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In a first, we report altered grain nutrients profile of modern-bred rice and wheat cultivars diminishing their mineral dietary significance to the Indian population. To substantiate, we evaluated grain nutrients profile of historical landmark high-yielding cultivars of rice and wheat released in succeeding decades since the GR and its impacts on mineral diet quality and human health, with a prediction for decades ahead. Analysis of grain nutrients profile shows a downward trend in concentrations of essential and beneficial elements, but an upward in toxic elements in past 50 y in both rice and wheat. For example, zinc (Zn) and iron (Fe) concentration in grains of rice decreased by ~\u200933.0 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and 27.0% (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001); while for wheat it decreased by ~\u200930.0 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001) and 19.0% (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001) in past more than 50 y, respectively. A proposed mineral-diet quality index (M-DQI) significantly (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001) decreased ~\u200957.0 and 36.0% in the reported time span (1960\u20132010)\u00a0in rice and wheat, respectively. The impoverished M-DQI could impose hostile effects on non-communicable diseases (NCDs) like iron-deficiency anemia, respiratory, cardiovascular, and musculoskeletal among the Indian population by 2040. Our research calls for an urgency of grain nutrients profiling before releasing a cultivar of staples like rice and wheat in the future.<\/jats:p>","DOI":"10.1038\/s41598-023-48488-5","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T20:02:08Z","timestamp":1701374528000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Historical shifting in grain mineral density of landmark rice and wheat cultivars released over the past 50\u00a0years in India"],"prefix":"10.1038","volume":"13","author":[{"given":"Sovan","family":"Debnath","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahana","family":"Dey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubina","family":"Khanam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susmit","family":"Saha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dibyendu","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayanta K.","family":"Saha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mounissamy V.","family":"Coumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhaskar C.","family":"Patra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tufleuddin","family":"Biswas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mrinmoy","family":"Ray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhari S.","family":"Radhika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biswapati","family":"Mandal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,11,30]]},"reference":[{"key":"48488_CR1","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1038\/s43016-020-00157-w","volume":"1","author":"K Damerau","year":"2020","unstructured":"Damerau, K. et al. 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