{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T07:48:08Z","timestamp":1777967288787,"version":"3.51.4"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T00:00:00Z","timestamp":1691625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T00:00:00Z","timestamp":1691625600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of this study was to investigate the effects of intraoperative fibrin glue use on surgery for blepharoptosis. This retrospective study included patients with acquired blepharoptosis who underwent surgical correction and were followed for at least one month. Patients were classified into two groups depending on whether treated with antithrombotic agents or otherwise. All patients taking antithrombotic agents discontinued with the treatment one week prior to surgery in accordance with our clinical guidelines. Preoperative and postoperative marginal reflex distance 1(MRD1) and ecchymosis grade were evaluated and compared. The subjects were 56 patients (111 eyes) who discontinued antithrombotic agents before surgery and 59 patients (117 eyes) who had never taken antithrombotic agents. Fibrin glue was used in 13 patients (26 eyes, 23.4%) in the antithrombotic group, and 11 patients (21 eyes, 17.9%) in the non-antithrombotic group. The rate of severe ecchymosis was significantly lower in patients who used fibrin glue in the antithrombotic group at 1\u00a0week (11.5 vs 40.0%, p\u2009=\u20090.008). However, in non-antithrombotic group, there was no difference in the rate of severe ecchymosis according to the use of fibrin glue at 1\u00a0week (14.3 vs 30.2%, p\u2009=\u20090.181). In patients with a history of taking antithrombotic agents, the intraoperative use of fibrin glue is thought to be helpful as it could significantly reduce significant ecchymosis.<\/jats:p>","DOI":"10.1038\/s41598-023-40183-9","type":"journal-article","created":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T10:03:10Z","timestamp":1691661790000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Intraoperative use of fibrin glue in blepharoplasty: a possible solution to reduce postoperative complication"],"prefix":"10.1038","volume":"13","author":[{"given":"Kangmin","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minwook","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,8,10]]},"reference":[{"issue":"Pt 2","key":"40183_CR1","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/eye.1988.33","volume":"2","author":"JR Collin","year":"1988","unstructured":"Collin, J. R. New concepts in the management of ptosis. Eye (Lond) 2(Pt 2), 185\u2013188. https:\/\/doi.org\/10.1038\/eye.1988.33 (1988).","journal-title":"Eye (Lond)"},{"key":"40183_CR2","first-page":"91","volume":"20","author":"JC Mesa Gutierrez","year":"2007","unstructured":"Mesa Gutierrez, J. C., Mascaro Zamora, F., Munoz Quinones, S., Prat Bertomeu, J. & Arruga Ginebreda, J. Upper eyelid surgery for treatment of congenital blepharoptosis. Cir Pediatr. 20, 91\u201395 (2007).","journal-title":"Cir Pediatr."},{"key":"40183_CR3","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.cps.2012.07.002","volume":"40","author":"KM Whipple","year":"2013","unstructured":"Whipple, K. M., Lim, L. H., Korn, B. S. & Kikkawa, D. O. Blepharoplasty complications: Prevention and management. Clin. Plast. Surg. 40, 213\u2013224. https:\/\/doi.org\/10.1016\/j.cps.2012.07.002 (2013).","journal-title":"Clin. Plast. Surg."},{"key":"40183_CR4","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/252368","volume":"2012","author":"J Oestreicher","year":"2012","unstructured":"Oestreicher, J. & Mehta, S. Complications of blepharoplasty: Prevention and management. Plast. Surg. Int. 2012, 252368. https:\/\/doi.org\/10.1155\/2012\/252368 (2012).","journal-title":"Plast. Surg. Int."},{"key":"40183_CR5","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1111\/j.1538-7836.2005.01204.x","volume":"3","author":"S Schulman","year":"2005","unstructured":"Schulman, S., Kearon, C., Subcommittee on Control of Anticoagulation of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis. Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. J. Thromb. Haemost. 3, 692\u2013694. https:\/\/doi.org\/10.1111\/j.1538-7836.2005.01204.x (2005).","journal-title":"J. Thromb. Haemost."},{"key":"40183_CR6","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1097\/01.iop.0000143711.48389.c5","volume":"20","author":"AN Hass","year":"2004","unstructured":"Hass, A. N., Penne, R. B., Stefanyszyn, M. A. & Flanagan, J. C. Incidence of postblepharoplasty orbital hemorrhage and associated visual loss. Ophthalmic Plast. Reconstr. Surg. 20, 426\u2013432. https:\/\/doi.org\/10.1097\/01.iop.0000143711.48389.c5 (2004).","journal-title":"Ophthalmic Plast. Reconstr. Surg."},{"key":"40183_CR7","doi-asserted-by":"publisher","first-page":"277e","DOI":"10.1097\/PRS.0000000000000919","volume":"135","author":"SMW Pool","year":"2015","unstructured":"Pool, S. M. W., van Exsel, D. C. E., Melenhorst, W., Cromheecke, M. & van der Lei, B. The effect of eyelid cooling on pain, edema, erythema, and hematoma after upper blepharoplasty: A randomized, controlled, observer-blinded evaluation study. Plast. Reconstr. Surg. 135, 277e\u2013281e. https:\/\/doi.org\/10.1097\/PRS.0000000000000919 (2015).","journal-title":"Plast. Reconstr. Surg."},{"key":"40183_CR8","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s00347-017-0617-5","volume":"115","author":"M Keseru","year":"2018","unstructured":"Keseru, M. et al. Postoperative care and options for scar treatment in eyelid surgery. Ophthalmologe 115, 283\u2013292. https:\/\/doi.org\/10.1007\/s00347-017-0617-5 (2018).","journal-title":"Ophthalmologe"},{"key":"40183_CR9","doi-asserted-by":"publisher","first-page":"182","DOI":"10.4103\/2452-2325.303201","volume":"33","author":"GA Garcia","year":"2021","unstructured":"Garcia, G. A., Bair, H. & Kossler, A. L. Perioperative management of antithrombotic medications: An investigation into current U. S. ophthalmologic recommendations. J. Curr. Ophthalmol. 33, 182\u2013188. https:\/\/doi.org\/10.4103\/2452-2325.303201 (2021).","journal-title":"J. Curr. Ophthalmol."},{"key":"40183_CR10","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.oftale.2020.11.001","volume":"96","author":"JC Herranz-Heras","year":"2021","unstructured":"Herranz-Heras, J. C. et al. Update on the perioperative management of antiplatelets and anticoagulants in ophthalmic surgery. Arch. Soc. Esp. Oftalmol. (Engl Ed) 96, 422\u2013429. https:\/\/doi.org\/10.1016\/j.oftale.2020.11.001 (2021).","journal-title":"Arch. Soc. Esp. Oftalmol. (Engl Ed)"},{"key":"40183_CR11","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.jacc.2019.01.011","volume":"74","author":"CT January","year":"2019","unstructured":"January, C. T. et al. 2019 AHA\/ACC\/HRS focused update of the 2014 AHA\/ACC\/HRS guideline for the management of patients with atrial fibrillation: A report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. J. Am. Coll. Cardiol. 74, 104\u2013132. https:\/\/doi.org\/10.1016\/j.jacc.2019.01.011 (2019).","journal-title":"J. Am. Coll. Cardiol."},{"key":"40183_CR12","doi-asserted-by":"publisher","first-page":"4013","DOI":"10.1093\/eurheartj\/ehab390","volume":"42","author":"V Aboyans","year":"2021","unstructured":"Aboyans, V. et al. Antithrombotic therapies in aortic and peripheral arterial diseases in 2021: A consensus document from the ESC working group on aorta and peripheral vascular diseases, the ESC working group on thrombosis, and the ESC working group on cardiovascular pharmacotherapy. Eur. Heart J. 42, 4013\u20134024. https:\/\/doi.org\/10.1093\/eurheartj\/ehab390 (2021).","journal-title":"Eur. Heart J."},{"key":"40183_CR13","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1097\/00000658-200206000-00009","volume":"235","author":"VA Ferraris","year":"2002","unstructured":"Ferraris, V. A., Ferraris, S. P., Joseph, O., Wehner, P. & Mentzer, R. M. Jr. Aspirin and postoperative bleeding after coronary artery bypass grafting. Ann. Surg. 235, 820\u2013827. https:\/\/doi.org\/10.1097\/00000658-200206000-00009 (2002).","journal-title":"Ann. Surg."},{"key":"40183_CR14","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1097\/01.NURSE.0000350767.47290.3f","volume":"39","author":"TN Nguyen","year":"2009","unstructured":"Nguyen, T. N. Aspirin-induced postoperative bleeding. Nursing 39, 64. https:\/\/doi.org\/10.1097\/01.NURSE.0000350767.47290.3f (2009).","journal-title":"Nursing"},{"key":"40183_CR15","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1136\/bmj.325.7368.828","volume":"325","author":"DA Fitzmaurice","year":"2002","unstructured":"Fitzmaurice, D. A., Blann, A. D. & Lip, G. Y. Bleeding risks of antithrombotic therapy. BMJ 325, 828\u2013831. https:\/\/doi.org\/10.1136\/bmj.325.7368.828 (2002).","journal-title":"BMJ"},{"key":"40183_CR16","doi-asserted-by":"publisher","first-page":"e456","DOI":"10.1097\/scs.0000000000008302","volume":"33","author":"K Lee","year":"2022","unstructured":"Lee, K. & Chang, M. Is it really safe to discontinue anticoagulant treatment before ptosis surgery from serious bleeding?. J. Craniofac. Surg. 33, e456\u2013e459. https:\/\/doi.org\/10.1097\/scs.0000000000008302 (2022).","journal-title":"J. Craniofac. Surg."},{"key":"40183_CR17","first-page":"3","volume":"49","author":"HP Spangler","year":"1976","unstructured":"Spangler, H. P. Tissue adhesion and local haemostasis using fibrinogen, thrombin and clotting factor XIII. (experimental investigations\u2013clinical experience) (author\u2019s transl). Wien Klin. Wochenschr. Suppl. 49, 3\u201318 (1976).","journal-title":"Wien Klin. Wochenschr. Suppl."},{"key":"40183_CR18","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/BF00190076","volume":"16","author":"MA Mandel","year":"1992","unstructured":"Mandel, M. A. Minimal suture blepharoplasty: Closure of incisions with autologous fibrin glue. Aesthet. Plast. Surg. 16, 269\u2013272. https:\/\/doi.org\/10.1007\/BF00190076 (1992).","journal-title":"Aesthet. Plast. Surg."},{"key":"40183_CR19","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/s1010-5182(96)80016-3","volume":"24","author":"MY Mommaerts","year":"1996","unstructured":"Mommaerts, M. Y. et al. Use of fibrin glue in lower blepharoplasties. J. Craniomaxillofac. Surg. 24, 78\u201382. https:\/\/doi.org\/10.1016\/s1010-5182(96)80016-3 (1996).","journal-title":"J. Craniomaxillofac. Surg."},{"key":"40183_CR20","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1007\/s00417-017-3898-0","volume":"256","author":"D Yorston","year":"2018","unstructured":"Yorston, D., Wong, D. & Joussen, A. Should we stop anti-thrombotic agents prior to vitrectomy?. Graefes Arch. Clin. Exp. Ophthalmol. 256, 459\u2013460. https:\/\/doi.org\/10.1007\/s00417-017-3898-0 (2018).","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"40183_CR21","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.oftal.2015.02.005","volume":"90","author":"G Crisci","year":"2015","unstructured":"Crisci, G., Mendoza Breczinski, C. & Magurno, M. Chronic antithrombotic therapy in cataract surgery: How much evidence do we have?. Arch. Soc. Esp. Oftalmol. 90, 403\u2013404. https:\/\/doi.org\/10.1016\/j.oftal.2015.02.005 (2015).","journal-title":"Arch. Soc. Esp. Oftalmol."},{"key":"40183_CR22","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1097\/00002341-200211000-00004","volume":"18","author":"PL Custer","year":"2002","unstructured":"Custer, P. L. & Trinkaus, K. M. Hemorrhagic complications of oculoplastic surgery. Ophthalmic Plast. Reconstr. Surg. 18, 409\u2013415. https:\/\/doi.org\/10.1097\/00002341-200211000-00004 (2002).","journal-title":"Ophthalmic Plast. Reconstr. Surg."},{"key":"40183_CR23","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1097\/00002341-199612000-00001","volume":"12","author":"GB Bartley","year":"1996","unstructured":"Bartley, G. B. Oculoplastic surgery in patients receiving warfarin: Suggestions for management. Ophthalmic Plast. Reconstr. Surg. 12, 229\u2013230. https:\/\/doi.org\/10.1097\/00002341-199612000-00001 (1996).","journal-title":"Ophthalmic Plast. Reconstr. Surg."},{"key":"40183_CR24","doi-asserted-by":"publisher","first-page":"e326S","DOI":"10.1378\/chest.11-2298","volume":"141","author":"JD Douketis","year":"2012","unstructured":"Douketis, J. D. et al. Perioperative management of antithrombotic therapy: Antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 141, e326S-e350S. https:\/\/doi.org\/10.1378\/chest.11-2298 (2012).","journal-title":"Chest"},{"key":"40183_CR25","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1097\/ICU.0000000000000187","volume":"26","author":"ES Esparaz","year":"2015","unstructured":"Esparaz, E. S. & Sobel, R. K. Perioperative management of anticoagulants and antiplatelet agents in oculoplastic surgery. Curr. Opin. Ophthalmol. 26, 422\u2013428. https:\/\/doi.org\/10.1097\/ICU.0000000000000187 (2015).","journal-title":"Curr. Opin. Ophthalmol."},{"key":"40183_CR26","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1136\/bjo.84.12.1426","volume":"84","author":"B Parkin","year":"2000","unstructured":"Parkin, B. & Manners, R. Aspirin and warfarin therapy in oculoplastic surgery. Br. J. Ophthalmol. 84, 1426\u20131427. https:\/\/doi.org\/10.1136\/bjo.84.12.1426 (2000).","journal-title":"Br. J. Ophthalmol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-023-40183-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-023-40183-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-023-40183-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T05:13:33Z","timestamp":1700284413000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-023-40183-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,10]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["40183"],"URL":"https:\/\/doi.org\/10.1038\/s41598-023-40183-9","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,10]]},"assertion":[{"value":"29 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"12982"}}