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The study investigated how CSES impacts oxidative stress markers (i.e., malondialdehyde\/MDA, glutathione\/GSH and catalase), inflammation marker (i.e., Interleukin-6\/IL-6), cellular senescence markers (i.e., senescence-associated \u03b2-galactoside\/SA-\u03b2-Gal activity and p16), brain damage marker (i.e., Neuron-specific Enolase\/NSE), and neurogenesis markers (i.e., mature Brain-derived Neurotropic Factor\/BDNF, pro-BDNF, and mature\/pro-BDNF ratio). Male adult Wistar rats were fed a high-fat diet and given CSES once daily, at 100\u00a0mg\/kg body weight, for 12\u00a0weeks. CSES significantly reduced MDA concentration (p\u00a0=\u2009&lt;\u20090.001), SA-\u03b2-Gal activity (p\u2009=\u20090.010), and increased GSH concentration (p\u2009=\u20090.047) in the brain of obese rats; however, the decrease of IL-6, NSE, and p16 as well as the increase of catalase specific activity and BDNF expression were not significant. Moreover, the mature\/pro-BDNF ratio was significantly higher in the brains of non-obese rats, both given the control diet and the\u00a0high-fat diet compared to the control. Our results suggest that obese rats benefited from consuming CSES, showing improved oxidative stress levels, reduced cellular senescence and increased endogenous antioxidants, making CSES a potential neuroprotective agent.<\/jats:p>","DOI":"10.1038\/s41598-024-51221-5","type":"journal-article","created":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T12:02:18Z","timestamp":1704456138000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Exploration of neuroprotective effect from Coriandrum sativum L. ethanolic seeds extracts on brain of obese rats"],"prefix":"10.1038","volume":"14","author":[{"given":"Novi Silvia","family":"Hardiany","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Putri Krishna Kumara","family":"Dewi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syarifah","family":"Dewi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bimo A.","family":"Tejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,5]]},"reference":[{"key":"51221_CR1","unstructured":"World Health Organization. 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