{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:17:26Z","timestamp":1780085846251,"version":"3.54.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T00:00:00Z","timestamp":1704240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T00:00:00Z","timestamp":1704240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Zun City Kehe","award":["HZ-2023-284"],"award-info":[{"award-number":["HZ-2023-284"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objective of this study was retrospectively to analyze the clinical characteristics and <jats:sup>18<\/jats:sup>F-FDG PET\/CT findings in Meigs syndrome (MS) patients. A total of 21 patients with MS induced by ovarian stromal tumors and 69 patients with pseudo-MS caused by ovarian cancer (OC-PMS) were subjected to evaluation using <jats:sup>18<\/jats:sup>F-FDG PET\/CT. Visual and semi-quantitative methods were employed to analyze the PET\/CT findings. Visual analysis included recording whether the density of the primary tumor was uniform, whether there were cystic changes and calcifications, and the location of serous fluid accumulation. Semi-quantitative analysis involved the measurement of the tumor size, SUVmax, and SUVmean. No significant difference was observed in the size and density of primary tumors between the MS group and the OC-PMS group. However, the SUVmax and SUVmean of tumors in the MS group were found to be significantly lower than those in the OC-PMS group. The amount of serous cavity effusion caused by ovarian sex cord stromal tumors was found to be unrelated to the size of the tumor, SUVmax, and SUVmean but was positively correlated with the level of Ca125. MS patients have both benign ovarian tumors and ascites and\/or pleural effusion, which may be accompanied by elevated Ca125 levels. This should be considered as one of the differential diagnoses for ovarian cancer. Understanding the PET\/CT features of MS can facilitate the attainment of an accurate diagnosis before surgery.<\/jats:p>","DOI":"10.1038\/s41598-024-51186-5","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T15:02:35Z","timestamp":1704294155000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["18F-FDG PET\/CT features of Meigs syndrome induced by ovarian sex cord stromal tumors: a retrospective clinical study"],"prefix":"10.1038","volume":"14","author":[{"given":"Xianwen","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiong","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,3]]},"reference":[{"issue":"5","key":"51186_CR1","first-page":"471","volume":"3","author":"JV Meigs","year":"1954","unstructured":"Meigs, J. V. Pelvic tumors other than fibromas of the ovary with ascites and hydrothorax. Obstet. Gynecol. 3(5), 471\u2013486 (1954).","journal-title":"Obstet. Gynecol."},{"issue":"1","key":"51186_CR2","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1097\/LBR.0b013e31827ccb35","volume":"20","author":"D Riker","year":"2013","unstructured":"Riker, D. & Goba, D. Ovarian mass, pleural effusion, and ascites: revisiting Meigs syndrome. J. Bronchol. Interv. Pulmonol. 20(1), 48\u201351 (2013).","journal-title":"J. Bronchol. Interv. Pulmonol."},{"key":"51186_CR3","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1097\/CCO.0000000000000860","volume":"34","author":"S Negri","year":"2022","unstructured":"Negri, S., Grassi, T. & Fruscio, R. Use of staging for sex cord stromal tumours. Curr. Opin. Oncol. 34, 504\u2013510 (2022).","journal-title":"Curr. Opin. Oncol."},{"issue":"3","key":"51186_CR4","doi-asserted-by":"publisher","first-page":"232","DOI":"10.48095\/ccko2022232","volume":"35","author":"L Kristkov\u00e1","year":"2022","unstructured":"Kristkov\u00e1, L. et al. Meigs syndrome. Klin. Onkol. 35(3), 232\u2013234 (2022).","journal-title":"Klin. Onkol."},{"issue":"49","key":"51186_CR5","doi-asserted-by":"publisher","first-page":"e2114","DOI":"10.1097\/MD.0000000000002114","volume":"94","author":"R Krenke","year":"2015","unstructured":"Krenke, R. et al. Pleural effusion in Meigs\u2019 syndrome-transudate or exudate? Systematic review of the literature. Medicine 94(49), e2114 (2015).","journal-title":"Medicine"},{"issue":"3","key":"51186_CR6","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1067\/mob.2001.110028","volume":"184","author":"Y Abramov","year":"2001","unstructured":"Abramov, Y., Anteby, S. O., Fasouliotis, S. J. & Barak, V. Markedly elevated levels of vascular endothelial growth factor, fibroblast growth factor, and interleukin 6 in Meigs syndrome. Am. J. Obstet. Gynecol. 184(3), 354\u2013355 (2001).","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"1","key":"51186_CR7","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/S0301-2115(01)00290-1","volume":"98","author":"O Ishiko","year":"2001","unstructured":"Ishiko, O., Yoshida, H., Sumi, T., Hirai, K. & Ogita, S. Vascular endothelial growth factor levels in pleural and peritoneal fluid in Meigs\u2019 syndrome. Eur. J. Obstet. Gynecol. Reprod. Biol. 98(1), 129\u2013130 (2001).","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"issue":"34","key":"51186_CR8","doi-asserted-by":"publisher","first-page":"e11926","DOI":"10.1097\/MD.0000000000011926","volume":"97","author":"Y Shen","year":"2018","unstructured":"Shen, Y. et al. Ovarian fibroma\/fibrothecoma with elevated serum CA125 level: A cohort of 66 cases. Medicine 97(34), e11926 (2018).","journal-title":"Medicine"},{"issue":"7","key":"51186_CR9","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1016\/0002-9378(71)90958-6","volume":"111","author":"JV Meigs","year":"1971","unstructured":"Meigs, J. V. & Cass, J. W. Fibroma of the ovary with ascites and hydrothorax: With a report of seven cases. Am. J. Obstet. Gynecol. 111(7), 993 (1971).","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"5","key":"51186_CR10","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1016\/0002-9378(54)90258-6","volume":"67","author":"JV Meigs","year":"1954","unstructured":"Meigs, J. V. Fibroma of the ovary with ascites and hydrothorax; Meigs\u2019 syndrome. Am. J. Obstet. Gynecol. 67(5), 962\u2013985 (1954).","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"10177","key":"51186_CR11","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1016\/S0140-6736(18)32552-2","volume":"393","author":"S Lheureux","year":"2019","unstructured":"Lheureux, S., Gourley, C., Vergote, I. & Oza, A. M. Epithelial ovarian cancer. Lancet 393(10177), 1240\u20131253 (2019).","journal-title":"Lancet"},{"issue":"12","key":"51186_CR12","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1016\/S1701-2163(16)30596-5","volume":"24","author":"MC Renaud","year":"2002","unstructured":"Renaud, M. C., Plante, M. & Roy, M. Ovarian thecoma associated with a large quantity of ascites and elevated serum CA 125 and CA 15-3. J. Obstet. Gynaecol. Can. 24(12), 963\u2013965 (2002).","journal-title":"J. Obstet. Gynaecol. Can."},{"issue":"Suppl 1","key":"51186_CR13","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1136\/ijgc-00009577-200602001-00053","volume":"16","author":"A Mor\u00e1n-Mendoza","year":"2006","unstructured":"Mor\u00e1n-Mendoza, A. et al. Elevated CA125 level associated with Meigs\u2019 syndrome: Case report and review of the literature. Int. J. Gynecol. Cancer. 16(Suppl 1), 315\u2013318 (2006).","journal-title":"Int. J. Gynecol. Cancer."},{"issue":"1","key":"51186_CR14","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1007\/s11684-019-0732-6","volume":"15","author":"W Shang","year":"2021","unstructured":"Shang, W. et al. Clinical laboratory features of Meigs\u2019 syndrome: A retrospective study from 2009 to 2018. Front. Med. 15(1), 116\u2013124 (2021).","journal-title":"Front. Med."},{"issue":"1","key":"51186_CR15","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s12890-016-0241-1","volume":"16","author":"K Okuda","year":"2016","unstructured":"Okuda, K. et al. A case of Meigs\u2019 syndrome with preceding pericardial effusion in advance of pleural effusion. BMC Pulm. Med. 16(1), 71 (2016).","journal-title":"BMC Pulm. Med."},{"issue":"3","key":"51186_CR16","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/s13139-011-0093-9","volume":"45","author":"ES Lee","year":"2011","unstructured":"Lee, E. S., Kim, T. S., Yoo, C. W., Seo, S. S. & Kim, S. K. A case of Meigs\u2019 syndrome: The (18)F-FDG PET\/CT findings. Nucl. Med. Mol. Imaging 45(3), 229\u2013232 (2011).","journal-title":"Nucl. Med. Mol. Imaging"},{"issue":"1","key":"51186_CR17","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1186\/s12885-021-08815-3","volume":"21","author":"X Hu","year":"2021","unstructured":"Hu, X. et al. Indirect comparison of the diagnostic performance of (18)F-FDG PET\/CT and MRI in differentiating benign and malignant ovarian or adnexal tumors: A systematic review and meta-analysis. BMC Cancer 21(1), 1080 (2021).","journal-title":"BMC Cancer"},{"key":"51186_CR18","doi-asserted-by":"publisher","first-page":"840433","DOI":"10.3389\/fonc.2022.840433","volume":"12","author":"X Hu","year":"2022","unstructured":"Hu, X. et al. The diagnostic performance of maximum uptake value and apparent diffusion coefficient in differentiating benign and malignant ovarian or adnexal masses: A meta-analysis. Front. Oncol. 12, 840433 (2022).","journal-title":"Front. Oncol."},{"issue":"4","key":"51186_CR19","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/S0735-6757(98)90141-3","volume":"16","author":"L Kazanov","year":"1998","unstructured":"Kazanov, L., Ander, D. S., Enriquez, E. & Jaggi, F. M. Pseudo-Meigs\u2019 syndrome. Am. J. Emerg. Med. 16(4), 404\u2013405 (1998).","journal-title":"Am. J. Emerg. Med."},{"issue":"5","key":"51186_CR20","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1007\/s00259-014-2698-6","volume":"41","author":"N Jehanno","year":"2014","unstructured":"Jehanno, N. et al. 18F-FDG PET\/CT findings in uterine leiomyomas. Eur. J. Nucl. Med. Mol. Imaging 41(5), 1034\u20131035 (2014).","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"51186_CR21","unstructured":"Mohammed SA, Kumar A. StatPearls. 2023. Treasure Island (FL)."},{"issue":"5","key":"51186_CR22","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1007\/s00404-017-4515-5","volume":"296","author":"AS Lagan\u00e0","year":"2017","unstructured":"Lagan\u00e0, A. S. et al. Epigenetic and genetic landscape of uterine leiomyomas: A current view over a common gynecological disease. Arch. Gynecol. Obstet. 296(5), 855\u2013867 (2017).","journal-title":"Arch. Gynecol. Obstet."},{"issue":"2","key":"51186_CR23","first-page":"103","volume":"20","author":"G Stabile","year":"2021","unstructured":"Stabile, G. et al. Pelvic mass, ascites, hydrothorax: a malignant or benign condition? Meigs syndrome with high levels of CA 125. Prz. Menopauzalny 20(2), 103\u2013107 (2021).","journal-title":"Prz. Menopauzalny"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-51186-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-51186-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-51186-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T15:03:20Z","timestamp":1704294200000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-51186-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,3]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["51186"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-51186-5","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,3]]},"assertion":[{"value":"16 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"347"}}