{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:13:58Z","timestamp":1792109638066,"version":"4.4.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:00:00Z","timestamp":1695686400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:00:00Z","timestamp":1695686400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Outcomes of conventional mechanical ventilation (CMV) and high-frequency oscillatory ventilation (HFOV) in patients with congenital diaphragmatic hernia (CDH) were compared through a systematic review and meta-analysis. Outcome measures included mortality and incidence of chronic lung disease (CLD). Odds ratio (OR) and 95% confidence interval (95%CI) were evaluated. Subgroup analyses were performed according to the strategy for applying HFOV in CDH patients. Group A: CMV was initially applied in all CDH patients, and HFOV was applied in unstable patients. Group B: chronologically analyzed. (CMV and HFOV era) Group C: CMV or HFOV was used as the initial MV. Of the 2199 abstracts screened, 15 full-text articles were analyzed. Regarding mortality, 16.7% (365\/2180) and 32.8% (456\/1389) patients died in CMV and HFOV, respectively (OR, 2.53; 95%CI 2.12\u20133.01). Subgroup analyses showed significantly worse, better, and equivalent mortality for HFOV than that for CMV in group A, B, and C, respectively. CLD occurred in 32.4% (399\/1230) and 49.3% (369\/749) patients in CMV and HFOV, respectively (OR, 2.37; 95%CI 1.93\u20132.90). The evidence from the literature is poor. Mortality and the incidence of CLD appear worse after HFOV in children with CDH. Cautious interpretation is needed due to the heterogeneity of each study.<\/jats:p>","DOI":"10.1038\/s41598-023-42344-2","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T17:03:05Z","timestamp":1695747785000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Comparison of conventional mechanical ventilation and high-frequency oscillatory ventilation in congenital diaphragmatic hernias: a systematic review and meta-analysis"],"prefix":"10.1038","volume":"13","author":[{"given":"Hee-Beom","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agostino","family":"Pierro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,9,26]]},"reference":[{"key":"42344_CR1","doi-asserted-by":"publisher","first-page":"2297","DOI":"10.1016\/j.jpedsurg.2020.06.022","volume":"55","author":"M Paoletti","year":"2020","unstructured":"Paoletti, M. et al. Prevalence and risk factors for congenital diaphragmatic hernia: A global view. J. Pediatr. Surg. 55, 2297\u20132307 (2020).","journal-title":"J. Pediatr. Surg."},{"key":"42344_CR2","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/s41572-022-00362-w","volume":"8","author":"A Zani","year":"2022","unstructured":"Zani, A. et al. Congenital diaphragmatic hernia. Nat. Rev. Dis. Primers. 8, 37 (2022).","journal-title":"Nat. Rev. Dis. Primers."},{"key":"42344_CR3","doi-asserted-by":"publisher","first-page":"1958","DOI":"10.1016\/j.jpedsurg.2015.09.010","volume":"50","author":"PS Puligandla","year":"2015","unstructured":"Puligandla, P. S. et al. Management of congenital diaphragmatic hernia: A systematic review from the APSA outcomes and evidence based practice committee. J. Pediatr. Surg. 50, 1958\u20131970 (2015).","journal-title":"J. Pediatr. Surg."},{"key":"42344_CR4","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1097\/SLA.0000000000001533","volume":"263","author":"KG Snoek","year":"2016","unstructured":"Snoek, K. G. et al. Conventional mechanical ventilation versus high-frequency oscillatory ventilation for congenital diaphragmatic hernia: A randomized clinical trial (The VICI-trial). Ann. Surg. 263, 867\u2013874 (2016).","journal-title":"Ann. Surg."},{"key":"42344_CR5","doi-asserted-by":"publisher","first-page":"131","DOI":"10.4103\/jiaps.JIAPS_179_17","volume":"23","author":"JS Aihole","year":"2018","unstructured":"Aihole, J. S. et al. A clinical study on congenital diaphragmatic hernia in neonates: Our institutional experience. J. Indian Assoc. Pediatr. Surg. 23, 131\u2013139 (2018).","journal-title":"J. Indian Assoc. Pediatr. Surg."},{"key":"42344_CR6","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/S0022-3468(97)90589-3","volume":"32","author":"K Azarow","year":"1997","unstructured":"Azarow, K. et al. Congenital diaphragmatic hernia\u2013a tale of two cities: The Toronto experience. J. Pediatr. Surg. 32, 395\u2013400 (1997).","journal-title":"J. Pediatr. Surg."},{"key":"42344_CR7","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1016\/j.jpedsurg.2013.02.002","volume":"48","author":"AL Beres","year":"2013","unstructured":"Beres, A. L., Puligandla, P. S., Brindle, M. E. & Capsnet,. Stability prior to surgery in Congenital Diaphragmatic Hernia: Is it necessary?. J Pediatr Surg 48, 919\u2013923 (2013).","journal-title":"J Pediatr Surg"},{"key":"42344_CR8","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1055\/s-2001-12204","volume":"11","author":"A Cacciari","year":"2001","unstructured":"Cacciari, A. et al. High-frequency oscillatory ventilation versus conventional mechanical ventilation in congenital diaphragmatic hernia. Eur. J. Pediatr. Surg. 11, 3\u20137 (2001).","journal-title":"Eur. J. Pediatr. Surg."},{"key":"42344_CR9","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1007\/s00383-020-04740-x","volume":"36","author":"G Derraugh","year":"2020","unstructured":"Derraugh, G. et al. High-frequency vs. conventional ventilation at the time of CDH repair is not associated with higher mortality and oxygen dependency: A retrospective cohort study. Pediatr. Surg. Int. 36, 1275\u20131280 (2020).","journal-title":"Pediatr. Surg. Int."},{"key":"42344_CR10","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1007\/s001340051284","volume":"26","author":"L Desfrere","year":"2000","unstructured":"Desfrere, L. et al. Impact of delayed repair and elective high-frequency oscillatory ventilation on survival of antenatally diagnosed congenital diaphragmatic hernia: First application of these strategies in the more \u201csevere\u201d subgroup of antenatally diagnosed newborns. Intensive Care Med 26, 934\u2013941 (2000).","journal-title":"Intensive Care Med"},{"issue":"4","key":"42344_CR11","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1038\/s41372-020-00833-6","volume":"41","author":"M Fuyuki","year":"2021","unstructured":"Fuyuki, M. et al. Prognosis of conventional vs. high-frequency ventilation for congenital diaphragmatic hernia: A retrospective cohort study. J. Perinatol. 41(4), 814\u2013823 (2021).","journal-title":"J. Perinatol."},{"key":"42344_CR12","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1111\/jpc.15659","volume":"58","author":"Y Khachane","year":"2022","unstructured":"Khachane, Y., Halliday, R., Thomas, G., Maheshwari, R. & Browning Carmo, K. Outcomes for infants with congenital diaphragmatic hernia: A single campus review with low extracorporeal membrane oxygenation utilisation. J. Paediatr. Child Health 58, 90\u201396 (2022).","journal-title":"J. Paediatr. Child Health"},{"key":"42344_CR13","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/s00383-007-2051-2","volume":"24","author":"GY Ng","year":"2008","unstructured":"Ng, G. Y. et al. Reduction in ventilator-induced lung injury improves outcome in congenital diaphragmatic hernia?. Pediatr. Surg. Int. 24, 145\u2013150 (2008).","journal-title":"Pediatr. Surg. Int."},{"key":"42344_CR14","doi-asserted-by":"publisher","first-page":"F320","DOI":"10.1136\/archdischild-2016-311432","volume":"102","author":"A O'Rourke-Potocki","year":"2017","unstructured":"O\u2019Rourke-Potocki, A., Ali, K., Murthy, V., Milner, A. & Greenough, A. Resuscitation of infants with congenital diaphragmatic hernia. Arch. Dis. Child Fetal Neonatal. Ed. 102, F320\u2013F323 (2017).","journal-title":"Arch. Dis. Child Fetal Neonatal. Ed."},{"key":"42344_CR15","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1016\/S0022-3468(98)90523-1","volume":"33","author":"C Reyes","year":"1998","unstructured":"Reyes, C. et al. Delayed repair of congenital diaphragmatic hernia with early high-frequency oscillatory ventilation during preoperative stabilization. J Pediatr Surg 33, 1010\u20131014 (1998).","journal-title":"J Pediatr Surg"},{"key":"42344_CR16","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1007\/s13312-019-1687-z","volume":"56","author":"T Sahoo","year":"2019","unstructured":"Sahoo, T. et al. Predictors of mortality among neonates with congenital diaphragmatic hernia: Experience from an inborn unselected cohort in India. Indian Pediatr. 56, 1037\u20131040 (2019).","journal-title":"Indian Pediatr."},{"key":"42344_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.asjsur.2015.02.005","volume":"40","author":"H Takayasu","year":"2017","unstructured":"Takayasu, H. et al. Analysis of risk factors of long-term complications in congenital diaphragmatic hernia: A single institution\u2019s experience. Asian J Surg 40, 1\u20135 (2017).","journal-title":"Asian J Surg"},{"issue":"4","key":"42344_CR18","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1159\/000316974","volume":"98","author":"L van den Hout","year":"2010","unstructured":"van den Hout, L. et al. Risk factors for chronic lung disease and mortality in newborns with congenital diaphragmatic hernia. Neonatology 98(4), 370\u2013380 (2010).","journal-title":"Neonatology"},{"key":"42344_CR19","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1186\/cc2987","volume":"9","author":"SH Vitali","year":"2005","unstructured":"Vitali, S. H. & Arnold, J. H. Bench-to-bedside review: Ventilator strategies to reduce lung injury\u2014lessons from pediatric and neonatal intensive care. Crit. Care 9, 177\u2013183 (2005).","journal-title":"Crit. Care"},{"key":"42344_CR20","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1007\/s00383-009-2425-8","volume":"25","author":"L van den Hout","year":"2009","unstructured":"van den Hout, L. et al. Can we improve outcome of congenital diaphragmatic hernia?. Pediatr. Surg. Int. 25, 733\u2013743 (2009).","journal-title":"Pediatr. Surg. Int."},{"key":"42344_CR21","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1016\/j.jpedsurg.2009.07.025","volume":"45","author":"MA Kuluz","year":"2010","unstructured":"Kuluz, M. A. et al. Preliminary observations of the use of high-frequency jet ventilation as rescue therapy in infants with congenital diaphragmatic hernia. J. Pediatr. Surg. 45, 698\u2013702 (2010).","journal-title":"J. Pediatr. Surg."},{"key":"42344_CR22","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1053\/j.sempedsurg.2007.01.006","volume":"16","author":"JW Logan","year":"2007","unstructured":"Logan, J. W., Cotten, C. M., Goldberg, R. N. & Clark, R. H. Mechanical ventilation strategies in the management of congenital diaphragmatic hernia. Semin. Pediatr. Surg. 16, 115\u2013125 (2007).","journal-title":"Semin. Pediatr. Surg."},{"key":"42344_CR23","doi-asserted-by":"publisher","first-page":"986","DOI":"10.3390\/children9070986","volume":"9","author":"C Wegele","year":"2022","unstructured":"Wegele, C. et al. Impact of time point of extracorporeal membrane oxygenation on mortality and morbidity in congenital diaphragmatic hernia: A single-center case series. Children 9, 986 (2022).","journal-title":"Children"},{"key":"42344_CR24","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.21037\/tp-20-142","volume":"10","author":"MJ Yang","year":"2021","unstructured":"Yang, M. J., Russell, K. W., Yoder, B. A. & Fenton, S. J. Congenital diaphragmatic hernia: A narrative review of controversies in neonatal management. Transl. Pediatr. 10, 1432\u20131447 (2021).","journal-title":"Transl. Pediatr."},{"key":"42344_CR25","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1159\/000438978","volume":"109","author":"KG Snoek","year":"2016","unstructured":"Snoek, K. G. et al. Neurodevelopmental outcome in high-risk congenital diaphragmatic hernia patients: An appeal for international standardization. Neonatology 109, 14\u201321 (2016).","journal-title":"Neonatology"},{"key":"42344_CR26","doi-asserted-by":"publisher","first-page":"40","DOI":"10.29390\/cjrt-2019-004","volume":"55","author":"M Meyers","year":"2019","unstructured":"Meyers, M., Rodrigues, N. & Ari, A. High-frequency oscillatory ventilation: A narrative review. Can J Respir Ther 55, 40\u201346 (2019).","journal-title":"Can J Respir Ther"},{"key":"42344_CR27","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1053\/jpsu.2001.20031","volume":"36","author":"CS Muratore","year":"2001","unstructured":"Muratore, C. S. et al. Pulmonary morbidity in 100 survivors of congenital diaphragmatic hernia monitored in a multidisciplinary clinic. J. Pediatr. Surg. 36, 133\u2013140 (2001).","journal-title":"J. Pediatr. Surg."},{"key":"42344_CR28","doi-asserted-by":"crossref","unstructured":"Cools F, Offringa M, Askie LM. Elective high frequency oscillatory ventilation versus conventional ventilation for acute pulmonary dysfunction in preterm infants. Cochrane Database Syst. Rev. CD000104 (2015)","DOI":"10.1002\/14651858.CD000104.pub4"},{"issue":"2","key":"42344_CR29","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1056\/NEJMoa2026983","volume":"385","author":"JA Deprest","year":"2021","unstructured":"Deprest, J. A. et al. Randomized trial of fetal surgery for moderate left diaphragmatic hernia. N. Engl. J. Med. 385(2), 119\u2013129 (2021).","journal-title":"N. Engl. J. Med."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-023-42344-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-023-42344-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-023-42344-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T23:28:15Z","timestamp":1700350095000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-023-42344-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,26]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["42344"],"URL":"https:\/\/doi.org\/10.1038\/s41598-023-42344-2","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,26]]},"assertion":[{"value":"27 February 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 September 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"16136"}}