{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:43:25Z","timestamp":1792622605679,"version":"4.5.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T00:00:00Z","timestamp":1691020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T00:00:00Z","timestamp":1691020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Glycopeptide antibiotics (vancomycin and teicoplanin) are usually used for the treatment of\n                    <jats:italic>Staphylococcus epidermidis<\/jats:italic>\n                    infections owing to their increased oxacillin resistance. However,\n                    <jats:italic>S. epidermidis<\/jats:italic>\n                    strains with decreased susceptibility to teicoplanin have become increasingly incident in recent years. We aimed to identify the characteristics of teicoplanin-non-susceptible (Teico-NS)\n                    <jats:italic>S. epidermidis<\/jats:italic>\n                    isolated at our hospital and analyze its relationship with teicoplanin usage. We retrospectively evaluated 328\n                    <jats:italic>S. epidermidis<\/jats:italic>\n                    strains isolated from clinical isolates between January 2016 and December 2021. All strains were susceptible to vancomycin (minimal inhibitory concentration (MIC)\u2009\u2264\u20094\u00a0mg\/L). The annual incidence for\n                    <jats:italic>S. epidermidis<\/jats:italic>\n                    strains with an elevated teicoplanin MIC of 8\u00a0mg\/L ranged from 22.2 to 28.9%. In addition, in 2021, the number of\n                    <jats:italic>S. epidermidis<\/jats:italic>\n                    strains with teicoplanin MIC\u2009\u2265\u200916\u00a0mg\/L rapidly increased (n\u2009=\u200913, 32.5%). Furthermore, teicoplanin use increased annually until 2019; however, in 2020, it decreased abruptly due to the COVID 19 pandemic. Thus, we could not confirm the existence of a clear correlation between teicoplanin usage and increased incidence of\n                    <jats:italic>S. epidermidis<\/jats:italic>\n                    with reduced teicoplanin-susceptibility. We showed the increased incidence of Teico-NS\n                    <jats:italic>S. epidermidis<\/jats:italic>\n                    in recent years. Further studies are needed to identify the mechanisms and risk factors for teicoplanin-resistance in\n                    <jats:italic>S. epidermidis.<\/jats:italic>\n                  <\/jats:p>","DOI":"10.1038\/s41598-023-39666-6","type":"journal-article","created":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T06:02:32Z","timestamp":1691042552000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Increased incidence of teicoplanin-non-susceptible Staphylococcus epidermidis strains: a 6-year retrospective study"],"prefix":"10.1038","volume":"13","author":[{"given":"Subin","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Phil","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Hyun","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Young","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunmi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,8,3]]},"reference":[{"key":"39666_CR1","first-page":"2432","volume-title":"Mandell, Douglas, and Bennett\u2019s Principles and Practice of Infectious Diseases","author":"ME Rupp","year":"2020","unstructured":"Rupp, M. 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