{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:55:40Z","timestamp":1780376140264,"version":"3.54.1"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T00:00:00Z","timestamp":1705881600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T00:00:00Z","timestamp":1705881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The consumption of bovine milk and its derivatives is associated with inflammation, gastrointestinal disorders and the development of diseases in humans. Most studies related to milk effects are based on either clinal trials or experimental models such as mice and cell cultures. In this study we present the nematode\n                    <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                    as an alternative model to evaluate the effects of milk on oxidative stress in other animal models. The toxicological effect of 20% milk exposure for 8\u00a0h on\n                    <jats:italic>C. elegans<\/jats:italic>\n                    was evaluated by progeny quantification, body size and pharyngeal pumping rate. Treating the worms with milk did not affect the worms brood size but interfered with their fecundity by delaying the average number of eggs in the first day of oviposition when compared to the control group. The size of worms treated with milk were significantly smaller compared to control. The pharyngeal pumping rate of milk-treated animals was not significantly different compared to untreated animals. Taking together, the results suggest that 20% milk treatment is not toxic for the worms but induces a minor delay achieving its adulthood and therefore its reproduction period. Milk exposure did not reduce the worms\u2019 survival under stress conditions and increase endogenous ROS levels. This study contributes to characterize the effects of milk exposure on the\n                    <jats:italic>C. elegans<\/jats:italic>\n                    nematode.\n                  <\/jats:p>","DOI":"10.1038\/s41598-024-52254-6","type":"journal-article","created":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T11:02:16Z","timestamp":1705921336000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of milk exposure on the redox profile of Caenorhabditis elegans"],"prefix":"10.1038","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3685-289X","authenticated-orcid":false,"given":"Ingrid La\u00edse Silvestre","family":"de Oliveira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4584-6961","authenticated-orcid":false,"given":"Giovanna Melo Martins","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3118-4781","authenticated-orcid":false,"given":"Cesar Orlando Mu\u00f1oz","family":"Cadavid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0230-3446","authenticated-orcid":false,"given":"Danielle Cavalcanti","family":"Sales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4394-7777","authenticated-orcid":false,"given":"Katya","family":"Anaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6092-6142","authenticated-orcid":false,"given":"Riva","family":"de Paula Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2835-4156","authenticated-orcid":false,"given":"Adriano Henrique","family":"do Nascimento Rangel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,22]]},"reference":[{"issue":"1","key":"52254_CR1","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3945\/ajcn.2009.28468","volume":"91","author":"MB Zemel","year":"2010","unstructured":"Zemel, M. B., Sun, X., Sobhani, T. & Wilson, B. Effects of dairy compared with soy on oxidative and inflammatory stress in overweight and obese subjects. Am. J. Clin. Nutr. 91(1), 16\u201322. https:\/\/doi.org\/10.3945\/ajcn.2009.28468 (2010).","journal-title":"Am. J. Clin. Nutr."},{"issue":"2","key":"52254_CR2","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1590\/1678-457X.001910.1590\/1678-457X.0019","volume":"36","author":"AHN Rangel","year":"2016","unstructured":"Rangel, A. H. N. et al. Lactose intolerance and cow\u2019s milk protein allergy. Food Sci. Technol. 36(2), 179\u2013187. https:\/\/doi.org\/10.1590\/1678-457X.001910.1590\/1678-457X.0019 (2016).","journal-title":"Food Sci. Technol."},{"issue":"2","key":"52254_CR3","doi-asserted-by":"publisher","first-page":"422","DOI":"10.3945\/ajcn.111.013342","volume":"94","author":"RA Stancliffe","year":"2011","unstructured":"Stancliffe, R. A., Thorpe, T. & Zemel, M. B. Dairy attenuates oxidative and inflammatory stress in metabolic syndrome. Am. J. Clin. Nutr. 94(2), 422\u2013430. https:\/\/doi.org\/10.3945\/ajcn.111.013342 (2011).","journal-title":"Am. J. Clin. Nutr."},{"issue":"1","key":"52254_CR4","doi-asserted-by":"publisher","first-page":"12","DOI":"10.14202\/vetworld.2019.12-33","volume":"12","author":"IT Khan","year":"2019","unstructured":"Khan, I. T. et al. The antioxidant components of milk and their role in processing, ripening, and storage: Functional food. Vet. World 12(1), 12\u201333. https:\/\/doi.org\/10.14202\/vetworld.2019.12-33 (2019).","journal-title":"Vet. World"},{"issue":"11","key":"52254_CR5","doi-asserted-by":"publisher","first-page":"8499","DOI":"10.3168\/jds.2015-10626","volume":"99","author":"S Awad","year":"2016","unstructured":"Awad, S. et al. Antioxidant activity of milk protein hydrolysate in alloxan-induced diabetic rats. J. 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