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Smooth muscle [Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ] is a key determinant of constriction, tied to L-type (Ca\n                    <jats:sub>V<\/jats:sub>\n                    1.2) Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channels. While important, other Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channels, particularly T-type could contribute to pressure regulation within defined voltage ranges. This study examined the role of one T-type Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channel (Ca\n                    <jats:sub>V<\/jats:sub>\n                    3.1) using C57BL\/6 wild type and Ca\n                    <jats:sub>V<\/jats:sub>\n                    3.1\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice. Patch-clamp electrophysiology, pressure myography, blood pressure and Ca\n                    <jats:sup>2+<\/jats:sup>\n                    imaging defined the Ca\n                    <jats:sub>V<\/jats:sub>\n                    3.1\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    phenotype relative to C57BL\/6. Ca\n                    <jats:sub>V<\/jats:sub>\n                    3.1\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice had absent Ca\n                    <jats:sub>V<\/jats:sub>\n                    3.1 expression and whole-cell current, coinciding with lower blood pressure and reduced mesenteric artery myogenic tone, particularly at lower pressures (20\u201360\u00a0mmHg) where membrane potential is hyperpolarized. This reduction coincided with diminished Ca\n                    <jats:sup>2+<\/jats:sup>\n                    wave generation, asynchronous events of Ca\n                    <jats:sup>2+<\/jats:sup>\n                    release from the sarcoplasmic reticulum, insensitive to L-type Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channel blockade (Nifedipine, 0.3\u00a0\u00b5M). Proximity ligation assay (PLA) confirmed IP\n                    <jats:sub>3<\/jats:sub>\n                    R1\/Ca\n                    <jats:sub>V<\/jats:sub>\n                    3.1 close physical association. IP\n                    <jats:sub>3<\/jats:sub>\n                    R blockade (2-APB, 50\u00a0\u00b5M or xestospongin C, 3\u00a0\u00b5M) in nifedipine-treated C57BL\/6 arteries rendered a Ca\n                    <jats:sub>V<\/jats:sub>\n                    3.1\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    contractile phenotype. Findings indicate that Ca\n                    <jats:sup>2+<\/jats:sup>\n                    influx through Ca\n                    <jats:sub>V<\/jats:sub>\n                    3.1 contributes to myogenic tone at hyperpolarized voltages through Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -induced Ca\n                    <jats:sup>2+<\/jats:sup>\n                    release tied to the sarcoplasmic reticulum. This study helps establish Ca\n                    <jats:sub>V<\/jats:sub>\n                    3.1 as a potential therapeutic target to control blood pressure.\n                  <\/jats:p>","DOI":"10.1038\/s41598-023-47715-3","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T16:03:09Z","timestamp":1700582589000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["CaV3.1 channels facilitate calcium wave generation and myogenic tone development in mouse mesenteric arteries"],"prefix":"10.1038","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9139-3158","authenticated-orcid":false,"given":"Mohammed A.","family":"El-Lakany","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Haghbin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naman","family":"Arora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed M.","family":"Hashad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galina Yu.","family":"Mironova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Sancho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Gros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5174-186X","authenticated-orcid":false,"given":"Donald G.","family":"Welsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,11,21]]},"reference":[{"key":"47715_CR1","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1038\/nn2003","volume":"10","author":"C Iadecola","year":"2007","unstructured":"Iadecola, C. & Nedergaard, M. 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