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In this study, we investigated whether these <jats:italic>PDGFRA<\/jats:italic> polymorphisms are associated with corneal astigmatism in a Japanese population. We recruited 1,535 cases with corneal astigmatism (mean corneal cylinder power across both eyes:\u2009\u2264\u2009\u2009\u2212\u20090.75 diopters [D]) and 842 controls (&gt;\u2009\u2212\u20090.75 D) to genotype 13 single-nucleotide polymorphisms (SNPs) in the <jats:italic>PDGFRA<\/jats:italic> gene region. We also performed imputation analysis in the region, with 179 imputed SNPs included in the statistical analyses. The <jats:italic>PDGFRA<\/jats:italic> SNPs were not significantly associated with the cases with corneal astigmatism\u2009\u2264\u2009\u2009\u2212\u20090.75 D. However, the odds ratios (ORs) of the minor alleles of SNPs in the upstream region of <jats:italic>PDGFRA<\/jats:italic>, including rs7673984, rs4864857, and rs11133315, tended to increase according to the degree of corneal astigmatism, and these SNPs were significantly associated with the cases with corneal astigmatism\u2009\u2264\u2009\u2009\u2212\u20091.25 D or\u2009\u2264\u2009\u2009\u2212\u20091.50 D (<jats:italic>P<\/jats:italic>c\u2009&lt;\u20090.05, OR\u2009=\u20091.34\u20131.39). These results suggest that <jats:italic>PDGFRA<\/jats:italic> SNPs play a potential role in the development of greater corneal astigmatism.<\/jats:p>","DOI":"10.1038\/s41598-023-43333-1","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T10:02:56Z","timestamp":1695722576000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association of PDGFRA polymorphisms with the risk of corneal astigmatism in a Japanese population"],"prefix":"10.1038","volume":"13","author":[{"given":"Hideharu","family":"Fukasaku","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Meguro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhisa","family":"Mizuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Ota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kengo","family":"Funakoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,9,26]]},"reference":[{"key":"43333_CR1","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/j.1444-0938.2007.00112.x","volume":"90","author":"SA Read","year":"2007","unstructured":"Read, S. 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