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Additionally, factors influencing long-term success were identified. Teeth treated during 2011\u20132022 in a private clinic were studied with clinical\/radiographic follow-ups. Data included patient demographics, tooth specifics, and treatment details. Outcomes were classified as success\/failure based on clinical\/radiographic findings, with tooth functionality determining the survival rate. Encompassing 1149 patients and 1257 VPT-treated teeth, the average monitoring period was 42.2\u00a0months. Overall VPTs\u2019 survival and success rates were 99.1% and 91.6%, respectively. Success rates for 768 direct pulp cappings, 217 miniature pulpotomies, and 272 full pulpotomies were 91.9%, 92.6%, and 90.1%, respectively (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&gt;\u20090.05). Influencing factors included symptomatic irreversible pulpitis (SIP; HR 1.974, 95% CI 1.242\u20133.137;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.004), radiographic signs of apical periodontitis (AP; HR 2.983, 95% CI 1.961\u20134.540;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001), restoration type (HR 2.263, 95%CI 1.423\u20133.600;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.001), and restoration surfaces (HR 1.401, 95%CI 1.034\u20131.899;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.030). This study concludes that VPT techniques consistently exhibit high long-term success\/survival rates in treating carious pulp exposures. Critical predictors include initial clinical signs of SIP\/AP, caries extent, and use of composite restorations.\n                  <\/jats:p>","DOI":"10.1038\/s41598-024-52654-8","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T09:15:26Z","timestamp":1706087726000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Outcomes and predictive factors of vital pulp therapy in a large-scale retrospective cohort study over 10\u00a0years"],"prefix":"10.1038","volume":"14","author":[{"given":"Saeed","family":"Asgary","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyla","family":"Roghanizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Jafar","family":"Eghbal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Akbarzadeh Baghban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Aminoshariae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Nosrat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,24]]},"reference":[{"key":"52654_CR1","doi-asserted-by":"publisher","first-page":"6743","DOI":"10.1007\/s00784-021-03960-2","volume":"25","author":"DJX Leong","year":"2021","unstructured":"Leong, D. 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