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This study aimed at isolation and identification of\n                    <jats:italic>M. haemolytica<\/jats:italic>\n                    and\n                    <jats:italic>P. multocida<\/jats:italic>\n                    associated with pneumonic pasteurellosis in sheep and goats using bacteriological and molecular techniques. Identification of serotypes of\n                    <jats:italic>M. haemolytica<\/jats:italic>\n                    and\n                    <jats:italic>P. multocida<\/jats:italic>\n                    was done using indirect haemagglutination test. The in vitro antimicrobial sensitivity profiles of the\n                    <jats:italic>M. haemolytica<\/jats:italic>\n                    were tested using standard disk diffusion method. A total of 52 and 78 nasal swabs were collected from pneumonic cases for bacterial isolation and identification in Borana and Arsi zone, respectively. Four hundred sera samples were collected for identification of serotypes. The results showed that 17 of 52 (32.69%; 95% CI 20.33, 47.11) nasal swabs collected from pneumonic animals in Borana yielded positive results for\n                    <jats:italic>Pasteurella<\/jats:italic>\n                    \/\n                    <jats:italic>Mannheimia<\/jats:italic>\n                    species, 13 (25.00%; 95% CI 14.03, 38.95) of which were\n                    <jats:italic>M. haemolytica<\/jats:italic>\n                    . None of the samples yielded\n                    <jats:italic>P. multocida<\/jats:italic>\n                    . Twenty-three of 78 (29.49%; 95% CI 19.69, 40.89) nasal swabs collected at Arsi from pneumonic animals yielded positive results for\n                    <jats:italic>M. haemolytica<\/jats:italic>\n                    (17) and\n                    <jats:italic>P. multocida<\/jats:italic>\n                    (6). Secondary biochemical characterization revealed that 14 of the 17 isolates conform to\n                    <jats:italic>M. haemolytica<\/jats:italic>\n                    whereas none of the 6 isolates suspected to be\n                    <jats:italic>P. mutocida<\/jats:italic>\n                    were confirmed. Eleven (84.62%) isolates from Borana and 4 (28.57%) from Arsi were confirmed to be\n                    <jats:italic>M. haemolytica<\/jats:italic>\n                    using PCR targeting the Rpt2 genes. Assay for\n                    <jats:italic>M. haemolytica<\/jats:italic>\n                    serotype A1 revealed all belong to A1. None of the isolates with cultural and morphological features of\n                    <jats:italic>P. multocida<\/jats:italic>\n                    gave positive results by molecular assay. Serological assay identified three serotypes of\n                    <jats:italic>M. haemolytica<\/jats:italic>\n                    namely A1, A2 and A7 almost in all of the samples whereas\n                    <jats:italic>P. multocida<\/jats:italic>\n                    serotype A was detected in 78.75% of the samples. The\n                    <jats:italic>M. haemolytica<\/jats:italic>\n                    isolates tested for susceptibility to antibiotics showed resistance against Bacitracin (83.33%) and Penicillin (50.00%) while they were found susceptible to Gentamycin (100%), Chloramphenicol (100%) and Sulfamethoxazole (100%) and Tetracycline (83.33%). In conclusion, the results of the present study revealed the association of\n                    <jats:italic>M. haemolytica<\/jats:italic>\n                    with pneumonic pasteurellosis in sheep and goats and can be of use in vaccine development in Ethiopia. Nevertheless, further investigations and continuous monitoring of antimicrobial resistance and appropriate selection and prudent use of antimicrobials in livestock sector are required.\n                  <\/jats:p>","DOI":"10.1038\/s41598-023-36026-2","type":"journal-article","created":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T14:02:13Z","timestamp":1685714533000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Identification of serotypes of Mannheimia haemolytica and Pasteurella multocida from pneumonic cases of sheep and goats and their antimicrobial sensitivity profiles in Borana and Arsi zones, Ethiopia"],"prefix":"10.1038","volume":"13","author":[{"given":"Sisay","family":"Girma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Latera","family":"Getachew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayele","family":"Beyene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desiye Tesfaye","family":"Tegegne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takele","family":"Tesgera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motuma","family":"Debelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarso","family":"Debano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dereje","family":"Teshome","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kebede","family":"Abdisa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abebe","family":"Wirtu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muluken","family":"Tekle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birhanu","family":"Abera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ketema","family":"Tafess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morka","family":"Dandecha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takele","family":"Abayneh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belayneh","family":"Getachew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takele Beyene","family":"Tufa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teshale Sori","family":"Tolera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,6,2]]},"reference":[{"key":"36026_CR1","doi-asserted-by":"publisher","first-page":"373642","DOI":"10.1155\/2014\/373642","volume":"2014","author":"A Kumar","year":"2014","unstructured":"Kumar, A., Tikoo, S. 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