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We evaluated resting-state FC between eight ARAS nuclei and 105 cortical\/subcortical regions in OSA patients and healthy controls. Fifty patients with moderate to severe OSA and 20 controls underwent overnight polysomnography and resting-state functional magnetic resonance imaging. Seed-to-voxel analysis of ARAS\u2013cortex FC was compared between OSA patients and controls. The ARAS nuclei included the locus coeruleus (LC), laterodorsal tegmental nucleus (LDTg), and ventral tegmental area (VTA). FC values of three ARAS nuclei (the LC, LDTg, and VTA) significantly differed between the groups. FC of the LC with the precuneus, posterior cingulate gyrus, and right lateral occipital cortex (LOC) was stronger in OSA patients than controls. FC between the LDTg and right LOC was stronger in OSA patients than controls, but FC between the VTA and right LOC was weaker. Average LC\u2013cortex FC values positively correlated with the arousal, apnea, and apnea\u2013hypopnea index in OSA patients. Alterations in ARAS\u2013cortex FC were observed in OSA patients. The strength of LC\u2013cortex noradrenergic FC was related to arousal or OSA severity in patients.<\/jats:p>","DOI":"10.1038\/s41598-023-35535-4","type":"journal-article","created":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T05:04:41Z","timestamp":1685423081000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Altered functional connectivity of the ascending reticular activating system in obstructive sleep apnea"],"prefix":"10.1038","volume":"13","author":[{"given":"Jung-Ick","family":"Byun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geon-Ho","family":"Jahng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Woo","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soonchan","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun Hee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Ok","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki-Young","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Chul","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,5,30]]},"reference":[{"issue":"116","key":"35535_CR1","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1152\/japplphysiol.00649.2013","volume":"1985","author":"DJ Eckert","year":"2014","unstructured":"Eckert, D. 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