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Doxorubicin (Dox) is known for its significant side effects caused by non-specific cytotoxicity. In this study, we investigated the antitumor activity of galloylquinic acids (BF) and the beneficial role of their combination with Dox in an Ehrlich ascites carcinoma (EAC)-bearing mouse model, as well as their cytotoxic effect on MCF-7 cells. The EAC-mice were randomized into five experimental groups: normal saline, Dox (2\u00a0mg\/kg, i.p), BF (150\u00a0mg\/kg, orally), Dox and BF combined mixture, and a control group. Mice were subjected to a 14-day treatment regimen. Results showed that BF compounds exerted\u00a0chemopreventive effects in EAC mice\u00a0group by increasing mean survival time, decreasing tumor volume, inhibiting ascites tumor cell count, modulating body weight changes, and preventing multi-organ histopathological alterations. BF\u00a0suppressed the increased levels of inflammatory mediators (IL-6 and TNF-\u03b1) and the angiogenic marker VEGF in the\u00a0ascitic fluid. In addition, BF and their combination with Dox exhibited\u00a0significant cytotoxic activity on MCF-7 cells by inhibiting cell viability and modulating\u00a0Annexin A1 level.\u00a0Moreover, BF treatments could revert oxidative stress, restore liver and kidney functions, and normalize blood cell counts.<\/jats:p>","DOI":"10.1038\/s41598-023-37654-4","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T17:02:43Z","timestamp":1690563763000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Suppression of VEGF and inflammatory cytokines, modulation of Annexin A1 and organ functions by galloylquinic acids in breast cancer model"],"prefix":"10.1038","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9920-1520","authenticated-orcid":false,"given":"Mohamed","family":"Abd El-Salam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghada","family":"El-Tanbouly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jairo","family":"Bastos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9593-4687","authenticated-orcid":false,"given":"Heba","family":"Metwaly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,7,28]]},"reference":[{"key":"37654_CR1","doi-asserted-by":"publisher","first-page":"314","DOI":"10.4103\/0973-1482.181173","volume":"14","author":"D Ceylan","year":"2018","unstructured":"Ceylan, D. et al. 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