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In this work, we investigated the antifungal activity of silver nanoparticles (AgNPs) biosynthesized from <jats:italic>Rhazya stricta<\/jats:italic> aqueous extract against several plant pathogenic fungi. UV\u2013visible spectroscopy, Zeta potential analysis, Fourier-transform infrared spectroscopy (FTIR), and transmitted electron microscopy (TEM) were used to analyze the biosynthesized AgNPs. <jats:italic>Drechslera halodes, Drechslera tetramera, Macrophomina phaseolina, Alternaria alternata,<\/jats:italic> and <jats:italic>Curvularia australiensis<\/jats:italic> were tested for their potential antifungal activity. Surface Plasmon Resonance (SPR) of Aq. AgNPs and Alkaline Aq. AgNPs was observed at 405 nm and 415 nm, respectively. FTIR analysis indicated hydroxyl, nitrile, amine, and ketone functional groups. Aq. AgNPs and Alka-line Aq. AgNPs had velocities of \u2212\u00a027.7 mV and \u2212\u00a037.9 mV and sizes of 21\u201390 nm and 7.2\u201325.3 nm, respectively, according to zeta potential studies and TEM. The antifungal examination revealed that all species' mycelial development was significantly inhibited, accompanied by severe ultra-structural alterations. Among all treatments, Aq. AgNPs were the most effective fungicide. <jats:italic>M. phaseolina<\/jats:italic> was statistically the most resistant, whereas <jats:italic>A. alternata<\/jats:italic> was the most vulnerable. To the best of our knowledge, this is the first report on <jats:italic>R. stricta'<\/jats:italic>s antifungal activity against these species.<\/jats:p>","DOI":"10.1038\/s41598-024-51855-5","type":"journal-article","created":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T13:01:57Z","timestamp":1705237317000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Silver nanoparticles improve the fungicidal properties of Rhazya stricta decne aqueous extract against plant pathogens"],"prefix":"10.1038","volume":"14","author":[{"given":"Sarah A.","family":"Al-Sahli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3629-5755","authenticated-orcid":false,"given":"Fatimah","family":"Al-Otibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raedah I.","family":"Alharbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Musarat","family":"Amina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nawal M.","family":"Al Musayeib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,14]]},"reference":[{"key":"51855_CR1","doi-asserted-by":"publisher","first-page":"1125106","DOI":"10.3389\/fnut.2023.1125106","volume":"10","author":"A Mueed","year":"2023","unstructured":"Mueed, A. et al. 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