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To accomplish this, we reviewed the medical records of patients with ROP who were examined at the ROP Clinic of the Tokyo Women's Medical University Hospital. We studied 43 eyes of 23 children with ROP and 67 eyes of 36 control children without any fundus abnormalities. The optical coherence tomography angiographic (OCTA) <jats:italic>en face<\/jats:italic> images were used to measure the size and location of the foveal avascular zone (FAZ), and cross-sectional OCT images to measure the central retinal thickness (CRT). Our results showed that the size of the FAZ was significantly smaller in the ROP group (0.200\u2009\u00b1\u20090.142 mm<jats:sup>2<\/jats:sup>) than in the control group (0.319\u2009\u00b1\u20090.085 mm<jats:sup>2<\/jats:sup>; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). The CRT was significantly thicker in the ROP group (228\u2009\u00b1\u200930\u00a0\u00b5m) than in the control group (189\u2009\u00b1\u200913\u00a0\u00b5m; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). The mean length of the foveal bulge was not significantly different between the two groups. The actual distance of the misalignment between the center of the FAZ and the center of the photoreceptors was significantly greater in the ROP group (50.4\u2009\u00b1\u200929.5\u00a0\u00b5m) than in the control group (39.6\u2009\u00b1\u200921.9\u00a0\u00b5m; P\u2009=\u20090.001). The correlations between the actual distance of misalignment and the size of the FAZ, CRT, and length of the foveal bulge in both groups were not significant. Despite the significant misalignment in eyes with a history of ROP, the center of the foveal photoreceptors was consistently located within the narrow FAZ which indicates that the development of the FAZ and photoreceptor formation are interrelated.<\/jats:p>","DOI":"10.1038\/s41598-024-52407-7","type":"journal-article","created":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T14:02:32Z","timestamp":1706018552000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Misalignment of center of foveal avascular zone and center of photoreceptors in eyes with history of retinopathy of prematurity"],"prefix":"10.1038","volume":"14","author":[{"given":"Ichiro","family":"Maruko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotaro","family":"Irie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiji","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manami","family":"Takagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Iida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,23]]},"reference":[{"key":"52407_CR1","first-page":"225","volume":"103","author":"BT Smith","year":"2005","unstructured":"Smith, B. 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