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Yet the current clinical guideline remains a one-size-fits-all \u201cmaximum diameter criterion\u201d whereby AAA exceeding a threshold diameter is thought to make the risk of rupture high enough to warrant intervention. However, between 7 and 23.4% of smaller-sized AAA have been reported to rupture with diameters below the threshold. In this study, we train and assess machine learning models using clinical, biomechanical, and morphological indices from 381 patients to develop an aneurysm prognosis classifier to predict one of three outcomes for a given AAA patient: their AAA will remain stable, their AAA will require repair based as currently indicated from the maximum diameter criterion, or their AAA will rupture. This study represents the largest cohort of AAA patients that utilizes the first available medical image and clinical data to classify patient outcomes. The APC model therefore represents a potential clinical tool to striate specific patient outcomes using machine learning models and patient-specific image-based (biomechanical and morphological) and clinical data as input. Such a tool could greatly assist clinicians in their management decisions for patients with AAA.<\/jats:p>","DOI":"10.1038\/s41598-024-53459-5","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T14:02:17Z","timestamp":1707487337000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["An artificial intelligence based abdominal aortic aneurysm prognosis classifier to predict patient outcomes"],"prefix":"10.1038","volume":"14","author":[{"given":"Timothy K.","family":"Chung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pete H.","family":"Gueldner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Okechukwu U.","family":"Aloziem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan L.","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Vorp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,9]]},"reference":[{"key":"53459_CR1","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1016\/j.jbiomech.2006.09.003.BIOMECHANICS","volume":"40","author":"DA Vorp","year":"2009","unstructured":"Vorp, D. 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