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The use of insect repellents is one of precautionary measures used to mitigate the risk of these diseases in humans by reducing mosquito biting. Nepetalactone, a potent natural insect repellent primarily found in catnip (\n                    <jats:italic>Nepeta cataria<\/jats:italic>\n                    ) essential oil, has emerged as a promising candidate for mosquito repellence. Here, we evaluated the potential of catnip essential oil (&gt;\u200995% nepetalactone) for use as a mosquito repellent. Using a Y-tube olfactometer and human hands as an attractant, we analysed the effectiveness of catnip oil at repelling the mosquito species\n                    <jats:italic>Aedes aegypti<\/jats:italic>\n                    . We tested a range of dilutions of catnip essential oil and found that concentrations as low as 2% were effective at repelling\u2009&gt;\u200970% of mosquitoes for between one and four hours after repellent application. These findings suggest that nepetalactone could potentially be used as a natural, effective alternative to synthetic mosquito repellents, thereby offering protection against vector-borne diseases.\n                  <\/jats:p>","DOI":"10.1038\/s41598-024-52715-y","type":"journal-article","created":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T02:02:18Z","timestamp":1706320938000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Evaluating repellence properties of catnip essential oil against the mosquito species Aedes aegypti using a Y-tube olfactometer"],"prefix":"10.1038","volume":"14","author":[{"given":"Charles","family":"Batume","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan Mugeni","family":"Mulongo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Ludlow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Ssebaale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Randerson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Pickett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan M.","family":"Mukisa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Scofield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,27]]},"reference":[{"key":"52715_CR1","unstructured":"World Health Organization. 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Parasite Vectors 2014(3), 173 (2014).","journal-title":"Parasite Vectors"},{"key":"52715_CR4","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.ejphar.2018.02.033","volume":"825","author":"S Legeay","year":"2018","unstructured":"Legeay, S., Clere, N., Apaire-Marchais, V., Faure, S. & Lapied, B. Unusual modes of action of the repellent DEET in insects highlight some human side effects. Eur. J. Pharmacol. 825, 92\u201398 (2018).","journal-title":"Eur. J. Pharmacol."},{"issue":"7","key":"52715_CR5","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/1741-7007-7-47","volume":"5","author":"V Corbel","year":"2009","unstructured":"Corbel, V. et al. Evidence for inhibition of cholinesterases in insect and mammalian nervous systems by the insect repellent deet. BMC Biol. 5(7), 47 (2009).","journal-title":"BMC Biol."},{"issue":"1","key":"52715_CR6","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1186\/s12936-020-03217-5","volume":"19","author":"M Shelomi","year":"2020","unstructured":"Shelomi, M. Who\u2019s afraid of DEET? Fearmongering in papers on botanical repellents. Malar. J. 19(1), 146 (2020).","journal-title":"Malar. J."},{"issue":"1","key":"52715_CR7","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1006\/faat.1995.1043","volume":"25","author":"S Selim","year":"1995","unstructured":"Selim, S., Hartnagel, R. E. Jr., Osimitz, T. G., Gabriel, K. L. & Schoenig, G. P. Absorption, metabolism, and excretion of N, N-diethyl-m-toluamide following dermal application to human volunteers. Fundam. Appl. Toxicol. 25(1), 95\u2013100 (1995).","journal-title":"Fundam. Appl. 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