. MCP-1 produced by keratinocytes is associated with leucocyte recruitment during elicitation of nickel-induced occupational allergic contact dermatitis. Toxicol. Ind. Health 34, 36\u201343. https:\/\/doi.org\/10.1177\/0748233717738633 (2018).","journal-title":"Toxicol. Ind. Health"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-023-33690-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-023-33690-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-023-33690-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T10:22:06Z","timestamp":1682677326000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-023-33690-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,28]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["33690"],"URL":"https:\/\/doi.org\/10.1038\/s41598-023-33690-2","relation":{},"ISSN":["2045-2322"],"issn-type":[{"type":"electronic","value":"2045-2322"}],"subject":[],"published":{"date-parts":[[2023,4,28]]},"assertion":[{"value":"8 November 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"6931"}}