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Here, we studied SRS-T impacts on left Vim dynamic functional connectivity (dFC,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200923 ET patients scanned before and 1\u00a0year after intervention), and on surface-based morphometric brain features (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200934 patients, including those from dFC analysis). In matched healthy controls (HCs), three dFC states were extracted from resting-state functional MRI data. In ET patients, state 1 spatial stability increased upon SRS-T (\n                    <jats:italic>F<\/jats:italic>\n                    <jats:sub>1,22<\/jats:sub>\n                    \u2009=\u200919.13,\u00a0\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.004). More frequent expression of state 3 over state 1 before SRS-T correlated with greater clinical recovery in a way that depended on the MR signature volume (\n                    <jats:italic>t<\/jats:italic>\n                    <jats:sub>6<\/jats:sub>\n                    \u2009=\u20094.6,\u00a0\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.004). Lower pre-intervention spatial variability in state 3 expression also did (\n                    <jats:italic>t<\/jats:italic>\n                    <jats:sub>6<\/jats:sub>\n                    \u2009=\u2009\u2212\u20094.24,\u00a0\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.005) and interacted with the presence of familial ET so that these patients improved less (\n                    <jats:italic>t<\/jats:italic>\n                    <jats:sub>6<\/jats:sub>\n                    \u2009=\u20094.14,\u00a0\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.006). ET morphometric profiles showed significantly lower similarity to HCs in 13 regions upon SRS-T (\n                    <jats:italic>z<\/jats:italic>\n                    \u2009\u2264\u2009\u2212\u20093.66,\u00a0\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2264\u20090.022), and a joint analysis revealed that before thalamotomy, morphometric similarity and states 2\/3 mean spatial similarity to HCs were anticorrelated, a relationship that disappeared upon SRS-T (\n                    <jats:italic>z<\/jats:italic>\n                    \u2009\u2265\u20094.39,\u00a0\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Our results show that left Vim functional dynamics directly relates to upper limb tremor lowering upon intervention, while morphometry instead has a supporting role in reshaping such dynamics.\n                  <\/jats:p>","DOI":"10.1038\/s41598-024-52410-y","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T11:02:32Z","timestamp":1706698952000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Dynamic functional changes upon thalamotomy in essential tremor depend on baseline brain morphometry"],"prefix":"10.1038","volume":"14","author":[{"given":"Thomas A. 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Essential tremor. Nat. Rev. Dis. Primers. 7, 83 (2021).","journal-title":"Nat. Rev. Dis. Primers."},{"key":"52410_CR2","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1056\/NEJMcp1707928","volume":"378","author":"D Haubenberger","year":"2018","unstructured":"Haubenberger, D. & Hallett, M. Essential tremor. N. Engl. J. Med. 378, 1802\u20131810 (2018).","journal-title":"N. Engl. J. Med."},{"key":"52410_CR3","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1038\/nrneurol.2011.44","volume":"7","author":"F Bermejo-Pareja","year":"2011","unstructured":"Bermejo-Pareja, F. Essential tremor\u2014A neurodegenerative disorder associated with cognitive defects?. Nat. Rev. Neurol. 7, 273\u2013282 (2011).","journal-title":"Nat. Rev. Neurol."},{"key":"52410_CR4","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.parkreldis.2019.02.038","volume":"63","author":"ED Louis","year":"2019","unstructured":"Louis, E. D., Joyce, J. L. & Cosentino, S. 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