{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T23:13:29Z","timestamp":1781133209146,"version":"3.54.1"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:00:00Z","timestamp":1705017600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:00:00Z","timestamp":1705017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"the Science and Technology Development Foundation of Chongming District Shanghai","award":["CKY2020-29"],"award-info":[{"award-number":["CKY2020-29"]}]},{"name":"Sanghai Municipal Health Bureau","award":["202340117"],"award-info":[{"award-number":["202340117"]}]},{"name":"National Science Foundation of Colleges and Universities Anhui provinces, China","award":["2023AH053425"],"award-info":[{"award-number":["2023AH053425"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Acute Myocardial Infarction (AMI) after Percutaneous Coronary Intervention (PCI) often requires stent implantation leading to cardiovascular injury and cytokine release. Stent implantation induces cytokines production including TNF\u03b1, Hs-CRP, IL-1\u00df, IL2 receptor, IL6, IL8, and IL10, but their co-release is not extensively established. In 311 PCI patients with Drug-Eluting Stent (DES) implantation, we statistically evaluate the correlation of these cytokines release in various clinical conditions, stent numbers, and medications. We observed that TNF\u03b1 is moderately correlated with IL-1\u00df (r\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.59,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001) in diabetic PCI patients. Similarly, in NSTEMI (Non-ST Segment Elevation) patients, TNF\u03b1 is strongly correlated with both IL-1\u00df (r\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.97,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001) and IL8 (r\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.82,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001). In CAD (Coronary Artery Disease)-diagnosed patients TNF\u03b1 is highly correlated (r\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.84,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0001) with IL8 release but not with IL-1\u00df. In patients with an increased number of stents, Hs-CRP is significantly coupled with IL8\u2009&gt;\u20095\u00a0pg\/ml (t-statistic\u2009=\u20094.5,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). Inflammatory suppressor drugs are correlated as TNF\u03b1 and IL8 are better suppressed by Metoprolol 23.75 (r\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.58,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001) than by Metoprolol 11.87 (r\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.80,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.5306). Increased TNF\u03b1 and IL-1\u00df are better suppressed by the antiplatelet drug Brilinta (r\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.30,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001) but not with Clopidogrel (r\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.87,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). ACI\/ARB Valsartan 80 (r\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.43,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0011) should be preferred over Benazepril 5.0 (r\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.9291,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001) or Olmesartan (r\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.90,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0001). Thus, the co-release of IL-1\u00df, IL8 with TNF\u03b1, or only IL8 with TNF\u03b1 could be a better predictor for the outcome of stent implantation in NSTEMI and CAD-diagnosed AMI patients respectively. Cytokine suppressive medications should be chosen carefully to inhibit further cardiovascular damage.\n                  <\/jats:p>","DOI":"10.1038\/s41598-024-51496-8","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T13:02:40Z","timestamp":1705064560000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Co-release of cytokines after drug-eluting stent implantation in acute myocardial infarction patients with PCI"],"prefix":"10.1038","volume":"14","author":[{"given":"Minying","family":"Wan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit K.","family":"Maiti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,12]]},"reference":[{"issue":"6","key":"51496_CR1","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.bcp.2009.04.029","volume":"78","author":"AH Sprague","year":"2009","unstructured":"Sprague, A. H. & Khalil, R. A. Inflammatory cytokines in vascular dysfunction and vascular disease. Biochem Pharmacol. 78(6), 539\u2013552. https:\/\/doi.org\/10.1016\/j.bcp.2009.04.029 (2009).","journal-title":"Biochem Pharmacol."},{"issue":"4","key":"51496_CR2","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1161\/01.cir.0000054482.38437.13","volume":"107","author":"TA Pearson","year":"2003","unstructured":"Pearson, T. A. et al. American Heart Association guide for improving cardiovascular health at the community level: a statement for public health practitioners, healthcare providers, and health policy makers from the American Heart Association Expert Panel on Population and Prevention Science. Circulation. 107(4), 645\u2013651. https:\/\/doi.org\/10.1161\/01.cir.0000054482.38437.13 (2003).","journal-title":"Circulation."},{"issue":"3","key":"51496_CR3","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1161\/01.cir.0000052939.59093.45","volume":"107","author":"TA Pearson","year":"2003","unstructured":"Pearson, T. A. et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation. 107(3), 499\u2013511. https:\/\/doi.org\/10.1161\/01.cir.0000052939.59093.45 (2003).","journal-title":"Circulation."},{"key":"51496_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13098-017-0304-3","volume":"10","author":"R Marfella","year":"2018","unstructured":"Marfella, R. et al. Effects of incretin treatment on cardiovascular outcomes in diabetic STEMI patients with culprit obstructive and multivessel non-obstructive-coronary-stenosis. Diabetol Metab Syndr. 10, 1. https:\/\/doi.org\/10.1186\/s13098-017-0304-3 (2018).","journal-title":"Diabetol Metab Syndr."},{"issue":"3","key":"51496_CR5","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1111\/dom.13122","volume":"20","author":"R Marfella","year":"2018","unstructured":"Marfella, R. et al. Non-ST-elevation myocardial infarction outcomes in patients with type 2 diabetes with non-obstructive coronary artery stenosis: Effects of incretin treatment. Diabetes Obes Metab. 20(3), 723\u2013729. https:\/\/doi.org\/10.1111\/dom.13122 (2018).","journal-title":"Diabetes Obes Metab."},{"key":"51496_CR6","doi-asserted-by":"publisher","unstructured":"Marfella R, Sardu C, D'Onofrio N, et al. SGLT-2 inhibitors and in-stent restenosis-related events after acute myocardial infarction: an observational study in patients with type 2 diabetes. BMC Med. 21(1), 71. https:\/\/doi.org\/10.1186\/s12916-023-02781-2 (2023).","DOI":"10.1186\/s12916-023-02781-2"},{"issue":"9","key":"51496_CR7","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1016\/j.jacc.2004.11.067","volume":"45","author":"GP Fadini","year":"2005","unstructured":"Fadini, G. P. et al. Circulating endothelial progenitor cells are reduced in peripheral vascular complications of type 2 diabetes mellitus. J Am Coll Cardiol. 45(9), 1449\u20131457. https:\/\/doi.org\/10.1016\/j.jacc.2004.11.067 (2005).","journal-title":"J Am Coll Cardiol."},{"issue":"1","key":"51496_CR8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054514","volume":"8","author":"R Mortuza","year":"2013","unstructured":"Mortuza, R., Chen, S., Feng, B., Sen, S. & Chakrabarti, S. High glucose induced alteration of SIRTs in endothelial cells causes rapid aging in a p300 and FOXO regulated pathway. PLoS One. 8(1), e54514. https:\/\/doi.org\/10.1371\/journal.pone.0054514 (2013).","journal-title":"PLoS One."},{"issue":"4","key":"51496_CR9","doi-asserted-by":"publisher","first-page":"3954","DOI":"10.1016\/j.ijcard.2013.06.053","volume":"168","author":"R Marfella","year":"2013","unstructured":"Marfella, R. et al. Peri-procedural tight glycemic control during early percutaneous coronary intervention up-regulates endothelial progenitor cell level and differentiation during acute ST-elevation myocardial infarction: effects on myocardial salvage. Int J Cardiol. 168(4), 3954\u20133962. https:\/\/doi.org\/10.1016\/j.ijcard.2013.06.053 (2013).","journal-title":"Int J Cardiol."},{"issue":"9","key":"51496_CR10","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1093\/eurheartj\/ehi761","volume":"27","author":"K Sch\u00f6mig","year":"2006","unstructured":"Sch\u00f6mig, K. et al. Interleukin-8 is associated with circulating CD133+ progenitor cells in acute myocardial infarction. Eur Heart J. 27(9), 1032\u20131037. https:\/\/doi.org\/10.1093\/eurheartj\/ehi761 (2006).","journal-title":"Eur Heart J."},{"issue":"3","key":"51496_CR11","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1007\/s11655-009-0236-3","volume":"15","author":"XJ Ma","year":"2009","unstructured":"Ma, X. J., Yin, H. J. & Chen, K. J. Appraisal of the prognosis in patients with acute myocardial infarction treated with primary percutaneous coronary intervention. Chin J Integr Med. 15(3), 236\u2013240. https:\/\/doi.org\/10.1007\/s11655-009-0236-3 (2009).","journal-title":"Chin J Integr Med."},{"issue":"4","key":"51496_CR12","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1007\/s00380-018-1281-7","volume":"34","author":"M Kozel","year":"2019","unstructured":"Kozel, M., Ko\u010dka, V., Lisa, L., Bud\u011b\u0161\u00ednsk\u00fd, T. & Tou\u0161ek, P. Immune-inflammatory response after bioresorbable vascular scaffold implantation in patients with acute myocardial infarction with ST elevation in a long-term perspective. Heart Vessels. 34(4), 557\u2013563. https:\/\/doi.org\/10.1007\/s00380-018-1281-7 (2019).","journal-title":"Heart Vessels."},{"issue":"7","key":"51496_CR13","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1007\/s00380-017-0947-x","volume":"32","author":"H Chibana","year":"2017","unstructured":"Chibana, H. et al. Interleukin-1\u03b2 is associated with coronary endothelial dysfunction in patients with mTOR-inhibitor-eluting stent implantation. Heart Vessels. 32(7), 823\u2013832. https:\/\/doi.org\/10.1007\/s00380-017-0947-x (2017).","journal-title":"Heart Vessels."},{"issue":"2","key":"51496_CR14","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s00380-013-0357-7","volume":"29","author":"I Taguchi","year":"2014","unstructured":"Taguchi, I. et al. The late-phase inflammatory response after drug-eluting stent implantation. Heart Vessels. 29(2), 213\u2013219. https:\/\/doi.org\/10.1007\/s00380-013-0357-7 (2014).","journal-title":"Heart Vessels."},{"issue":"5","key":"51496_CR15","doi-asserted-by":"publisher","first-page":"H2295","DOI":"10.1152\/ajpheart.01116.2006","volume":"292","author":"D B\u00f6se","year":"2007","unstructured":"B\u00f6se, D. et al. Release of TNF-alpha during stent implantation into saphenous vein aortocoronary bypass grafts and its relation to plaque extrusion and restenosis. Am J Physiol Heart Circ Physiol. 292(5), H2295\u2013H2299. https:\/\/doi.org\/10.1152\/ajpheart.01116.2006 (2007).","journal-title":"Am J Physiol Heart Circ Physiol."},{"issue":"4","key":"51496_CR16","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1007\/s11239-010-0466-4","volume":"30","author":"N ElMokhtari","year":"2010","unstructured":"ElMokhtari, N., Zschernitz, S., Sebens, S., Simon-Herrmann, G. & Kr\u00fcger, D. Cardiac release and kinetics of cytokines after elective bare metal coronary stenting. J Thromb Thrombolysis. 30(4), 391\u2013397. https:\/\/doi.org\/10.1007\/s11239-010-0466-4 (2010).","journal-title":"J Thromb Thrombolysis."},{"key":"51496_CR17","doi-asserted-by":"publisher","unstructured":"Sardu C, Trotta MC, Sasso FC, et al. SGLT2-inhibitors effects on the coronary fibrous cap thickness and MACEs in diabetic patients with inducible myocardial ischemia and multi vessels non-obstructive coronary artery stenosis. Cardiovasc Diabetol. 22(1), 80. https:\/\/doi.org\/10.1186\/s12933-023-01814-7 (2023).","DOI":"10.1186\/s12933-023-01814-7"},{"issue":"14","key":"51496_CR18","doi-asserted-by":"publisher","first-page":"1730","DOI":"10.1001\/jama.291.14.1730","volume":"291","author":"T Pischon","year":"2004","unstructured":"Pischon, T. et al. Plasma adiponectin levels and risk of myocardial infarction in men. JAMA. 291(14), 1730\u20131737. https:\/\/doi.org\/10.1001\/jama.291.14.1730 (2004).","journal-title":"JAMA."},{"key":"51496_CR19","doi-asserted-by":"publisher","unstructured":"Sasso FC, Pafundi PC, Marfella R, et al. Adiponectin and insulin resistance are related to restenosis and overall new PCI in subjects with normal glucose tolerance: the prospective AIRE Study. Cardiovasc Diabetol. 18(1), 24. https:\/\/doi.org\/10.1186\/s12933-019-0826-0 (2019).","DOI":"10.1186\/s12933-019-0826-0"},{"key":"51496_CR20","doi-asserted-by":"publisher","unstructured":"Chichareon P, Modolo R, Collet C, et al. Efficacy and Safety of Stents in ST-Segment Elevation Myocardial Infarction. J Am Coll Cardiol. 74(21), 2572\u20132584. https:\/\/doi.org\/10.1016\/j.jacc.2019.09.038 (2019).","DOI":"10.1016\/j.jacc.2019.09.038"},{"issue":"8","key":"51496_CR21","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1177\/0003319716679341","volume":"68","author":"T Miura","year":"2017","unstructured":"Miura, T. et al. Efficacy and Safety of Percutaneous Coronary Intervention for Elderly Patients in the Second-Generation Drug-Eluting Stent Era: The SHINANO Registry. Angiology. 68(8), 688\u2013697. https:\/\/doi.org\/10.1177\/0003319716679341 (2017).","journal-title":"Angiology."},{"key":"51496_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2020.155028","volume":"129","author":"X Li","year":"2020","unstructured":"Li, X. et al. Pro-inflammatory cytokines, oxidative stress and diffuse coronary reocclusions in elderly patients after coronary stenting. Cytokine. 129, 155028. https:\/\/doi.org\/10.1016\/j.cyto.2020.155028 (2020).","journal-title":"Cytokine."},{"issue":"5","key":"51496_CR23","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1002\/iub.2239","volume":"72","author":"X Li","year":"2020","unstructured":"Li, X. et al. Oxidative stress and inflammation: Early predictive indicators of multiple recurrent coronary in-stent chronic total occlusions in elderly patients after coronary stenting. IUBMB Life. 72(5), 1023\u20131033. https:\/\/doi.org\/10.1002\/iub.2239 (2020).","journal-title":"IUBMB Life."},{"issue":"5","key":"51496_CR24","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/S0002-8703(03)00407-1","volume":"146","author":"A Goldberg","year":"2003","unstructured":"Goldberg, A. et al. Diagnostic coronary angiography induces a systemic inflammatory response in patients with stable angina. Am Heart J. 146(5), 819\u2013823. https:\/\/doi.org\/10.1016\/S0002-8703(03)00407-1 (2003).","journal-title":"Am Heart J."},{"issue":"2","key":"51496_CR25","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/s0735-1097(00)01121-9","volume":"37","author":"T Ohtsuka","year":"2001","unstructured":"Ohtsuka, T. et al. Effect of beta-blockers on circulating levels of inflammatory and anti-inflammatory cytokines in patients with dilated cardiomyopathy. J Am Coll Cardiol. 37(2), 412\u2013417. https:\/\/doi.org\/10.1016\/s0735-1097(00)01121-9 (2001).","journal-title":"J Am Coll Cardiol."},{"key":"51496_CR26","doi-asserted-by":"publisher","unstructured":"Grisanti LA, de Lucia C, Thomas TP, et al. Prior \u03b2-blocker treatment decreases leukocyte responsiveness to injury. JCI Insight. 5(9)https:\/\/doi.org\/10.1172\/jci.insight.99485 (2019).","DOI":"10.1172\/jci.insight.99485"},{"key":"51496_CR27","doi-asserted-by":"publisher","unstructured":"Woods EA, Ackman ML, Graham MM, Koshman SL, Boswell RM, Barry AR. Anticoagulant and Antiplatelet Prescribing Patterns for Patients with Atrial Fibrillation after Percutaneous Coronary Intervention. Can J Hosp Pharm. 69(4), 280\u20135. https:\/\/doi.org\/10.4212\/cjhp.v69i4.1574 (2016).","DOI":"10.4212\/cjhp.v69i4.1574"},{"issue":"8","key":"51496_CR28","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1016\/j.jacc.2007.11.035","volume":"51","author":"JM Ruiz-Nodar","year":"2008","unstructured":"Ruiz-Nodar, J. M. et al. Anticoagulant and antiplatelet therapy use in 426 patients with atrial fibrillation undergoing percutaneous coronary intervention and stent implantation implications for bleeding risk and prognosis. J Am Coll Cardiol. 51(8), 818\u2013825. https:\/\/doi.org\/10.1016\/j.jacc.2007.11.035 (2008).","journal-title":"J Am Coll Cardiol."},{"issue":"2","key":"51496_CR29","first-page":"36","volume":"29","author":"RL Noad","year":"2017","unstructured":"Noad, R. L., Hanratty, C. G. & Walsh, S. J. Initial Experience of Bioabsorbable Polymer Everolimus-Eluting Synergy Stents in High-Risk Patients Undergoing Complex Percutaneous Coronary Intervention With Early Discontinuation of Dual-Antiplatelet Therapy. J Invasive Cardiol. 29(2), 36\u201341 (2017).","journal-title":"J Invasive Cardiol."},{"issue":"2","key":"51496_CR30","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1006\/exmp.2002.2450","volume":"73","author":"Q Javed","year":"2002","unstructured":"Javed, Q., Swanson, N., Vohra, H., Thurston, H. & Gershlick, A. H. Tumor necrosis factor-alpha antibody eluting stents reduce vascular smooth muscle cell proliferation in saphenous vein organ culture. Exp Mol Pathol. 73(2), 104\u2013111. https:\/\/doi.org\/10.1006\/exmp.2002.2450 (2002).","journal-title":"Exp Mol Pathol."},{"key":"51496_CR31","doi-asserted-by":"publisher","unstructured":"Di Minno MN, Iervolino S, Peluso R, Scarpa R, Di Minno G, group Cs. Carotid intima-media thickness in psoriatic arthritis: differences between tumor necrosis factor-\u03b1 blockers and traditional disease-modifying antirheumatic drugs. Arterioscler Thromb Vasc Biol. 31(3), 705\u201312. https:\/\/doi.org\/10.1161\/ATVBAHA.110.214585 (2011).","DOI":"10.1161\/ATVBAHA.110.214585"},{"issue":"6","key":"51496_CR32","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1097\/01.fjc.0000250079.46526.38","volume":"48","author":"Q Gu","year":"2006","unstructured":"Gu, Q. et al. Inhibition of TNF-alpha reduces myocardial injury and proinflammatory pathways following ischemia-reperfusion in the dog. J Cardiovasc Pharmacol. 48(6), 320\u2013328. https:\/\/doi.org\/10.1097\/01.fjc.0000250079.46526.38 (2006).","journal-title":"J Cardiovasc Pharmacol."},{"issue":"3","key":"51496_CR33","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1093\/cvr\/cvp241","volume":"84","author":"S Apostolakis","year":"2009","unstructured":"Apostolakis, S., Vogiatzi, K., Amanatidou, V. & Spandidos, D. A. Interleukin 8 and cardiovascular disease. Cardiovasc Res. 84(3), 353\u2013360. https:\/\/doi.org\/10.1093\/cvr\/cvp241 (2009).","journal-title":"Cardiovasc Res."},{"issue":"1","key":"51496_CR34","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/S0022-5223(98)70249-1","volume":"116","author":"EM Boyle","year":"1998","unstructured":"Boyle, E. M. et al. Inhibition of interleukin-8 blocks myocardial ischemia-reperfusion injury. J Thorac Cardiovasc Surg. 116(1), 114\u2013121. https:\/\/doi.org\/10.1016\/S0022-5223(98)70249-1 (1998).","journal-title":"J Thorac Cardiovasc Surg."},{"issue":"6","key":"51496_CR35","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1161\/CIRCULATIONAHA.110.982777","volume":"123","author":"M Kawaguchi","year":"2011","unstructured":"Kawaguchi, M. et al. Inflammasome activation of cardiac fibroblasts is essential for myocardial ischemia\/reperfusion injury. Circulation. 123(6), 594\u2013604. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.110.982777 (2011).","journal-title":"Circulation."},{"key":"51496_CR36","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.589654","volume":"11","author":"W Mai","year":"2020","unstructured":"Mai, W. & Liao, Y. Targeting IL-1\u03b2 in the Treatment of Atherosclerosis. Front Immunol. 11, 589654. https:\/\/doi.org\/10.3389\/fimmu.2020.589654 (2020).","journal-title":"Front Immunol."},{"issue":"12","key":"51496_CR37","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","volume":"377","author":"PM Ridker","year":"2017","unstructured":"Ridker, P. M. et al. Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease. N Engl J Med. 377(12), 1119\u20131131. https:\/\/doi.org\/10.1056\/NEJMoa1707914 (2017).","journal-title":"N Engl J Med."},{"key":"51496_CR38","doi-asserted-by":"publisher","unstructured":"Liberale L, Ministrini S, Carbone F, Camici GG, Montecucco F. Cytokines as therapeutic targets for cardio- and cerebrovascular diseases. Basic Res Cardiol. 116(1), 23. https:\/\/doi.org\/10.1007\/s00395-021-00863-x (2021).","DOI":"10.1007\/s00395-021-00863-x"},{"issue":"8","key":"51496_CR39","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1161\/ATVBAHA.119.311998","volume":"39","author":"H Ait-Oufella","year":"2019","unstructured":"Ait-Oufella, H., Libby, P. & Tedgui, A. Anticytokine Immune Therapy and Atherothrombotic Cardiovascular Risk. Arterioscler Thromb Vasc Biol. 39(8), 1510\u20131519. https:\/\/doi.org\/10.1161\/ATVBAHA.119.311998 (2019).","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"51496_CR40","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.647785","volume":"8","author":"NJ Pluijmert","year":"2021","unstructured":"Pluijmert, N. J., Atsma, D. E. & Quax, P. H. A. Post-ischemic Myocardial Inflammatory Response: A Complex and Dynamic Process Susceptible to Immunomodulatory Therapies. Front Cardiovasc Med. 8, 647785. https:\/\/doi.org\/10.3389\/fcvm.2021.647785 (2021).","journal-title":"Front Cardiovasc Med."},{"key":"51496_CR41","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.746494","volume":"12","author":"M Reina-Couto","year":"2021","unstructured":"Reina-Couto, M. et al. Inflammation in Human Heart Failure: Major Mediators and Therapeutic Targets. Front Physiol. 12, 746494. https:\/\/doi.org\/10.3389\/fphys.2021.746494 (2021).","journal-title":"Front Physiol."},{"key":"51496_CR42","doi-asserted-by":"publisher","unstructured":"Chung ES, Packer M, Lo KH, Fasanmade AA, Willerson JT, Investigators A-TTACHF. Randomized, double-blind, placebo-controlled, pilot trial of infliximab, a chimeric monoclonal antibody to tumor necrosis factor-alpha, in patients with moderate-to-severe heart failure: results of the anti-TNF Therapy Against Congestive Heart Failure (ATTACH) trial. Circulation. 107(25), 3133\u201340. https:\/\/doi.org\/10.1161\/01.CIR.0000077913.60364.D2 (2003).","DOI":"10.1161\/01.CIR.0000077913.60364.D2"},{"issue":"6","key":"51496_CR43","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1007\/s10557-020-07071-0","volume":"34","author":"A Hanna","year":"2020","unstructured":"Hanna, A. & Frangogiannis, N. G. Inflammatory Cytokines and Chemokines as Therapeutic Targets in Heart Failure. Cardiovasc Drugs Ther. 34(6), 849\u2013863. https:\/\/doi.org\/10.1007\/s10557-020-07071-0 (2020).","journal-title":"Cardiovasc Drugs Ther."},{"issue":"2","key":"51496_CR44","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1136\/heartjnl-2012-302482","volume":"100","author":"SJ Head","year":"2014","unstructured":"Head, S. J., Farooq, V., Serruys, P. W. & Kappetein, A. P. The SYNTAX score and its clinical implications. Heart. 100(2), 169\u2013177. https:\/\/doi.org\/10.1136\/heartjnl-2012-302482 (2014).","journal-title":"Heart."},{"key":"51496_CR45","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.ijcard.2015.07.067","volume":"199","author":"YJ Suh","year":"2015","unstructured":"Suh, Y. J. et al. Prognostic value of SYNTAX score based on coronary computed tomography angiography. Int J Cardiol. 199, 460\u2013466. https:\/\/doi.org\/10.1016\/j.ijcard.2015.07.067 (2015).","journal-title":"Int J Cardiol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-51496-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-51496-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-51496-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T13:16:40Z","timestamp":1705065400000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-51496-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,12]]},"references-count":45,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["51496"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-51496-8","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3589435\/v1","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,12]]},"assertion":[{"value":"10 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 January 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1236"}}