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The study used 2007\u20132008 survey data from the National Health and Nutrition Examination Survey (NHANES). Data on urinary phthalates metabolites and serum thyroid function indicators were collected. The weighted multivariable linear regression models and Bayesian kernel machine regression (BKMR) analyses were used to analyze the relationship between phthalates metabolites and thyroid function. A total of 356 adolescents aged 12\u201319\u00a0years were included in the analysis. Linear regression models showed that mono-(carboxyisoctyl) phthalate (MCOP) was positively correlated with total triiodothyronine (TT3) (\u03b2\u2009=\u20090.045, 95% confidence interval\u00a0[CI] 0.022, 0.068) and thyroid stimulating hormone (TSH) (\u03b2\u2009=\u20090.1461, 95% CI 0.059, 0.232), while mono-(carboxyisononyl) phthalate (MCNP) was negatively correlated with TSH (\u03b2\u2009=\u2009\u2212\u00a00.119, 95% CI \u2212\u00a00.196, \u2212\u00a00.042). BKMR analyses showed phthalate metabolites mixtures have significantly positive overall effect on TT3. Exposure to phthalate mixtures might be positively correlated with increased TT3 serum level in US adolescents. The study provided evidence for the association between mixed phthalates exposure and thyroid health in adolescent population.<\/jats:p>","DOI":"10.1038\/s41598-023-38644-2","type":"journal-article","created":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T16:02:22Z","timestamp":1689696142000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The association between urinary phthalate metabolites and serum thyroid function in US adolescents"],"prefix":"10.1038","volume":"13","author":[{"given":"Shi-ting","family":"Xiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,7,18]]},"reference":[{"key":"38644_CR1","doi-asserted-by":"publisher","first-page":"51","DOI":"10.4274\/jcrpe.v3i2.11","volume":"3","author":"\u00d6 Tar\u0131m","year":"2011","unstructured":"Tar\u0131m, \u00d6. 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