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We aimed to investigate the aortic, lower limb peripheral arterial stiffness and their associations with knee OA. Patients with primary knee OA and matched non-OA controls were prospectively enrolled from two medical centers in China. The carotid-femoral pulse wave velocity (cfPWV) and femoral-ankle pulse wave velocity (faPWV) were measured using a novel ultrasound technique. A total of 238 participants (including 128 patients with knee OA and 110 controls) were included. In OA patients, cfPWV was significantly higher than that of non-OA controls (9.40\u2009\u00b1\u20091.92 vs 8.25\u2009\u00b1\u20091.26\u00a0m\/s, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). However, faPWV measurements in OA patients (12.10\u2009\u00b1\u20092.09\u00a0m\/s) showed no significant difference compared with that of the controls (11.67\u2009\u00b1\u20092.52\u00a0m\/s, <jats:italic>P<\/jats:italic>\u2009=\u20090.130). Multiple regression analysis revealed that cfPWV was independently associated with knee OA (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001) after adjusting for the confounding factors including age, gender, smoking, mean blood pressure, body mass index, heart rate, high-sensitivity C-reactive protein and lipids profiles. In contrast, faPWV did not show independent association with knee OA (<jats:italic>P<\/jats:italic>\u2009=\u20090.372) when after adjusting for confounding factors. In addition, Spearman\u2019s correlation analysis showed cfPWV had a significant correlation with Kellgren-Lawrence score (r<jats:sub>s<\/jats:sub>\u2009=\u20090.2333, <jats:italic>P<\/jats:italic>\u2009=\u20090.008), but no correlation was founded between faPWV with Kellgren-Lawrence score (r<jats:sub>s<\/jats:sub>\u2009=\u20090.1624, <jats:italic>P<\/jats:italic>\u2009=\u20090.067) in OA patients. This study demonstrated that stiffening of aorta, but not lower limb arteries, was independently associated with knee OA. Our findings may call for further implementation of routine aortic stiffness assessments so as to evaluate cardiovascular risk in patients with OA.<\/jats:p>","DOI":"10.1038\/s41598-024-52097-1","type":"journal-article","created":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T08:05:18Z","timestamp":1705392318000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Assessment of aortic and peripheral arterial stiffness in patients with knee osteoarthritis by ultrasound Doppler derived pulse wave velocity"],"prefix":"10.1038","volume":"14","author":[{"given":"Yong","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-xin","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-li","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-peng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,16]]},"reference":[{"key":"52097_CR1","doi-asserted-by":"publisher","first-page":"1025063","DOI":"10.3389\/fcvm.2022.1025063","volume":"9","author":"Z Wang","year":"2022","unstructured":"Wang, Z. et al. 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