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A retrospective review of medical charts was conducted for 457 eyes of 277 patients, with the age at surgery averaging 1.3\u2009\u00b1\u20091.5\u00a0years (mean\u2009\u00b1\u2009SD) and the follow-up duration averaging 12.8\u2009\u00b1\u20092.4\u00a0years (ranging from 10 to 17\u00a0years). The cohort included 250 eyes of 125 cases with bilateral aphakia (age at surgery 0.5\u2009\u00b1\u20090.8\u00a0years), 110 eyes of 55 cases with bilateral pseudophakia (1.9\u2009\u00b1\u20091.6\u00a0years), 42 cases with unilateral aphakia (1.1\u2009\u00b1\u20091.3\u00a0years), and 55 cases with unilateral pseudophakia (2.6\u2009\u00b1\u20091.7). A forward stepwise multiple regression analysis revealed that the best-corrected visual acuity at the final visit was significantly associated with laterality of cataract (with bilateral cases showing better results compared to unilateral cases), presence of systemic comorbidities, presence of ocular comorbidities, development of glaucoma, and phakic status (with better results in the pseudophakia group than the aphakia group). The age at surgery did not significantly affect visual acuity outcomes. A multiple logistic regression analysis demonstrated that the incidence of secondary glaucoma was significantly linked to younger age at surgery, phakic status (higher in aphakic than pseudophakic eyes), and presence of systemic comorbidities. In conclusion, after pediatric cataract surgery, final visual acuity was better in patients with bilateral cataracts, those treated with an intraocular lens, and cases without systemic or ocular comorbidities and secondary glaucoma. The development of secondary glaucoma was linked to younger age at surgery, aphakic status, and presence of systemic comorbidities.<\/jats:p>","DOI":"10.1038\/s41598-023-49166-2","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T04:23:50Z","timestamp":1702009430000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Long-term surgical outcomes of pediatric cataract\u2014multivariate analysis of prognostic factors"],"prefix":"10.1038","volume":"13","author":[{"given":"Tetsuro","family":"Oshika","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Endo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daijiro","family":"Kurosaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Matsuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Miyagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Nagamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuno","family":"Negishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachiko","family":"Nishina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Nomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Unoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeo","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,12,8]]},"reference":[{"key":"49166_CR1","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1038\/s41433-020-1115-6","volume":"34","author":"JE Self","year":"2020","unstructured":"Self, J. 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Drs. Oshika, Negishi, and Yoshida have received grant supports from Alcon Laboratories, Inc., Johnson &amp; Johnson Vision, and HOYA. Dr. Kurosaka has received grant supports from Alcon Laboratories, Inc. and HOYA. Dr. Mori has received grant supports from Alcon Laboratories, Inc. None of the other authors has any financial or proprietary interest in any material or method mentioned.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"21645"}}