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Nonetheless, the scientific evidence necessary to prove the herb\u2019s doctrine has not yet been revealed. Verbascoside-rich extracts of the herbal medicine\n                    <jats:italic>A. ebracteatus<\/jats:italic>\n                    Vahl., were therefore prepared. The extracts and verbascoside were examined for their wound healing abilities using a scratch assay with fibroblasts. The anti-inflammatory effect suppressing MMP-9 was assessed in cocultures of keratinocyte (HaCaT cells) and fibroblasts. The extracts significantly improved wound healing compared with the control (p\u2009&lt;\u20090.001). The wound healing effect of the extracts significantly (p\u2009&lt;\u20090.01) increased with increasing verbascoside content. It should be noted that the extract was significantly (p\u2009&lt;\u20090.05) better than verbascoside at the same test concentration. The extracts were capable of protecting cocultures of HaCaT cells and fibroblasts from photodamage. The extracts significantly (p\u2009&lt;\u20090.001) suppressed cellular MMP-9 secretion following UV exposure, showing a better effect than that of verbascoside (p\u2009&lt;\u20090.01).\n                    <jats:italic>A. ebracteatus<\/jats:italic>\n                    extract is promising for wound healing and photoprotection, and a prominent source of verbascoside. Verbascoside-rich\n                    <jats:italic>A. ebracteatus<\/jats:italic>\n                    could be utilized for the development of innovative skin-care products.\n                  <\/jats:p>","DOI":"10.1038\/s41598-024-52511-8","type":"journal-article","created":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T08:02:22Z","timestamp":1705910542000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Wound healing and photoprotection properties of Acanthus ebracteatus Vahl. extracts standardized in verbascoside"],"prefix":"10.1038","volume":"14","author":[{"given":"Mayuree","family":"Kanlayavattanakul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattaka","family":"Khongkow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nattaya","family":"Lourith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,22]]},"reference":[{"key":"52511_CR1","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.jtcme.2017.06.012","volume":"9","author":"SR Varma","year":"2019","unstructured":"Varma, S. 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