{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T16:35:28Z","timestamp":1793291728096,"version":"4.5.0"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Seborrheic dermatitis (SD) affects 2\u20135% of the global population, with imbalances in the skin microbiome implicated in its development. This study assessed the impact of an oily suspension containing <jats:italic>Lactobacillus crispatus<\/jats:italic> P17631 and <jats:italic>Lacticaseibacillus paracasei<\/jats:italic> I1688 (termed EUTOPLAC) on SD symptoms and the skin mycobiome-bacteriome modulation. 25 SD patients were treated with EUTOPLAC for a week. Symptom severity and skin mycobiome-bacteriome changes were measured at the start of the treatment (T0), after seven days (T8), and three weeks post-treatment (T28). Results indicated symptom improvement post-EUTOPLAC, with notable reductions in the <jats:italic>Malassezia<\/jats:italic> genus. Concurrently, bacterial shifts were observed, including a decrease in <jats:italic>Staphylococcus<\/jats:italic> and an increase in <jats:italic>Lactobacillus<\/jats:italic> and <jats:italic>Lacticaseibacillus<\/jats:italic>. Network analysis highlighted post-EUTOPLAC instability in fungal and bacterial interactions, with increased negative correlations between <jats:italic>Malassezia<\/jats:italic> and <jats:italic>Lactobacillus<\/jats:italic> and <jats:italic>Lacticaseibacillus<\/jats:italic> genera. The study suggests EUTOPLAC's potential as a targeted SD treatment, reducing symptoms and modulating the mycobiome-bacteriome composition.<\/jats:p>","DOI":"10.1038\/s41598-024-53016-0","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T17:02:33Z","timestamp":1706806953000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Modulating the skin mycobiome-bacteriome and treating seborrheic dermatitis with a probiotic-enriched oily suspension"],"prefix":"10.1038","volume":"14","author":[{"given":"Mauro","family":"Truglio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Sivori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Cavallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elva","family":"Abril","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"Licursi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Fabrizio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Cardinali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Pignatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Toma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floriana","family":"Valensise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Cristaudo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulvia","family":"Pimpinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enea Gino","family":"Di Domenico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,1]]},"reference":[{"key":"53016_CR1","doi-asserted-by":"publisher","unstructured":"Dessinioti, C. & Katsambas, A. Seborrheic dermatitis: etiology, risk factors, and treatments: facts and controversies. Clin. Dermatol. 31, 343\u2013351; https:\/\/doi.org\/10.1016\/j.clindermatol.2013.01.001 (2013).","DOI":"10.1016\/j.clindermatol.2013.01.001"},{"key":"53016_CR2","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1080\/09546634.2018.1473554","volume":"30","author":"LJ Borda","year":"2019","unstructured":"Borda, L. J., Perper, M. & Keri, J. E. Treatment of seborrheic dermatitis: a comprehensive review. J. Dermatolog. Treat. 30, 158\u2013169 (2019).","journal-title":"J. Dermatolog. Treat."},{"key":"53016_CR3","doi-asserted-by":"publisher","unstructured":"Borda, L. J. & Wikramanayake, T. C. Seborrheic Dermatitis, and Dandruff: A Comprehensive Review. J. Clin. Investig. Dermatol. 3, https:\/\/doi.org\/10.13188\/2373-1044.1000019 (2015).","DOI":"10.13188\/2373-1044.1000019"},{"key":"53016_CR4","doi-asserted-by":"publisher","unstructured":"Tao, R., Li, R. & Wang, R. Skin microbiome alterations in seborrheic dermatitis and dandruff: A systematic review. Exp. Dermatol. 30, 1546\u20131553; https:\/\/doi.org\/10.1111\/exd.14450 (2021).","DOI":"10.1111\/exd.14450"},{"key":"53016_CR5","doi-asserted-by":"publisher","unstructured":"Lunjani, N., Ahearn-Ford, S., Dube, F. S., Hlela, C. & O'Mahony, L. Mechanisms of microbe-immune system dialogue within the skin. Genes Immun. 22, 276\u2013288; https:\/\/doi.org\/10.1038\/s41435-021-00133-9 (2021).","DOI":"10.1038\/s41435-021-00133-9"},{"key":"53016_CR6","doi-asserted-by":"publisher","unstructured":"Belkaid, Y. & Segre, J. A. Dialogue between skin microbiota and immunity. Science. 346, 954\u2013959; https:\/\/doi.org\/10.1126\/science.1260144 (2014).","DOI":"10.1126\/science.1260144"},{"key":"53016_CR7","doi-asserted-by":"publisher","unstructured":"Saunte, D.M.L., Gaitanis, G., Hay, R.J. Malassezia-Associated Skin Diseases, the Use of Diagnostics and Treatment. Front Cell Infect. Microbiol. 20, 10:112. https:\/\/doi.org\/10.3389\/fcimb.2020.00112. (2020).","DOI":"10.3389\/fcimb.2020.00112"},{"key":"53016_CR8","doi-asserted-by":"crossref","unstructured":"Saxena, R., Mittal, P., Clavaud, C., Dhakan D. B., Hegdeet, P. al. Comparison of healthy and dandruff scalp microbiome reveals the role of commensals in scalp health. Front. Cell Infect. Microbiol. 8, 346 (2018).","DOI":"10.3389\/fcimb.2018.00346"},{"key":"53016_CR9","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/j.jaad.2003.12.034","volume":"51","author":"AK Gupta","year":"2004","unstructured":"Gupta, A. K., Batra, R., Bluhm, R., Boekhout, T. & Dawson, T. L. Skin diseases associated with Malassezia species. J. Am. Acad. Dermatol. 51, 785\u2013798 (2004).","journal-title":"J. Am. Acad. Dermatol."},{"key":"53016_CR10","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1038\/jid.2013.92","volume":"133","author":"P Magiatis","year":"2013","unstructured":"Magiatis, P. et al. Malassezia yeasts produce a collection of exceptionally potent activators of the Ah (dioxin) receptor detected in diseased human skin. J. Invest. Dermatol. 133, 2023\u20132030 (2013).","journal-title":"J. Invest. Dermatol."},{"key":"53016_CR11","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1007\/s00449-020-02333-5","volume":"44","author":"Q Lin","year":"2020","unstructured":"Lin, Q. et al. Malassezia and Staphylococcus dominate scalp microbiome for seborrheic dermatitis. Bioprocess Biosyst. Eng. 44, 965\u2013975 (2020).","journal-title":"Bioprocess Biosyst. Eng."},{"key":"53016_CR12","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1111\/exd.13293","volume":"26","author":"T Park","year":"2017","unstructured":"Park, T. et al. Collapse of human scalp microbiome network in dandruff and seborrhoeic dermatitis. Exp. Dermatol. 26, 835\u2013838 (2017).","journal-title":"Exp. Dermatol."},{"key":"53016_CR13","doi-asserted-by":"crossref","unstructured":"Grimshaw, S. G., Smith, A. M., Arnold, D. S., Xu, E., Hoptroffet, M. al. The diversity and abundance of fungi and bacteria on the healthy and dandruff affected human scalp. PLoS One. 14, e0225796 (2019).","DOI":"10.1371\/journal.pone.0225796"},{"key":"53016_CR14","doi-asserted-by":"publisher","first-page":"157","DOI":"10.3389\/fcimb.2016.00157","volume":"6","author":"RC Soares","year":"2016","unstructured":"Soares, R. C. et al. Dysbiotic bacterial and fungal communities not restricted to clinically affected skin sites in dandruff. Front. Cell Infect. Microbiol. 6, 157 (2016).","journal-title":"Front. Cell Infect. Microbiol."},{"key":"53016_CR15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117921","volume":"10","author":"RC Soares","year":"2015","unstructured":"Soares, R. C., Zani, M. B., Arruda, A. C., de Arruda, L. H. F. & Campos Paulino, L. Malassezia intra-specific diversity and potentially new species in the skin microbiota from Brazilian healthy subjects and seborrheic dermatitis patients. PLoS One 10, e0117921 (2015).","journal-title":"PLoS One"},{"key":"53016_CR16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032847","volume":"7","author":"HK Park","year":"2012","unstructured":"Park, H. K. et al. Characterization of the fungal microbiota (mycobiome) in healthy and dandruff-afflicted human scalps. PLoS One. 7, e32847 (2012).","journal-title":"PLoS One."},{"key":"53016_CR17","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1111\/exd.12684","volume":"24","author":"L Wang","year":"2015","unstructured":"Wang, L. et al. Characterization of the major bacterial-fungal populations colonizing dandruff scalps in Shanghai, China, shows microbial disequilibrium. Exp. Dermatol. 24, 398\u2013400 (2015).","journal-title":"Exp. Dermatol."},{"key":"53016_CR18","doi-asserted-by":"publisher","unstructured":"Wang, L., Yu, T., Zhu, Y., Luo, Y., Dong, F., et al. Amplicon-based sequencing and co-occurence network analysis reveals notable differences of microbial community structure in healthy and dandruff scalps. BMC Genomics. 23, 312; https:\/\/doi.org\/10.1186\/s12864-022-08534-4 (2022).","DOI":"10.1186\/s12864-022-08534-4"},{"key":"53016_CR19","doi-asserted-by":"publisher","unstructured":"Habeebuddin, M., Karnati, R. K., Shiroorkar, P. N., Nagaraja, S., Asdaq, S. M. B., et al. Topical probiotics: more than a skin deep. Pharmaceutics. 14, 557; https:\/\/doi.org\/10.3390\/pharmaceutics14030557 (2022).","DOI":"10.3390\/pharmaceutics14030557"},{"key":"53016_CR20","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s13555-020-00476-7","volume":"11","author":"K Fran\u00e7a","year":"2021","unstructured":"Fran\u00e7a, K. Topical probiotics in dermatological therapy and skincare: a concise review. Dermatol. Ther. 11, 71\u201377 (2021).","journal-title":"Dermatol. Ther."},{"key":"53016_CR21","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1126\/science.aad2602","volume":"350","author":"KZ Coyte","year":"2015","unstructured":"Coyte, K. Z., Schluter, J. & Foster, K. R. The ecology of the microbiome: networks, competition, and stability. Science. 350, 663\u2013666 (2015).","journal-title":"Science."},{"key":"53016_CR22","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1186\/s40168-020-00874-1","volume":"8","author":"MHY Leung","year":"2020","unstructured":"Leung, M. H. Y. et al. Changes of the human skin microbiota upon chronic exposure to polycyclic aromatic hydrocarbon pollutants. Microbiome. 8, 100 (2020).","journal-title":"Microbiome."},{"key":"53016_CR23","doi-asserted-by":"publisher","unstructured":"Di Domenico, E. G., Oliva, A. & Guembe, M. The Current Knowledge on the Pathogenesis of Tissue and Medical Device-Related Biofilm Infections. Microorganisms. 10, 1259; https:\/\/doi.org\/10.3390\/microorganisms10071259 (2022).u","DOI":"10.3390\/microorganisms10071259"},{"key":"53016_CR24","doi-asserted-by":"publisher","unstructured":"Polak, K., Jobb\u00e1gy, A., Muszy\u0144ski, T., Wojciechowska, K., Fr\u0105tczak, A. et al. Microbiome Modulation as a Therapeutic Approach in Chronic Skin Diseases. Biomedicines. 9, 1436; https:\/\/doi.org\/10.3390\/biomedicines9101436 (2021).","DOI":"10.3390\/biomedicines9101436"},{"key":"53016_CR25","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1111\/j.1468-3083.2007.02508.x","volume":"22","author":"A Gu\u00e9niche","year":"2008","unstructured":"Gu\u00e9niche, A. et al. Vitreoscilla filiformis biomass improves seborrheic dermatitis. J. Eur. Acad Dermatol. Venereol. 22, 1014\u20131015 (2008).","journal-title":"J. Eur. Acad Dermatol. Venereol."},{"key":"53016_CR26","doi-asserted-by":"publisher","first-page":"671","DOI":"10.3920\/BM2016.0144","volume":"8","author":"P Reygagne","year":"2017","unstructured":"Reygagne, P. et al. The positive benefit of Lactobacillus paracasei NCC2461 ST11 in healthy volunteers with moderate to severe dandruff. Benef. Microbes 8, 671\u2013680 (2017).","journal-title":"Benef. Microbes"},{"key":"53016_CR27","unstructured":"Castiel, I. & Gueniche, A. Cosmetic and Dermatological Use of Probiotic Lactobacillus paracasei Microorganisms for the Treatment of Greasy Scalp Disorders (Kosmetische und Dermatologische Verwendung von Probiotischen Lactobacillus paracasei. Eur. Patent EP2149368B1 (2018)."},{"key":"53016_CR28","doi-asserted-by":"publisher","unstructured":"Boxberger, M., Cenizo, V., Cassir, N. & La Scola, B. Challenges in exploring and manipulating the human skin microbiome. Microbiome. 9,125; https:\/\/doi.org\/10.1186\/s40168-021-01062-5 (2021).","DOI":"10.1186\/s40168-021-01062-5"},{"key":"53016_CR29","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.614446","volume":"10","author":"SH Vijaya Chandra","year":"2021","unstructured":"Vijaya Chandra, S. H., Srinivas, R., Dawson, T. L. Jr. & Common, J. E. Cutaneous malassezia: commensal, pathogen, or protector?. Front. Cell. Infect. Microbiol. 10, 614446 (2021).","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"53016_CR30","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a019802","volume":"4","author":"TC White","year":"2014","unstructured":"White, T. C. et al. Fungi on the skin: Dermatophytes and Malassezia. Cold Spring Harb. Perspect. Med. 4, a019802 (2014).","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"53016_CR31","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1111\/exd.12552","volume":"23","author":"M Kistowska","year":"2014","unstructured":"Kistowska, M. et al. Malassezia yeasts activate the NLRP3 inflammasome in antigen-presenting cells via Syk-kinase signaling. Exp. Dermatol. 23, 884\u2013889 (2014).","journal-title":"Exp. Dermatol."},{"key":"53016_CR32","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1034\/j.1600-0846.2002.20337.x","volume":"8","author":"MA Perkins","year":"2002","unstructured":"Perkins, M. A., Cardin, C. W., Osterhues, M. A. & Robinson, M. K. A non-invasive tape absorption method for recovery of inflammatory mediators to differentiate normal from compromised scalp conditions. Skin Res. Technol. 8, 187\u2013193 (2002).","journal-title":"Skin Res. Technol."},{"key":"53016_CR33","doi-asserted-by":"crossref","unstructured":"Vlachos, C., Schulte, B. M., Magiatis, P., Adema, G. J. & Gaitanis, G. Malassezia-derived indoles activate the aryl hydrocarbon receptor and inhibit Toll-like receptor-induced maturation in monocyte-derived dendritic cells. Br. J. Dermatol. 167, 496\u2013505. 7 (2012).","DOI":"10.1111\/j.1365-2133.2012.11014.x"},{"key":"53016_CR34","doi-asserted-by":"publisher","unstructured":"Hoggard, M., Vesty, A., Wong, G., Montgomery, J. M., Fourieet C., al. Characterizing the human mycobiota: A comparison of small subunit rRNA, ITS1, ITS2, and large subunit rRNA genomic targets. Front. Microbiol. 9, 2208; https:\/\/doi.org\/10.3389\/fmicb.2018.02208 (2018).","DOI":"10.3389\/fmicb.2018.02208"},{"key":"53016_CR35","doi-asserted-by":"publisher","unstructured":"Lucking, R., Aime, M. C., Robbertse, B., Miller, A. N., Ariyawansa, H. A., et al. Unambiguous identification of fungi: Where do we stand and how accurate and precise is fungal DNA barcoding? IMA Fungus 11, 14; https:\/\/doi.org\/10.1186\/s43008-020-00033-z (2020).","DOI":"10.1186\/s43008-020-00033-z"},{"key":"53016_CR36","doi-asserted-by":"publisher","unstructured":"Wikramanayake, T. C., Borda, L. J., Miteva, M. & Paus, R. Seborrheic dermatitis-Looking beyond Malassezia. Exp. Dermatol 28, 991\u20131001; https:\/\/doi.org\/10.1111\/exd.14006 (2019).","DOI":"10.1111\/exd.14006"},{"key":"53016_CR37","doi-asserted-by":"publisher","first-page":"24877","DOI":"10.1038\/srep24877","volume":"6","author":"Z Xu","year":"2016","unstructured":"Xu, Z. et al. Dandruff is associated with the conjoined interactions between host and microorganisms. Sci. Rep. 6, 24877. https:\/\/doi.org\/10.1038\/srep24877 (2016).","journal-title":"Sci. Rep."},{"key":"53016_CR38","doi-asserted-by":"publisher","unstructured":"Tamer, F., Yuksel, M. E., Sarifakioglu, E. & Karabag, Y. Staphylococcus aureus is the most common bacterial agent of the skin flora of patients with seborrheic dermatitis. Dermatol. Pract. Concept. 8, 80\u201384; https:\/\/doi.org\/10.5826\/dpc.0802a04 (2018).","DOI":"10.5826\/dpc.0802a04"},{"key":"53016_CR39","doi-asserted-by":"publisher","first-page":"S10","DOI":"10.1093\/mmy\/myx134","volume":"56","author":"B Theelen","year":"2018","unstructured":"Theelen, B. et al. Malassezia ecology, pathophysiology, and treatment. Med. Mycol. 56, S10\u2013S25. https:\/\/doi.org\/10.1093\/mmy\/myx134 (2018).","journal-title":"Med. Mycol."},{"key":"53016_CR40","doi-asserted-by":"publisher","first-page":"301","DOI":"10.3390\/microorganisms7090301","volume":"7","author":"EG Di Domenico","year":"2019","unstructured":"Di Domenico, E. G. et al. Staphylococcus aureus and the cutaneous microbiota biofilms in the pathogenesis of atopic dermatitis. Microorganisms. 7, 301. https:\/\/doi.org\/10.3390\/microorganisms7090301 (2019).","journal-title":"Microorganisms."},{"key":"53016_CR41","doi-asserted-by":"publisher","unstructured":"Parolin, C., Croatti, V., Laghi, L., Giordani, B., Tondi, M. R. et al. Lactobacillus Biofilms Influence Anti-Candida Activity. Front. Microbiol. 12, 750368; https:\/\/doi.org\/10.3389\/fmicb.2021.750368 (2021).","DOI":"10.3389\/fmicb.2021.750368"},{"key":"53016_CR42","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s40168-019-0667-9","volume":"7","author":"C van der Veer","year":"2019","unstructured":"van der Veer, C. et al. Comparative genomics of human Lactobacillus crispatus isolates reveals genes for glycosylation and glycogen degradation: implications for in vivo dominance of the vaginal microbiota. Microbiome. 7, 49. https:\/\/doi.org\/10.1186\/s40168-019-0667-9 (2019).","journal-title":"Microbiome."},{"key":"53016_CR43","doi-asserted-by":"publisher","first-page":"94","DOI":"10.3390\/biom11010094","volume":"11","author":"A Stivala","year":"2021","unstructured":"Stivala, A., Carota, G., Fuochi, V. & Furneri, P. M. Lactobacillus rhamnosus AD3 as a promising alternative for probiotic products. Biomolecules 11, 94. https:\/\/doi.org\/10.3390\/biom11010094 (2021).","journal-title":"Biomolecules"},{"key":"53016_CR44","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/s41522-020-00159-3","volume":"6","author":"A Heumann","year":"2020","unstructured":"Heumann, A. et al. Intestinal release of biofilm-like microcolonies encased in calcium-pectinate beads increases probiotic properties of Lacticaseibacillus paracasei. NPJ. Biofilms Microbiomes. 6, 44. https:\/\/doi.org\/10.1038\/s41522-020-00159-3 (2020).","journal-title":"NPJ. Biofilms Microbiomes."},{"key":"53016_CR45","doi-asserted-by":"publisher","unstructured":"Archambault, L., Koshy-Chenthittayil, S., Thompson, A., Dongari-Bagtzoglou, A., Laubenbacher, R. et al. Corrected and Republished from: \"Understanding Lactobacillus paracasei and Streptococcus oralis Biofilm Interactions through Agent-Based Modeling\". mSphere. 8, e0065622; https:\/\/doi.org\/10.1128\/msphere.00656-22 (2023).","DOI":"10.1128\/msphere.00656-22"},{"key":"53016_CR46","doi-asserted-by":"publisher","unstructured":"Li, H., Goh, B. N., Teh, W. K., Jiang, Z., Goh, J. P. Z., et al. Skin commensal Malassezia globosa secreted protease attenuates Staphylococcus aureus biofilm formation. J. Invest. Dermatol. 138, 1137\u20131145; https:\/\/doi.org\/10.1016\/j.jid.2017.11.034 (2018).","DOI":"10.1016\/j.jid.2017.11.034"},{"key":"53016_CR47","doi-asserted-by":"publisher","unstructured":"Lyou, E.S., Kim, M. S., Kim, S.B., Park, M., Kim K-D, et al. Single-cell phenotypes revealed as a key biomarker in bacterial-fungal interactions: a case study of Staphylococcus and Malassezia. Microbiol. Spectr. 11, e0043723; https:\/\/doi.org\/10.1128\/spectrum.00437-23 (2023).","DOI":"10.1128\/spectrum.00437-23"},{"key":"53016_CR48","doi-asserted-by":"publisher","unstructured":"Zangl, I., Pap, I. J., Asp\u00f6ck, C., Sch\u00fcller, C. The role of Lactobacillus species in the control of Candida via biotrophic interactions. Microb. Cell. 7, 1\u201314; https:\/\/doi.org\/10.15698\/mic2020.01.702 (2019).","DOI":"10.15698\/mic2020.01.702"},{"key":"53016_CR49","doi-asserted-by":"publisher","unstructured":"Li, J., Feng, Y., Liu, C., Yang, Z., de Hoog, S. et al. Presence of Malassezia Hyphae Is Correlated with Pathogenesis of Seborrheic Dermatitis. Microbiol. Spectr. 10, e0116921; https:\/\/doi.org\/10.1128\/spectrum.01169-21 (2022).","DOI":"10.1128\/spectrum.01169-21"},{"key":"53016_CR50","doi-asserted-by":"publisher","first-page":"235","DOI":"10.2165\/00128071-200708040-00005","volume":"8","author":"A Comert","year":"2007","unstructured":"Comert, A., Bekiroglu, N., Gurbuz, O. & Ergun, T. Efficacy of oral fluconazole in the treatment of seborrheic dermatitis. Am. J. Clin. Dermatol. 8, 235\u2013238 (2007).","journal-title":"Am. J. Clin. Dermatol."},{"key":"53016_CR51","doi-asserted-by":"publisher","unstructured":"Cavallo, I., Sivori, F., Truglio, M., De Maio, F., Lucantoni, F. et al. Skin dysbiosis and Cutibacterium acnes biofilm in inflammatory acne lesions of adolescents. Sci. Rep. 12, 21104; https:\/\/doi.org\/10.1038\/s41598-022-25436-3 (2022).","DOI":"10.1038\/s41598-022-25436-3"},{"key":"53016_CR52","doi-asserted-by":"publisher","unstructured":"Bolyen, E., Rideout, J. R., Dillon, M. R., Bokulich, N. A., Abnet, C. C. et al. Reproducible, interactive, scalable, and extensible microbiome data science using QIIME 2. Nat. Biotechnol. 37, 852\u2013857; https:\/\/doi.org\/10.1038\/s41587-019-0209-9 (2019).","DOI":"10.1038\/s41587-019-0209-9"},{"key":"53016_CR53","doi-asserted-by":"publisher","unstructured":"Quast, C., Pruesse, E., Yilmaz, P., Gerken, J., Schweer, T. et al. The SILVA ribosomal RNA gene database project: improved data processing and web-based tools. Nucleic Acids Res. 41, D590\u2013596; https:\/\/doi.org\/10.1093\/nar\/gks1219 (2013).","DOI":"10.1093\/nar\/gks1219"},{"key":"53016_CR54","doi-asserted-by":"publisher","unstructured":"Nilsson, R. H., Larsson, K. H., Taylor, A. F. S., Bengtsson-Palme, J., Jeppesen, T. S. et al. The UNITE database for molecular identification of fungi: handling dark taxa and parallel taxonomic classifications. Nucleic Acids Res. https:\/\/doi.org\/10.1093\/nar\/gky1022 (2018).","DOI":"10.1093\/nar\/gky1022"},{"key":"53016_CR55","doi-asserted-by":"publisher","unstructured":"Mallick, H., Rahnavard, A., McIver, L. J., Ma, S., Zhang, Y. et al. \u201cMultivariable Association in Population-scale Meta-omics Studies.\u201d PLOS Computat. Biol. 17, e1009442; https:\/\/doi.org\/10.1371\/journal.pcbi.1009442 (2021).","DOI":"10.1371\/journal.pcbi.1009442"},{"key":"53016_CR56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v048.i04","volume":"48","author":"S Epskamp","year":"2012","unstructured":"Epskamp, S., Cramer, A. O. J., Waldorp, L. J., Schmittmann, V. D. & Borsboom, D. qgraph: network visualizations of relationships in psychometric data. J. Stat. Softw. 48, 1\u201318 (2012).","journal-title":"J. Stat. Softw."},{"key":"53016_CR57","doi-asserted-by":"publisher","unstructured":"Di Domenico, E. G., Cavallo, I., Sivori, F., Marchesi, F., Prignano, G. et al. Biofilm Production by Carbapenem-Resistant Klebsiella pneumoniae Significantly Increases the Risk of Death in Oncological Patients. Front. Cell Infect. Microbiol. 10, 561741; https:\/\/doi.org\/10.3389\/fcimb.2020.561741 (2020).","DOI":"10.3389\/fcimb.2020.561741"},{"key":"53016_CR58","doi-asserted-by":"publisher","unstructured":"Sivori, F., Cavallo, I., Kovacs, D., Guembe, M., Sperduti, I. et al. Role of Extracellular DNA in Dalbavancin Activity against Methicillin-Resistant Staphylococcus aureus (MRSA) Biofilms in Patients with Skin and Soft Tissue Infections. Microbiol. Spectr. 10, e0035122; https:\/\/doi.org\/10.1128\/spectrum.00351-22 (2022).","DOI":"10.1128\/spectrum.00351-22"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-53016-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-53016-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-53016-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T17:11:21Z","timestamp":1706807481000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-53016-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,1]]},"references-count":58,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["53016"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-53016-0","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,1]]},"assertion":[{"value":"19 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"2722"}}