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Thus, studies with the application of new probiotic products are needed in the prevention\/treatment of these clinical conditions. The objective of this work was to evaluate the effects of probiotic orange juice containing <jats:italic>Pediococcus acidilactici<\/jats:italic> CE51 in a murine model of colitis. 45 male Swiss lineage mice were used, divided into five groups (n\u2009=\u20099): control, colitis, colitis\u2009+\u2009probiotic (probiotic orange juice containing CE51), colitis\u2009+\u2009placebo (orange juice) and colitis\u2009+\u2009sulfasalazine (10\u00a0mg\/kg\/Weight). The induction of colitis was performed with dextran sodium sulfate (3%). The treatment time was 5 and 15\u00a0days after induction. Histopathological analysis, serum measurements of TNF-\u03b1 and C-reactive protein and metagenomic analysis of feces were performed after euthanasia. Probiotic treatment reduced inflammation in the small intestine, large intestine and spleen. The probiotic did not alter the serum dosages of TNF-\u03b1 and C-reactive protein. Their use maintained the quantitative ratio of the phylum <jats:italic>Firmicutes\/Bacteroidetes<\/jats:italic> and increased <jats:italic>Lactobacillus helveticus<\/jats:italic> with 15\u00a0days of treatment (p\u2009&lt;\u20090.05). The probiotic orange juice containing <jats:italic>P. acidilactici<\/jats:italic> CE51 positively modulated the gut microbiota composition and attenuated the inflammation induced in colitis.<\/jats:p>","DOI":"10.1038\/s41598-023-45819-4","type":"journal-article","created":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T13:01:31Z","timestamp":1698498091000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Orange juice containing Pediococcus acidilactici CE51 modulates the intestinal microbiota and reduces induced inflammation in a murine model of colitis"],"prefix":"10.1038","volume":"13","author":[{"given":"Karolinny Cristiny","family":"de Oliveira Vieira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Beatriz Batista","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suelen Aparecida","family":"Fel\u00edcio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1bio Santos","family":"Lira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ca\u00edque","family":"de Figueiredo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia","family":"Bezirtzoglou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9ria Cataneli","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilson Romero","family":"Nakagaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisele Alborghetti","family":"Nai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizziane Kretli","family":"Winkelstr\u00f6ter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,10,28]]},"reference":[{"key":"45819_CR1","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1016\/j.suc.2019.08.001","volume":"99","author":"S Flynn","year":"2019","unstructured":"Flynn, S. & Eisenstein, S. 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