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This study aimed to develop \u2018myopia progression risk assessment score\u2019 (MPRAS) based on multiple risk factors (10) to determine whether a myope is \u201cat-risk\u201d or \u201clow-risk\u201d for myopia progression. Two risk-score models (model-1: non-weightage, model-2: weightage) were developed. Ability of MPRAS to diagnose individual \u201cat-risk\u201d for myopia progression was compared against decision of five clinicians in 149 myopes, aged 6\u201329\u00a0years. Using model-1 (no-weightage), further 7 sub-models were created with varying number of risk factors in decreasing step-wise manner (1a: 10 factors to 1g: 4 factors). In random eye analysis for model-1, the highest Youden\u2019s J-index (0.63\u20130.65) led to the MPRAS cut-off score of 41.50\u201343.50 for 5 clinicians with a sensitivity ranging from 78 to 85% and specificity ranging from 79 to 87%. For this cut-off score, the mean area under the curve (AUC) between clinicians and the MPRAS model ranged from 0.89 to 0.90. Model-2 (weighted for few risk-factors) provided similar sensitivity, specificity, and AUC. Sub-model analysis revealed greater AUC with high sensitivity (89%) and specificity (94%) in model-1g that has 4 risk factors compared to other sub-models (1a\u20131f). All the MPRAS models showed good agreement with the clinician\u2019s decision in identifying individuals \u201cat-risk\u201d for myopia progression.<\/jats:p>","DOI":"10.1038\/s41598-023-35696-2","type":"journal-article","created":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T12:04:45Z","timestamp":1685534685000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Myopia progression risk assessment score (MPRAS): a promising new tool for risk stratification"],"prefix":"10.1038","volume":"13","author":[{"given":"Manoj K.","family":"Manoharan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swapnil","family":"Thakur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Dhakal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish K.","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacinth J.","family":"Priscilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashank K.","family":"Bhandary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alok","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivas","family":"Marmamula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitish","family":"Poigal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavan K.","family":"Verkicharla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,5,31]]},"reference":[{"key":"35696_CR1","doi-asserted-by":"publisher","first-page":"e339","DOI":"10.1016\/S2214-109X(13)70113-X","volume":"1","author":"RR Bourne","year":"2013","unstructured":"Bourne, R. 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