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We aimed to identify stimulation-dependent effects on motor activities, body weight, body composition, energy metabolism, and metabolic blood parameters and to determine if these alterations are associated with the local impact of DBS on different STN parcellations. We assessed 14 PD patients who underwent STN DBS (PD-DBS) before as well as 6- and 12-months post-surgery. For control purposes, 18 PD patients under best medical treatment (PD-CON) and 25 healthy controls (H-CON) were also enrolled. Wrist actigraphy, body composition, hormones, and energy expenditure measurements were applied. Electrode placement in the STN was localized, and the local impact of STN DBS was estimated. We found that STN DBS improved motor function by\u2009~\u200940% (DBS ON, Med ON). Weight and fat mass increased by\u2009~\u20093 kg and\u2009~\u20093% in PD-DBS (all <jats:italic>P<\/jats:italic>\u2009\u2264\u20090.005). fT3 (<jats:italic>P<\/jats:italic>\u2009=\u20090.001) and insulin levels (<jats:italic>P<\/jats:italic>\u2009=\u20090.048) increased solely in PD-DBS, whereas growth hormone levels (<jats:italic>P<\/jats:italic>\u2009=\u20090.001), daily physical activity, and VO<jats:sub>2<\/jats:sub> during walking were decreased in PD-DBS (all<jats:italic> P<\/jats:italic>\u2009\u2264\u20090.002). DBS of the limbic part of the STN was associated with changes in weight and body composition, sedentary activity, insulin levels (all<jats:italic> P<\/jats:italic>\u2009\u2264\u20090.040; all<jats:italic> r<\/jats:italic>\u2009\u2265\u20090.56), and inversely related to HOMA-IR (<jats:italic>P<\/jats:italic>\u2009=\u20090.033;<jats:italic> r<\/jats:italic>\u2009=\u2009<jats:italic>\u2212\u2009<\/jats:italic>0.62). Daily physical activity is decreased after STN DBS, which can contribute to weight gain and an unfavorable metabolic profile. We recommend actigraphy devices to provide feedback on daily activities to achieve pre-defined activity goals.<\/jats:p>","DOI":"10.1038\/s41598-023-40316-0","type":"journal-article","created":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T10:02:50Z","timestamp":1693389770000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Mechanisms and consequences of weight gain after deep brain stimulation of the subthalamic nucleus in patients with Parkinson\u2019s disease"],"prefix":"10.1038","volume":"13","author":[{"given":"Julia","family":"Steinhardt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Lokowandt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Rasche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Koch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Tronnier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F.","family":"M\u00fcnte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian M.","family":"Meyh\u00f6fer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britta","family":"Wilms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Br\u00fcggemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,8,30]]},"reference":[{"issue":"20","key":"40316_CR1","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1056\/NEJMoa035275","volume":"349","author":"P Krack","year":"2003","unstructured":"Krack, P. et al. 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