{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:46:06Z","timestamp":1790703966241,"version":"4.1.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T00:00:00Z","timestamp":1706918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T00:00:00Z","timestamp":1706918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"59MDW Office of the Chief Scientist Office","award":["AC20COV10"],"award-info":[{"award-number":["AC20COV10"]}]},{"name":"59MDW Office of the Chief Scientist Office","award":["AC20COV10"],"award-info":[{"award-number":["AC20COV10"]}]},{"name":"59MDW Office of the Chief Scientist Office","award":["AC20COV10"],"award-info":[{"award-number":["AC20COV10"]}]},{"name":"59MDW Office of the Chief Scientist Office","award":["AC20COV10"],"award-info":[{"award-number":["AC20COV10"]}]},{"DOI":"10.13039\/100008634","name":"University of Texas at San Antonio","doi-asserted-by":"publisher","award":["Jacobson Endowment"],"award-info":[{"award-number":["Jacobson Endowment"]}],"id":[{"id":"10.13039\/100008634","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008634","name":"University of Texas at San Antonio","doi-asserted-by":"publisher","award":["Jacobson Endowment"],"award-info":[{"award-number":["Jacobson Endowment"]}],"id":[{"id":"10.13039\/100008634","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008634","name":"University of Texas at San Antonio","doi-asserted-by":"publisher","award":["Jacobson Endowment"],"award-info":[{"award-number":["Jacobson Endowment"]}],"id":[{"id":"10.13039\/100008634","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000084","name":"Directorate for Engineering","doi-asserted-by":"publisher","award":["1847103"],"award-info":[{"award-number":["1847103"]}],"id":[{"id":"10.13039\/100000084","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Corticosteroid-eluting endotracheal tubes (ETTs) were developed and employed in a swine laryngotracheal injury model to maintain airway patency and provide localized drug delivery to inhibit fibrotic scarring. Polycaprolactone (PCL) fibers with or without dexamethasone were electrospun onto the ETT surface PCL-only coated ETTs and placed in native airways of 18 Yorkshire swine. Regular and dexamethasone-PCL coated ETTs were placed in airways of another 18 swine injured by inner laryngeal mucosal abrasion. All groups were evaluated after 3, 7 and 14\u00a0days (n\u2009=\u20093\/treatment\/time). Larynges were bisected and localized stiffness determined by normal indentation, then sequentially matched with histological assessment. In the native airway, tissue stiffness with PCL-only ETT placement increased significantly from 3 to 7\u00a0days (<jats:italic>p\u2009<\/jats:italic>=\u20090.0016) and 3 to 14\u00a0days (<jats:italic>p\u2009<\/jats:italic>&lt;\u20090.0001) while dexamethasone-PCL ETT placement resulted in stiffness decreasing from 7 to 14\u00a0days (<jats:italic>p\u2009<\/jats:italic>=\u20090.031). In the injured airway, localized stiffness at 14\u00a0days was significantly greater after regular ETT placement (23.1\u2009\u00b1\u20090.725\u00a0N\/m) versus dexamethasone-PCL ETTs (17.10\u2009\u00b1\u20090.930\u00a0N\/m, <jats:italic>p\u2009<\/jats:italic>&lt;\u20090.0001). Dexamethasone-loaded ETTs were found to reduce laryngotracheal tissue stiffening after simulated intubation injury compared to regular ETTs, supported by a trend of reduced collagen in the basement membrane in injured swine over time. Findings suggest localized corticosteroid delivery allows for tissue stiffness control and potential use as an approach for prevention and treatment of scarring caused by intubation injury.<\/jats:p>","DOI":"10.1038\/s41598-024-53328-1","type":"journal-article","created":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T04:59:01Z","timestamp":1706936341000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Endotracheal tubes with dexamethasone eluting electrospun coating improve tissue mechanical function after upper airway injury"],"prefix":"10.1038","volume":"14","author":[{"given":"Gabriela","family":"Gonzales","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronit","family":"Malka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Marinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine M.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solaleh","family":"Miar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy","family":"Cook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory R.","family":"Dion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teja","family":"Guda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,3]]},"reference":[{"key":"53328_CR1","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1016\/S0140-6736(10)60446-1","volume":"376","author":"NK Adhikari","year":"2010","unstructured":"Adhikari, N. K., Fowler, R. A., Bhagwanjee, S. & Rubenfeld, G. D. Critical care and the global burden of critical illness in adults. Lancet 376, 1339\u20131346. https:\/\/doi.org\/10.1016\/S0140-6736(10)60446-1 (2010).","journal-title":"Lancet"},{"key":"53328_CR2","doi-asserted-by":"publisher","first-page":"2010","DOI":"10.1097\/CCM.0000000000003368","volume":"46","author":"MB Brodsky","year":"2018","unstructured":"Brodsky, M. B. et al. Laryngeal injury and upper airway symptoms after oral endotracheal intubation with mechanical ventilation during critical care: A systematic review. Crit. Care Med. 46, 2010\u20132017. https:\/\/doi.org\/10.1097\/CCM.0000000000003368 (2018).","journal-title":"Crit. Care Med."},{"key":"53328_CR3","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1097\/ccm.0000000000004015","volume":"47","author":"JR Shinn","year":"2019","unstructured":"Shinn, J. R. et al. Incidence and outcomes of acute laryngeal injury after prolonged mechanical ventilation. Crit. Care Med. 47, 1699\u20131706. https:\/\/doi.org\/10.1097\/ccm.0000000000004015 (2019).","journal-title":"Crit. Care Med."},{"key":"53328_CR4","doi-asserted-by":"publisher","first-page":"355","DOI":"10.25122\/jml-2020-0148","volume":"14","author":"AAA Saeg","year":"2021","unstructured":"Saeg, A. A. A. & Alnori, H. Laryngeal injury and dysphonia after endotracheal intubation. J. Med. Life 14, 355\u2013360. https:\/\/doi.org\/10.25122\/jml-2020-0148 (2021).","journal-title":"J. Med. Life"},{"key":"53328_CR5","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1177\/0003489418790348","volume":"127","author":"B Benjamin","year":"2018","unstructured":"Benjamin, B. Prolonged intubation injuries of the larynx: Endoscopic diagnosis, classification, aqnd treatment. Ann. Otol. Rhinol. Laryngol. 127, 492\u2013507. https:\/\/doi.org\/10.1177\/0003489418790348 (2018).","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"53328_CR6","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1007\/s00134-010-1847-z","volume":"36","author":"JM Tadie","year":"2010","unstructured":"Tadie, J. M. et al. Post-intubation laryngeal injuries and extubation failure: A fiberoptic endoscopic study. Intensive Care Med. 36, 991\u2013998. https:\/\/doi.org\/10.1007\/s00134-010-1847-z (2010).","journal-title":"Intensive Care Med."},{"key":"53328_CR7","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.bjae.2021.02.005","volume":"21","author":"S Wallace","year":"2021","unstructured":"Wallace, S. & McGrath, B. A. Laryngeal complications after tracheal intubation and tracheostomy. BJA Educ. 21, 250\u2013257. https:\/\/doi.org\/10.1016\/j.bjae.2021.02.005 (2021).","journal-title":"BJA Educ."},{"key":"53328_CR8","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.4187\/respcare.02884","volume":"59","author":"PC Pacheco-Lopez","year":"2014","unstructured":"Pacheco-Lopez, P. C., Berkow, L. C., Hillel, A. T. & Akst, L. M. Complications of airway management. Respir. Care 59, 1006\u20131019. https:\/\/doi.org\/10.4187\/respcare.02884 (2014).","journal-title":"Respir. Care"},{"key":"53328_CR9","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1002\/lary.24178","volume":"124","author":"B Sadoughi","year":"2014","unstructured":"Sadoughi, B., Fried, M. P., Sulica, L. & Blitzer, A. Hoarseness evaluation: A transatlantic survey of laryngeal experts. Laryngoscope 124, 221\u2013226. https:\/\/doi.org\/10.1002\/lary.24178 (2014).","journal-title":"Laryngoscope"},{"key":"53328_CR10","doi-asserted-by":"publisher","first-page":"1948","DOI":"10.1002\/hed.27079","volume":"44","author":"DJ Carpenter","year":"2022","unstructured":"Carpenter, D. J., Hamdi, O. A., Finberg, A. M. & Daniero, J. J. Laryngotracheal stenosis: Mechanistic review. Head Neck 44, 1948\u20131960. https:\/\/doi.org\/10.1002\/hed.27079 (2022).","journal-title":"Head Neck"},{"key":"53328_CR11","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1016\/S1808-8694(15)30155-5","volume":"74","author":"AM Campagnolo","year":"2008","unstructured":"Campagnolo, A. M., Tsuji, D. H., Sennes, L. U. & Imamura, R. Steroid injection in chronic inflammatory vocal fold disorders, literature review. Braz. J. Otorhinolaryngol. 74, 926\u2013932. https:\/\/doi.org\/10.1016\/S1808-8694(15)30155-5 (2008).","journal-title":"Braz. J. Otorhinolaryngol."},{"key":"53328_CR12","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1097\/MOO.0b013e32833fe112","volume":"18","author":"M Mortensen","year":"2010","unstructured":"Mortensen, M. Laryngeal steroid injection for vocal fold scar. Curr. Opin. Otolaryngol. Head Neck Surg. 18, 487\u2013491. https:\/\/doi.org\/10.1097\/MOO.0b013e32833fe112 (2010).","journal-title":"Curr. Opin. Otolaryngol. Head Neck Surg."},{"key":"53328_CR13","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1001\/jamaoto.2020.4517","volume":"147","author":"AS Lowery","year":"2021","unstructured":"Lowery, A. S. et al. Early intervention for the treatment of acute laryngeal injury after intubation. JAMA Otolaryngol. Head Neck Surg. 147, 232\u2013237. https:\/\/doi.org\/10.1001\/jamaoto.2020.4517 (2021).","journal-title":"JAMA Otolaryngol. Head Neck Surg."},{"key":"53328_CR14","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1097\/01.mlg.0000225377.33945.14","volume":"116","author":"SA Nouraei","year":"2006","unstructured":"Nouraei, S. A. et al. Early endoscopic treatment of acute inflammatory airway lesions improves the outcome of postintubation airway stenosis. Laryngoscope 116, 1417\u20131421. https:\/\/doi.org\/10.1097\/01.mlg.0000225377.33945.14 (2006).","journal-title":"Laryngoscope"},{"key":"53328_CR15","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1002\/lary.26874","volume":"128","author":"RA Franco Jr","year":"2018","unstructured":"Franco, R. A. Jr., Husain, I., Reder, L. & Paddle, P. Awake serial intralesional steroid injections without surgery as a novel targeted treatment for idiopathic subglottic stenosis. Laryngoscope 128, 610\u2013617 (2018).","journal-title":"Laryngoscope"},{"key":"53328_CR16","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1001\/jamaoto.2017.2800","volume":"144","author":"C Bertelsen","year":"2018","unstructured":"Bertelsen, C., Shoffel-Havakuk, H., O\u2019Dell, K., Johns, M. M. 3rd. & Reder, L. S. Serial in-office intralesional steroid injections in airway stenosis. JAMA Otolaryngol. Head Neck. Surg. 144, 203\u2013210. https:\/\/doi.org\/10.1001\/jamaoto.2017.2800 (2018).","journal-title":"JAMA Otolaryngol. Head Neck. Surg."},{"key":"53328_CR17","unstructured":"Dion, G. et al. Laryngotracheal Stenosis: Drug Delivery Approaches and Strategies. (2022)."},{"key":"53328_CR18","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.jconrel.2018.01.005","volume":"272","author":"A Abu Ammar","year":"2018","unstructured":"Abu Ammar, A. et al. Local delivery of mometasone furoate from an eluting endotracheal tube. J. Control Release 272, 54\u201361. https:\/\/doi.org\/10.1016\/j.jconrel.2018.01.005 (2018).","journal-title":"J. Control Release"},{"key":"53328_CR19","doi-asserted-by":"publisher","first-page":"4131","DOI":"10.1021\/acsabm.0c01526","volume":"4","author":"F Jahshan","year":"2021","unstructured":"Jahshan, F. et al. Local delivery of mometasone furoate from an eluting endotracheal tube reduces airway morbidity following long-term animal intubation. ACS Appl. Bio Mater. 4, 4131\u20134139. https:\/\/doi.org\/10.1021\/acsabm.0c01526 (2021).","journal-title":"ACS Appl. Bio Mater."},{"key":"53328_CR20","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.21873\/invivo.12819","volume":"36","author":"H Jung","year":"2022","unstructured":"Jung, H., Lee, J. S., Lee, J. J. & Park, H. S. Anti-inflammatory and Anti-bacterial effects of Allicin-coated tracheal tube on trachea mucosa. In Vivo 36, 1195. https:\/\/doi.org\/10.21873\/invivo.12819 (2022).","journal-title":"In Vivo"},{"key":"53328_CR21","doi-asserted-by":"publisher","first-page":"20188","DOI":"10.1021\/am505566m","volume":"6","author":"J Mokkaphan","year":"2014","unstructured":"Mokkaphan, J., Banlunara, W., Palaga, T., Sombuntham, P. & Wanichwecharungruang, S. Silicone surface with drug nanodepots for medical devices. ACS Appl. Mater. Interf. 6, 20188\u201320196. https:\/\/doi.org\/10.1021\/am505566m (2014).","journal-title":"ACS Appl. Mater. Interf."},{"key":"53328_CR22","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1002\/jbm.b.34456","volume":"108","author":"HS Lee","year":"2020","unstructured":"Lee, H. S. et al. Fabrication and biological activity of polycaprolactone\/phlorotannin endotracheal tube to prevent tracheal stenosis: An in vitro and in vivo study. J. Biomed. Mater. Res. Part B Appl. Biomater. 108, 1046\u20131056. https:\/\/doi.org\/10.1002\/jbm.b.34456 (2020).","journal-title":"J. Biomed. Mater. Res. Part B Appl. Biomater."},{"key":"53328_CR23","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1007\/s12195-023-00769-9","volume":"16","author":"MR Aronson","year":"2023","unstructured":"Aronson, M. R. et al. Amelioration of subglottic stenosis by antimicrobial peptide eluting endotracheal tubes. Cell. Mol. Bioeng. 16, 369\u2013381. https:\/\/doi.org\/10.1007\/s12195-023-00769-9 (2023).","journal-title":"Cell. Mol. Bioeng."},{"key":"53328_CR24","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1002\/lary.27999","volume":"130","author":"GR Dion","year":"2020","unstructured":"Dion, G. R. et al. Quantifying vocal fold wound-healing biomechanical property changes. Laryngoscope 130, 454\u2013459. https:\/\/doi.org\/10.1002\/lary.27999 (2020).","journal-title":"Laryngoscope"},{"key":"53328_CR25","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1159\/000263771","volume":"26","author":"M Hirano","year":"1974","unstructured":"Hirano, M. Morphological structure of the vocal cord as a vibrator and its variations. Folia Phoniatr. 26, 89\u201394. https:\/\/doi.org\/10.1159\/000263771 (1974).","journal-title":"Folia Phoniatr."},{"key":"53328_CR26","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1177\/019459989611500521","volume":"115","author":"MS Benninger","year":"1996","unstructured":"Benninger, M. S. et al. Vocal fold scarring: Current concepts and management. Otolaryngol. Head Neck Surg. 115, 474\u2013482. https:\/\/doi.org\/10.1177\/019459989611500521 (1996).","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"53328_CR27","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1097\/MOO.0b013e32833fecd1","volume":"18","author":"J Allen","year":"2010","unstructured":"Allen, J. Cause of vocal fold scar. Curr. Opin. Otolaryngol. Head Neck. Surg. 18, 475\u2013480. https:\/\/doi.org\/10.1097\/MOO.0b013e32833fecd1 (2010).","journal-title":"Curr. Opin. Otolaryngol. Head Neck. Surg."},{"key":"53328_CR28","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.jvoice.2004.12.005","volume":"20","author":"JK Hansen","year":"2006","unstructured":"Hansen, J. K. & Thibeault, S. L. Current understanding and review of the literature: vocal fold scarring. J. Voice 20, 110\u2013120. https:\/\/doi.org\/10.1016\/j.jvoice.2004.12.005 (2006).","journal-title":"J. Voice"},{"key":"53328_CR29","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1002\/lary.26123","volume":"127","author":"GR Dion","year":"2017","unstructured":"Dion, G. R. et al. Development of an in vivo model of laryngeal burn injury. The Laryngoscope 127, 186\u2013190. https:\/\/doi.org\/10.1002\/lary.26123 (2017).","journal-title":"The Laryngoscope"},{"key":"53328_CR30","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1002\/lary.29873","volume":"132","author":"OK Kadosh","year":"2022","unstructured":"Kadosh, O. K. et al. Establishing an endoscopic chronic subglottic stenosis rabbit model. The Laryngoscope 132, 1909\u20131915. https:\/\/doi.org\/10.1002\/lary.29873 (2022).","journal-title":"The Laryngoscope"},{"key":"53328_CR31","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.jvoice.2003.06.001","volume":"18","author":"B Rousseau","year":"2004","unstructured":"Rousseau, B. et al. Characterization of chronic vocal fold scarring in a rabbit model. J. Voice 18, 116\u2013124. https:\/\/doi.org\/10.1016\/j.jvoice.2003.06.001 (2004).","journal-title":"J. Voice"},{"key":"53328_CR32","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/s0892-1997(02)00078-4","volume":"16","author":"SL Thibeault","year":"2002","unstructured":"Thibeault, S. L., Gray, S. D., Bless, D. M., Chan, R. W. & Ford, C. N. Histologic and rheologic characterization of vocal fold scarring. J. Voice 16, 96\u2013104. https:\/\/doi.org\/10.1016\/s0892-1997(02)00078-4 (2002).","journal-title":"J. Voice"},{"key":"53328_CR33","doi-asserted-by":"publisher","first-page":"2234","DOI":"10.1002\/lary.22175","volume":"121","author":"GH Zhu","year":"2011","unstructured":"Zhu, G. H. et al. A novel bioabsorbable drug-eluting tracheal stent. Laryngoscope 121, 2234\u20132239. https:\/\/doi.org\/10.1002\/lary.22175 (2011).","journal-title":"Laryngoscope"},{"key":"53328_CR34","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1007\/s00134-008-1099-3","volume":"34","author":"L Berra","year":"2008","unstructured":"Berra, L. et al. Antimicrobial-coated endotracheal tubes: an experimental study. Intensive Care Med. 34, 1020\u20131029. https:\/\/doi.org\/10.1007\/s00134-008-1099-3 (2008).","journal-title":"Intensive Care Med."},{"key":"53328_CR35","doi-asserted-by":"publisher","first-page":"871","DOI":"10.21037\/atm-21-1930","volume":"9","author":"J Lu","year":"2021","unstructured":"Lu, J. et al. Lidocaine-eluting endotracheal tube effectively attenuates intubation related airway response. Ann. Transl. Med. 9, 871. https:\/\/doi.org\/10.21037\/atm-21-1930 (2021).","journal-title":"Ann. Transl. Med."},{"key":"53328_CR36","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1002\/lary.29769","volume":"132","author":"MR Aronson","year":"2022","unstructured":"Aronson, M. R. et al. Drug-eluting endotracheal tubes for preventing bacterial inflammation in subglottic stenosis. Laryngoscope 132, 1356\u20131363. https:\/\/doi.org\/10.1002\/lary.29769 (2022).","journal-title":"Laryngoscope"},{"key":"53328_CR37","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1001\/jama.300.7.805","volume":"300","author":"MH Kollef","year":"2008","unstructured":"Kollef, M. H. et al. Silver-coated endotracheal tubes and incidence of ventilator-associated pneumonia: The NASCENT randomized trial. JAMA 300, 805\u2013813. https:\/\/doi.org\/10.1001\/jama.300.7.805 (2008).","journal-title":"JAMA"},{"key":"53328_CR38","doi-asserted-by":"publisher","first-page":"10288","DOI":"10.1021\/acsomega.9b04178","volume":"5","author":"B Ozcelik","year":"2020","unstructured":"Ozcelik, B. et al. Evaluation of the novel antimicrobial BCP3 in a coating for endotracheal tubes. ACS Omega 5, 10288\u201310296. https:\/\/doi.org\/10.1021\/acsomega.9b04178 (2020).","journal-title":"ACS Omega"},{"key":"53328_CR39","doi-asserted-by":"publisher","first-page":"4846","DOI":"10.1039\/C9NR10341D","volume":"12","author":"SJ Lee","year":"2020","unstructured":"Lee, S. J. et al. Dexamethasone loaded bilayered 3D tubular scaffold reduces restenosis at the anastomotic site of tracheal replacement: in vitro and in vivo assessments. Nanoscale 12, 4846\u20134858. https:\/\/doi.org\/10.1039\/C9NR10341D (2020).","journal-title":"Nanoscale"},{"key":"53328_CR40","doi-asserted-by":"publisher","first-page":"E26","DOI":"10.1002\/lary.27341","volume":"129","author":"GR Dion","year":"2019","unstructured":"Dion, G. R., Lavoie, J. F., Coelho, P., Amin, M. R. & Branski, R. C. Automated indentation mapping of vocal fold structure and cover properties across species. Laryngoscope 129, E26\u2013E31. https:\/\/doi.org\/10.1002\/lary.27341 (2019).","journal-title":"Laryngoscope"},{"key":"53328_CR41","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1002\/lio2.853","volume":"7","author":"S Miar","year":"2022","unstructured":"Miar, S. et al. Augmentation and vocal fold biomechanics in a recurrent laryngeal nerve injury model. Laryngoscope Investig. Otolaryngol. 7, 1057\u20131064. https:\/\/doi.org\/10.1002\/lio2.853 (2022).","journal-title":"Laryngoscope Investig. Otolaryngol."},{"key":"53328_CR42","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1002\/lio2.1093","volume":"8","author":"R Malka","year":"2023","unstructured":"Malka, R. et al. Effect of continuous local dexamethasone on tissue biomechanics and histology after inhalational burn in a preclinical model. Laryngoscope Investig. Otolaryngol. 8, 939\u2013945. https:\/\/doi.org\/10.1002\/lio2.1093 (2023).","journal-title":"Laryngoscope Investig. Otolaryngol."},{"key":"53328_CR43","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1093\/bioinformatics\/btaa847","volume":"37","author":"G Landini","year":"2021","unstructured":"Landini, G., Martinelli, G. & Piccinini, F. Colour deconvolution: Stain unmixing in histological imaging. Bioinformatics 37, 1485\u20131487. https:\/\/doi.org\/10.1093\/bioinformatics\/btaa847 (2021).","journal-title":"Bioinformatics"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-53328-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-53328-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-53328-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T08:04:07Z","timestamp":1707206647000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-53328-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,3]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["53328"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-53328-1","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,3]]},"assertion":[{"value":"30 March 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"2821"}}