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Besides, the development of resistance, traditional therapy has numerous antagonistic effects. Thereby, finding efficient natural alternatives is required. In comparison to albendazole, this study evaluated the impact of pumpkin decoction on\n                    <jats:italic>Trichinella spiralis<\/jats:italic>\n                    in experimentally infected mice. The anthelmintic action of pumpkin decoction (500\u00a0mg\/kg) was determined using\n                    <jats:italic>T. spiralis<\/jats:italic>\n                    infected mice in enteric phase for 5\u00a0days. Pumpkin decoction anthelmintic activity fortified by mixing with honey (1:1). Pumpkin decoction and Pumpkin decoction-honey mixture were evaluated by comprising with reference drug, albendazole (50\u00a0mg\/kg). The\n                    <jats:italic>T. spiralis<\/jats:italic>\n                    adult count was significantly lower in all treated groups, with the pumpkin decoction-honey mixture showing the largest reduction (83.2%) when compared to the infected group (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009\u2264\u20090.001). The intestinal histological changes and the level of COX-2 expression in the intestinal tissue were both significantly reduced in the same group. The pumpkin decoction improved the immune response, as evidenced by a significant decrease in nitric oxide (NO) and tumor necrosis factor (TNF-\u03b1) and a significant increase in the expression of the  transforming growth factor (TGF-1\u03b2) and interleukin-17 (IL-17). The pumpkin decoction's anthelmintic action was facilitated by the TGF-1\u03b2 and IL-17-driven Weep and Sweep mechanism. Both administration of pumpkin decoction beside honey showed the best treatment group that resulted in high infection reduction besides amelioration of  biochemical markers and restoration of histological to normal state. In conclusion, pumpkin decoction is highly effective against\n                    <jats:italic>T. spiralis<\/jats:italic>\n                    which could be a promising alternative herbal drug and the pumpkin decoction effect was higher in the case of combination with honey.\n                  <\/jats:p>","DOI":"10.1038\/s41598-024-51616-4","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T23:39:50Z","timestamp":1705534790000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["RETRACTED ARTICLE: Pumpkin seeds (Cucurbita pepo subsp. ovifera) decoction promotes Trichinella spiralis expulsion during intestinal phase via \u201cWeep and Sweep\u201d mechanism"],"prefix":"10.1038","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0474-6152","authenticated-orcid":false,"given":"Aml S.","family":"Saleh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samah A.","family":"El-Newary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walaa A.","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelbaset M.","family":"Elgamal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona A.","family":"Farah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,18]]},"reference":[{"key":"51616_CR1","doi-asserted-by":"publisher","first-page":"e12393","DOI":"10.1111\/pim.12393","volume":"39","author":"JL Mu\u00f1oz-Carrillo","year":"2021","unstructured":"Mu\u00f1oz-Carrillo, J. 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